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Tillitsbaserad styrning - till demokratins försvar

Demokratin kräver en fin väv av normer och strukturer för att kunna fungera. De fria allmänna valen är bara en del av många i denna väv. En annan del är starka och modiga professioner i det offentliga kärnuppdraget. Med sitt omdöme och sin professionella etik utgör dessa grupper en trygghet för våra medborgare och för deras talan i många situationer. Det finns flera skäl till att offentlig styrnin

Att verka med och för tillit som politiker : En introduktion

Genom att öka handlingsutrymmet för medarbetarna i kärnuppdraget kan offentlig sektor bli mer effektiv och serviceinriktad. Grunden är en styrning som präglas av tillit och lyhördhet. Tillit är nödvändigt för att vårt samhälle ska stå starkt och för att statliga myndigheter, kommuner och regioner ska lyckas med sina uppdrag. Men hur bygger vi tilliten?I den här boken får du en introduktion till hu

The Influence of Perioperative Fluid Therapy on N-terminal-pro-brain Natriuretic Peptide and the Association With Heart and Lung Complications in Patients Undergoing Colorectal Surgery : Secondary Results of a Clinical Randomized Assessor-blinded Multicenter Trial

OBJECTIVE: To investigate the influence of intravenous (iv) fluid volumes on the secretion of N-terminal-pro-brain natriuretic peptide (NT-Pro-BNP) in colorectal surgical patients and its association with cardiopulmonary complications (CPC). In addition, to examine if preoperative NT-Pro-BNP can predict the risk for postoperative CPC. METHODS: Blood samples from patients enrolled in a previously p

Fast and well-reported implementation: Fast-IM and RE-AIM.

Background Implementation in healthcare is often slow and poorly reported. Results include suboptimal outcomes and ad-verse consequences for patients. However, promising tools to remedy implementation speed and reporting already exist – such as the evidence-based, fast-track implementation model (Fast-IM) and the comprehensive RE-AIM (reach, effectiveness, adoption, implementation, and maintenance

Medarbetare : En historia om organisation och lekfolksuppdrag i Svenska kyrkan

Inom Svenska kyrkan talas idag ofta om vikten av att rekrytera ideella medarbetare. I en tid då de ekonomiska resurserna minskar blir det viktigt att på nytt arbeta med människors engagemang. Vi har vant oss vid att de anställda medarbetarna är många, men hur och varför växte de stora arbetslagen fram?Detta är en bok om hur lekmannamedarbetare kom att bli en naturlig del av den församlingsverksamh

Sertoli and Germ Cells Within Atrophic Seminiferous Tubules of Men With Non-Obstructive Azoospermia

Background: Infertile men with non-obstructive azoospermia (NOA) have impaired spermatogenesis. Dilated and un-dilated atrophic seminiferous tubules are often present in the testes of these patients, with the highest likelihood of active spermatogenesis in the dilated tubules. Little is known about the un-dilated tubules, which in NOA patients constitute the majority. To advance therapeutic strate

Sialic Acid Derivatives Inhibit SiaT Transporters and Delay Bacterial Growth

Antibiotic resistance is a major worldwide concern, and new drugs with mechanistically novel modes of action are urgently needed. Here, we report the structure-based drug design, synthesis, and evaluation in vitro and in cellular systems of sialic acid derivatives able to inhibit the bacterial sialic acid symporter SiaT. We designed and synthesized 21 sialic acid derivatives and screened their aff

Aspirin and NSAID use and the risk of COVID-19

Early reports raised concern that use of non-steroidal anti-inflammatory drugs (NSAIDs) may increase risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19). Users of the COVID Symptom Study smartphone application reported use of aspirin and other NSAIDs between March 24 and May 8, 2020. Users were queried daily about symptoms, COVID-19 testing, and healthcare seeki

Ethnic, gender and other sociodemographic biases in genome-wide association studies for the most burdensome non-communicable diseases : 2005-2022

