Neruons; regulators of CNS inflammation
Neurons have been neglected as cells with major immune regulatory function. Here, we present novel data demonstrating that neurons are highly immune competent and play crucial role in regulation of T cell response and CNS inflammation. Neurons induce proliferation of activated CD4+T cells via B7-CD28 and TGF-?1-TGF-?R signaling pathways with amplification of TCR signaling and increased phosphoryla