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Genetic determinants underlying most human blood groups are now clarified but variation in expression levels remains largely unexplored. By developing a bioinformatics pipeline analyzing GATA1/Chromatin immunoprecipitation followed by sequencing (ChIP-seq) datasets, we identify 193 potential regulatory sites in 33 blood-group genes. As proof-of-concept, we aimed to delineate the low-expressing com
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Rapid global warming is severely impacting Arctic ecosystems and is predicted to transform the abundance, distribution and genetic diversity of Arctic species, though these linkages are poorly understood. We address this gap in knowledge using palaeogenomics to examine how earlier periods of global warming influenced the genetic diversity of Atlantic walrus (Odobenus rosmarus rosmarus), a species
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Vårt samhälle står inför dubbla utmaningar vad gäller att ställa om till mer hållbar energi- och resursförbruking, och mer hållbara ekonomiska och sociala system, inklusive att minska växande ojämlikheter. För att nå Sveriges klimatmål samt Agenda 2030-målen måste resurs- och energiförbrukningen signifikant reduceras. Samtidigt finns det väldigt lite evidens för att denna reducering kan ly
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In this paper we discuss some recent and widely debated views of belief, comparing them with Ramsey’s, as it was developed in his classic papers and the posthumously published work On Truth. This paper is not purely historical. Modern views of belief, especially the theory of Shah and Velleman are examined, and it is shown that Ramsey’s views are relevant to the current discussion. Ramsey’s theory
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»Molnets materialitet« blottlägger stegvis det digitala molnets materiella förutsättningar.
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In drug discovery, it is of utmost importance to accurately calculate the free energies of binding ligands to various protein targets, such as enzymes and receptors. We have assessed and used computational tools for this aim, most of them based on molecular dynamics (MD) simulations. We mostly used molecular mechanics (MM) in order to model the protein—ligand interactions, which is more approximat
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The retail industry faces a multitude of complex sustainability challenges, which calls for transformational change. While the retail industry is a major driver of production and consumption patterns, it also offers significant potential to reduce global greenhouse gas emissions. Notably, logistics services, such as warehousing, delivery, and returns, have gained vital importance in retail due to