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Objectives To investigate changes in analgesic use before and after supervised exercise therapy and patient education in patients with knee or hip osteoarthritis (OA).Methods We recruited 16 499 of 25 933 eligible patients (64%; mean age 64.9; SD 9.6; 73% women) from the Good Life with osteoArthritis in Denmark (GLA:D) registry. Change in proportions of analgesic users (categorised according to an

Chagas disease (CD), caused by Trypanosoma cruzi, is a neglected tropical illness affecting 6-8 million people in Latin America. Reaching scholarly consensus on the host response to T. cruzi infection remains a significant challenge, primarily due to substantial heterogeneity in outcomes driven by both the choice of animal model and the infecting parasite's discrete typing unit (DTU). This varia

Cas12e proteins (formerly CasX) form a distinct subtype of Class II type V CRISPR-Cas effectors. Recently, it was shown that DpbCas12e from Deltaproteobacteria and PlmCas12e from Planctomycetes can introduce programmable double-stranded breaks in mammalian genomes. Thus, along with Cas9 and Cas12a Class II effectors, Cas12e could be harnessed for genome editing and engineering. The location of cle

CRISPR-Cas defense systems opened up the field of genome editing due to the ease with which effector Cas nucleases can be programmed with guide RNAs to access desirable genomic sites. Type II-A SpCas9 from Streptococcus pyogenes was the first Cas9 nuclease used for genome editing and it remains the most popular enzyme of its class. Nevertheless, SpCas9 has some drawbacks including a relatively lar

This article analyses the industrial enterprise of the Dutch-born brothers Abraham and Jakob Momma-Reenstierna and their investments in Sápmi and the upper parts of the Torne River Valley, northern Sweden, during the second half of the seventeenth century. The aim is to explore the driving forces behind the industrial projects of the two brothers in a larger global and colonial context. With inspi

Fishes of the genus Pterois possess spines that provoke intense pain, which can last for weeks. Since the first toxicological description of their spine venom, a significant amount of research has been published regarding their biochemical characterization. This minireview presents research published from 1959 to 2024 on bioactive substances found in Pterois species. Pterois venom mainly contai

This article uses the elemental concepts of earth, water and fire to examine the production, use and control of space in the seventeenth-century Wrangel estate at Skokloster in central Sweden. Using a relational approach, the paper discusses how the elements symbolically express a part of the baroque aesthetic, how they were emphasised or pinned down as part of an economic asset, and how they reac

Smoothing stones from Sami contexts in the 18th and 19th centuries. Smoothing stones of green stone/field stone are sometimes found in both Sámi and non-Sámi contexts from the Iron age and the Medieval period. Usually they are associated with leather or textile production. This paper discusses the findings of natural smoothing stones at three Sámi dwellings in Hälsingland and Gästrikland, central

Explicit finite element schemes are extensively used in industrial applications characterised by elevated strain rates and complex contact interactions. A central challenge in such simulations is the achievement of mesh-independent results while accurately capturing damage localisation and evolution. Gradient-enhanced damage models provide a robust regularisation framework. However, using a microm

Clinical characteristics.Spinocerebellar ataxia type 4 (SCA4) is a progressive neurologic disease characterized by cerebellar involvement (gait ataxia, balance disturbances, eye movement abnormalities), brain stem involvement (dysarthria, dysphagia), sensory neuropathy, motor neuron involvement (muscle wasting and spasticity), autonomic dysfunction (especially orthostatic hypotension), and cogniti

The finite element (FE) method is one of the approaches available for solving different types of partial differential equations in the various fields of physics, such as solid mechanics, heat transfer, and electromagnetics. Visualization and manipulation of results play a crucial role in the interpretation and analysis of simulation results, especially when complex and advanced problems are consid

Data-driven mechanics offers great potential in engineering applications, where the efficient simulation of complex and, in particular, path-dependent material behavior is often challenging. Within this approach, conventional material models are replaced by data sets containing snapshots of stress, strain and the history of both assumed to be sufficiently accurate representations of the underlying

An elderly, right-handed, male patient presented to the emergency department at a middle sized hospital with a few hours' history of mild confusion and a difficulty expressing himself verbally. Past medical history consisted of hypertension and cured hairy cell leukemia. CT scan of the brain showed a 5 cm infarction in the left occipital lobe, and a corresponding P2 occlusion was seen. The patient

I dagens samhälle kan människor med sårbarhetsfaktorer, såsom ålderdom eller respiratoriska sjukdomar, riskera att dö när de utsätts för virusinfektioner. Det figurerar ständigt olika influensavarianter bland oss som vissa kan tillfriskna från utan några mediciner, men de individer som har en uttalade sårbarhet behöver antivirala läkemedel för att bekämpa viruset. Ett av dessa läkemedel är ZanamivIn this study, a novel route to synthesising Zanamivir have been accomplished. In the past two decades, many scientists have struggled to find a green and step-economical route to synthesising Zanamivir. None have succeeded to insert guanidine; thus, relying on amination and reduction with explosive azido reagents, causing the synthesis to be far too long and hazardous. Our aim was to shorten the

In manufacturing, thermomechanical processes such as static annealing and hot working are commonly used to tailor the microstructure of metals to achieve favourable macroscopic material properties that meet specific application requirements. To improve sequential manufacturing processes and to accurately predict the microstructural changes of the material along the process chain, physically motiva