INTRODUCTION: Since 2005, disease-related human genetic diversity has been intensively characterized using genome-wide association studies (GWAS). Understanding how and by whom this work was performed may yield valuable insights into the generalizability of GWAS discoveries to global populations and how high-impact genetics research can be equitably sustained in the future.MATERIALS AND METHODS: W

Linking EORTC QLQ-C-30 and PedsQL/PEDQOL physical functioning scores in patients with osteosarcoma

Purpose: The available questionnaires for quality-of-life (QoL) assessments are age-group specific, limiting comparability and impeding longitudinal analyses. The comparability of measurements, however, is a necessary condition for gaining scientific evidence. To overcome this problem, we assessed the viability of harmonising data from paediatric and adult patient-reported outcome (PRO) measures.

A modelling study of OH, NO3 and H2SO4 in 2007- 2018 at SMEAR II, Finland : Analysis of long-term trends

Major atmospheric oxidants (OH,O3 and NO3) dominate the atmospheric oxidation capacity, while H2SO4 is considered as a main driver for new particle formation. Although numerous studies have investigated the long-term trend of ozone in Europe, the trends of OH, NO3 and H2SO4 at specific sites are to a large extent unknown. The one-dimensional model SOSAA has been applied in several studies at the S

A mobile observatory powered by sun and wind for near real time measurements of atmospheric, glacial, terrestrial, limnic and coastal oceanic conditions in remote off-grid areas

Climate change is rapidly altering the Arctic environment. Although long-term environmental observations have been made at a few locations in the Arctic, the incomplete coverage from ground stations is a main limitation to observations in these remote areas. Here we present a wind and sun powered multi-purpose mobile observatory (ARC-MO) that enables near real time measurements of air, ice, land,

Development and Characterisation of a Rat Model of Parkinson's Disease

Preclinical rodent models of Parkinson’s Disease (PD) based on alpha-synuclein (αSyn) present some of the pathological hallmarks of the human condition, such as the progressive loss of dopaminergic neurons in the substantia nigra (SN) and the development of behavioural deficits. However, numerous reports on these models highlighted the variable outcomes that might originate from them if not valida

Plaque characteristics and biomarkers predicting regression and progression of carotid atherosclerosis

The factors that influence the atherosclerotic disease process in high-risk individuals remain poorly understood. Here, we used a combination of vascular imaging, risk factor assessment, and biomarkers to identify factors associated with 3-year change in carotid disease severity in a cohort of high-risk subjects treated with preventive therapy (n = 865). The results show that changes in intima-med

Noninvasive Assessment of Left Ventricular Pressure-Volume Relations : Inter- and Intraobserver Variability and Assessment Across Heart Failure Subtypes

A novel method to derive pressure-volume (PV) loops noninvasively from cardiac magnetic resonance images has recently been developed. The aim of this study was to evaluate inter- and intraobserver variability of hemodynamic parameters obtained from noninvasive PV loops in healthy controls, subclinical diastolic dysfunction (SDD), and patients with heart failure with preserved ejection fraction, mi

Association Between EEG Patterns and Serum Neurofilament Light After Cardiac Arrest : A Post Hoc Analysis of the TTM Trial

Background and ObjectivesEEG is widely used for prediction of neurologic outcome after cardiac arrest. To better understand the relationship between EEG and neuronal injury, we explored the association between EEG and neurofilament light (NfL) as a marker of neuroaxonal injury, evaluated whether highly malignant EEG patterns are reflected by high NfL levels, and explored the association of EEG bac

Metamagnetic transition and a loss of magnetic hysteresis caused by electron trapping in monolayers of single-molecule magnet Tb2@C79N

Realization of stable spin states in surface-supported magnetic molecules is crucial for their applications in molecular spintronics, memory storage or quantum information processing. In this work, we studied the surface magnetism of dimetallo-azafullerene Tb2@C79N, showing a broad magnetic hysteresis in a bulk form. Surprisingly, monolayers of Tb2@C79N exhibited a completely different behavior, w