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Late neonatal lupus erythematosus onset in a child born of a mother with primary Sjogren's syndrome

Background: The neonatal lupus syndrome can be present as congenital heart block (CHB) or as neonatal lupus erythematosus (NLE), both seldom passively acquired autoimmune diseases. CHB starts around week 20 of pregnancy and is a lifelong event, whereas NLE is self limiting and usually starts at the 6th week of the child's age - the maximum recorded up to week 20. Case report: An asymptomatic mothe

Uniform Bounds on the Relative Error in the Approximation of Upper Quantiles for Sums of Arbitrary Independent Random Variables

Fix any n≥1. Let X~1,…,X~n be independent random variables. For each 1≤j≤n, X~j is transformed in a canonical manner into a random variable Xj. The Xj inherit independence from the X~j. Let sy and s∗y denote the upper 1y th −−− quantile of Sn=∑nj=1Xj and S∗n=sup1≤k≤nSk, respectively. We construct a computable quantity Q−−y based on the marginal distributions of X1,…,Xn to produce upper and lower b

What limits the pedestrian? Exploring perceptions of walking in the built environment and in the context of every-day life

Walkability is often researched from the perspective of certain physical features in the built environment. However, for this paper, the point of departure was to also treat walking as a transport mode for reaching destinations and performing every-day activities. A conceptual model addressing both perceptions of the built environment and perceived limits due to every-day activities was used as a

Xylose reductase from Pichia stipitis with altered coenzyme preference improves ethanolic xylose fermentation by recombinant Saccharomyces cerevisiae

Background: Xylose reductase (XR) and xylitol dehydrogenase (XDH) from Pichia stipitis are the two enzymes most commonly used in recombinant Saccharomyces cerevisiae strains engineered for xylose utilization. The availability of NAD+ for XDH is limited during anaerobic xylose fermentation because of the preference of XR for NADPH. This in turn results in xylitol formation and reduced ethanol yield

Genomic Diversity and Admixture Differs for Stone-Age Scandinavian Foragers and Farmers

Prehistoric population structure associated with the transition to an agricultural lifestyle in Europe remains a contentious idea. Population-genomic data from 11 Scandinavian Stone Age human remains suggest that hunter-gatherers had lower genetic diversity than that of farmers. Despite their close geographical proximity, the genetic differentiation between the two Stone Age groups was greater tha

Determining universal processes related to best outcome in emergency abdominal surgery: a multicentre, international, prospective cohort study.

Emergency abdominal surgery outcomes represent an internationally important marker of healthcare quality and capacity. In this study, a novel approach to investigating global surgical outcomes is proposed, involving collaborative methodology using 'snapshot' clinical data collection over a 2-week period. The primary aim is to identify internationally relevant, modifiable surgical practices (in ter

Measurement of pion, kaon and proton production in proton-proton collisions at [Formula: see text] TeV.

The measurement of primary [Formula: see text], [Formula: see text], [Formula: see text] and [Formula: see text] production at mid-rapidity ([Formula: see text] 0.5) in proton-proton collisions at [Formula: see text][Formula: see text] 7 TeV performed with a large ion collider experiment at the large hadron collider (LHC) is reported. Particle identification is performed using the specific ionisat

Endoplasmic reticulum function in dendrites and dendritic spines of hippocampal neurons

Popular Abstract in Swedish Till och med kroppens allra enklaste celler är så avancerade att vi inte förstår i detalj hur de fungerar eller hur de påverkar kroppen. Nervceller tillhör kroppens mer avancerade celler och vi får erkänna att all den kunskap vi har om dem är mindre än vad som finns att veta. Komplexiteten hos hjärnan är mångfalt större för nervcellerna kommunicerar blixtsnabbt med varaIn the hippocampus, dendritic spines are compartmentalized postsynaptic micro-domains in the excitatory synapse. Subsets of bigger and mushroom-shaped hippocampal dendritic spines contain tubules and cisterns of endoplasmic reticulum (ER) that are connected to the soma and dendrites of the neuron. These ER containing spines differ in their ability to retain ER. We hypothesized a functional couplin

Is There Really Something Which Might Be Called a 'Self-Demonstrating Picture' : Even Within Scientific Imagery? Some Observations on a Double Illusion of Communication

I will propose some ideas about such pictures claiming to be self-demonstrating or selfillustrating, mostly using some classical anatomy illustrations. Based on these you may say that the anatomy seems to create a remarkable, realistic pictorial code, which casts together in one single, selfdemonstrating shape, an object of knowledge with the properties of the natural object itself. This is the pa

From Speed Profile Data to Analysis of Behaviour

Classification of speed profiles is necessary to allow interpretation of automatic speed measurements in terms of road user behaviour. Aggregation without considering variation in individual profile shapes easily leads to aggregation bias, while classification based on exogenous criteria runs the risk of loosing important information on behavioural (co-) variation. In this paper we test how three

Soil moisture variations affect short-term plant-microbial competition for ammonium, glycine, and glutamate.

We tested whether the presence of plant roots would impair the uptake of ammonium ([Formula: see text]), glycine, and glutamate by microorganisms in a deciduous forest soil exposed to constant or variable moisture in a short-term (24-h) experiment. The uptake of (15)NH4 and dual labeled amino acids by the grass Festuca gigantea L. and soil microorganisms was determined in planted and unplanted soi

Human native lipoprotein-induced de novo DNA methylation is associated with repression of inflammatory genes in THP-1 macrophages

Background: We previously showed that a VLDL-and LDL-rich mix of human native lipoproteins induces a set of repressive epigenetic marks, i. e. de novo DNA methylation, histone 4 hypoacetylation and histone 4 lysine 20 (H4K20) hypermethylation in THP-1 macrophages. Here, we: 1) ask what gene expression changes accompany these epigenetic responses; 2) test the involvement of candidate factors mediat