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QM/MM study of the catalytic reaction of potato epoxide hydrolase

Epoxide hydrolases are essential enzymes that convert epoxides into 1,2-diols, contributing to detoxification, metabolism, and signaling in a wide range of organisms. In this study, we employed hybrid quantum mechanics/molecular mechanics (QM/MM) calculations to investigate the catalytic mechanism of potato epoxide hydrolase 1 (StEH1), specifically focusing on the hydrolysis of trans-stilbene oxid

Quantum refinement with electron diffraction and X-ray free-electron laser data: comparative study of ribonucleotide reductase dimetal site

Quantum refinement (QR) is an approach in which the empirical restraints used in standard structural refinement to ensure that the details of the structure, e.g. bond lengths and angles, make chemical sense are replaced by more accurate quantum mechanical calculations for a small but interesting part of the structure. QR has previously been used for X-ray and neutron crystallography, cryogenic e

Reading by Listening in Academia : Students with ADHD's Use of Audioboks and Text-to-Speech in Higher education

While the so-called “audiobook boom” has yet to reach academic publishing, thegrowing number of students with print disabilities entering higher education isprompting an increase of academic reading materials in audio formats, such asaudiobooks and text-to-speech software. Despite this, little research exists on students’actual use of audiobooks and text-to-speech in their studies, especially amon

A retrospective cohort study of clinical characteristics and healthcare contacts in Sweden prior to suicide in individuals with heart disease

Background: Heart diseases are among the leading causes of disease burden worldwide with often a large impact on the lives of the affected individuals. The association between heart disease and depression is well-known and elevated suicide risk has been demonstrated in several types of heart disease. The aim of this study was to investigate what health care contacts individuals with heart disease

Mapping forest felling activities in Latvia from Sentinel-2 satellite imagery using machine learning

This thesis develops and evaluates a Random Forest (RF) machine learning classification framework for detecting clear-cut forest felling events using Sentinel-2 multispectral satellite data. While RF classification is widely applied in forest monitoring, its performance for operational clear-cut detection in Latvian semi-boreal forests remains insufficiently studied. This study aims to assess the

Scaling the implementation of circular economy requirements in public procurement for construction projects

Public procurement has the potential to serve as a strategic driver for circular economy implementation and urban sustainability transitions. Purpose: This study explores how municipalities incorporate circular requirements into construction project procurement processes. The aim is to identify practical strategies that support circular implementation in construction projects. Methodology: Using a

Horizontal inter-municipal collaboration driving innovation through circular public procurement

Horizontal collaboration in municipalities is increasingly promoted as a means to foster innovation in circular construction through circular public procurement (CPP), yet the diffusion of such practices remains uneven. Drawing on a qualitative study of Swedish municipalities, this paper explores how municipalities collaborate horizontally to address the challenges associated with implementing CPP

Novel GH115 xylan α-1,2-glucuronidases with distinct preferences for xylan-derived oligomers and polymers

Natural polymers are promising sustainable materials for diverse applications. Xylans, major components of hemicellulose, exhibit origin-dependent substitution patterns that determine their physicochemical properties. Targeted enzymatic modification of these substituents offers a mild and precise approach for tailoring the polymer's characteristics. Glucuronidases (EC 3.2.1.139) and xylan α-1,2-gl

The benefits of certifying buildings in operation

Until recently, only certifications for new buildings were available, but over recent years, a growing interest in certifying buildings in operation has emerged. These certifications focus on aspects like the indoor environment, occupant well-being and climate impact and seek to enhance the environmental performance of buildings through effective operation and management. This study aimed to ident

Levnadsbanor och rörlighetsmönster : En introduktion

Research in the field of historical demography and related areas have in recent decades made increasing use of longitudinal population databases. This research has mainly focused on rural populations before 1900. This book belongs to a movement that seeks to bridge the gap in historical demography by adding urban populations from the twentieth century. The book is made up of individual chapters re