Suicide inhibitors of the human enzyme PARP-14
Introduction: PARP-14 is a human enzyme that use NAD+ to perform ADP-ribosylation on targets, which serves as a signalling system. The enzyme is important in for instance DNA repair and immunity, as well as regulating other PARPs in the enzyme family. Background: There are several features of PARP-14 that needs to be further studied, such as its connection to some diseases and cancers. It is of gr
