Objectives: To investigate whether a multi-item performance outcome measure, the physical performance test (PPT), can be calibrated to a common scale with patient-reported outcome measures, using the Patient-Reported Outcomes Measurement Information System (PROMIS) physical function (PF) metric. Study Design and Setting: We analyzed baseline data (N = 1,113) from the CONVINCE study, an internation

Between 15 and 27kyrb2k (thousands of years before 2000CE) during the last glacial, Greenland experienced a prolonged cold stadial phase, interrupted by two short-lived warm interstadials. Greenland ice-core calcium data show two periods, preceding the interstadials, of anomalously high atmospheric dust loading, the origin of which is not well understood. At approximately the same time as the Gree

Background: Contrary to the presumption that type 1 diabetes leads to an absolute insulin deficiency, many individuals with type 1 diabetes have circulating C-peptide years after the diagnosis. We studied factors affecting random serum C-peptide concentration in individuals with type 1 diabetes and the association with diabetic complications. Methods: Our longitudinal analysis included individuals

Resistivity imaging in combination with borehole information is a powerful tool for site investigation. We show that the combination of 1D laterally constrained inversion (1D-LCI) with the use of a priori information from borehole data and 2D smooth inversion adds significant value to the interpretation of continuous vertical electrical sounding (CVES) data. The 1D-LCI offers an analysis of the re

Seamless integration between biological systems and electrical components is essential for enabling a twinned biochemical-electrical recording and therapy approach to understand and combat neurological disorders. Employing bioelectronic systems made up of conjugated polymers, which have an innate ability to transport both electronic and ionic charges, provides the possibility of such integration.

Statin dosage in patients with acute myocardial infarction (AMI) and concomitant kidney dysfunction is a clinical dilemma. We studied discontinuation during the first year after an AMI and long-term outcome in patients receiving high versus low-moderate intensity statin treatment, in relation to kidney function. For the intention-to-treat analysis (ITT-A), we included all patients admitted to Swed

Markstabilisering blir allt vanligare för exploatering av områden med dålig bärighet.Det finns dock behov av bättre och volymstäckande kontrollmetoder förkvalitetssäkring. Kontrollmetoderna kan delas upp i två steg, där det första sker iomedelbar anslutning till inblandning av bindemedel för att kontrollera om manlyckats behandla hela den avsedda volymen, eller om det finns zoner som behöverkompleSoil stabilisation is becoming increasingly common for the development of areas withpoor bearing capacity. However, there is a need for better and volume-wide controlmethods for quality assurance. The control methods can be divided into two steps,where the first takes place in immediate connection to the mixing of binders to checkwhether the entire intended volume has been successfully treated, or

Resolving the structural dynamics of bond breaking, bond formation, and solvation is required for a deeper understanding of solution-phase chemical reactions. In this work, we investigate the photodissociation of triiodide in four solvents using femtosecond time-resolved X-ray solution scattering following 400 nm photoexcitation. Structural analysis of the scattering data resolves the solvent-depe

We present a novel design of an electrode arrangement for measurement of the resistivity of soil samples contained in a sample cylinder used in standard geotechnical site investigations in Sweden. The objective is to make it possible to measure the resistivity of the same samples that are to be used for mechanical tests, without disturbing the samples in order to get unbiased mechanical test data.

One major risk threatening embankment dam integrity is internal erosion of the core. Internal erosion progresses inside the dam but it is difficult to detect with conventional methods. Electrical Resistivity Tomography (ERT) is a potential-based method that can sense the interior of the dam, and this study aims to evaluate the capability of ERT as a complementary monitoring technique for discoveri

This article discusses the difficulties of establishing whether there exists a proven therapeutic intervention when regenerative experimental treatments are made accessible to patients under conditional approval programs (outside clinical trials). Conditional approvals are often made on the basis of less robust efficacy evidence than otherwise required for the registration of new treatments. Lower

RNA binding motif protein X‐linked (RBMX) encodes the heterogeneous nuclear ribonucleoprotein G (hnRNP G) that regulates splicing, sister chromatid cohesion and genome stability. RBMX knock down experiments in various model organisms highlight the gene’s importance for brain development. Deletion of the RGG/RG motif in hnRNP G has previously been associated with Shashi syndrome, however involvemen

Coherent tunneling processes of multiple Cooper pairs across a Josephson junction give rise to high harmonics in the current phase relation. In this work, we propose and study Josephson junctions based on semiconductor-superconductor-ferromagnetic insulator heterostructures to engineer nonsinusoidal current-phase relations. The gate-tunability of the charge carriers' density in the semiconductor,

Both construct specification equations (CSEs) and entropy can be used to provide a specific, causal, and rigorously mathematical conceptualization of item attributes in order to provide fit-for-purpose measurements of person abilities. This has been previously demonstrated for memory measurements. It can also be reasonably expected to be applicable to other kinds of measures of human abilities and

Co-production between public administrators and citizens has attracted renewed interest in recent years. Co-production is predominantly perceived as something desirable and is claimed to improve service efficiency and outcome and user satisfaction, at the same time as addressing democratic ideals. Drawing from interviews with public administrators and patients in a Swedish healthcare context, this

Therapeutic proteins can be challenging to develop due to their complexity and the requirement of an acceptable formulation to ensure patient safety and efficacy. To date, there is no universal formulation development strategy that can identify optimal formulation conditions for all types of proteins in a fast and reliable manner. In this work, high-throughput characterization, employing a toolbox