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Developing radiation tumor biomarkers that can guide personalized radiotherapy clinical decision making is a critical goal in the effort towards precision cancer medicine. High-throughput molecular assays paired with modern computational techniques have the potential to identify individual tumor-specific signatures and create tools that can help understand heterogenous patient outcomes in response

This study presents a simulation-based framework for evaluating energy renovation strategies across European building typologies and climate zones. A factorial parametric approach was used to simulate over 800,000 combinations of envelope assemblies, HVAC systems, and shading controls for three archetypes (single-family, multi-family, office) across five European climate zones under both current a

BACKGROUND: The isolation of cell-free DNA (cfDNA) from the bloodstream can be used to detect and analyze somatic alterations in circulating tumor DNA (ctDNA), and multiple cfDNA-targeted sequencing panels are now commercially available for Food and Drug Administration (FDA)-approved biomarker indications to guide treatment. More recently, cfDNA fragmentation patterns have emerged as a tool to inf

The International Agency for Research on Cancer has recently classified occupational exposure as a firefighter as carcinogenic (group 1A). Even though the occupation of firefighter is associated with high exposure to pollutants, it is challenging to carry out exposure studies to assess health risks due to the extreme conditions associated with firefighting. Routine monitoring of occupational expos

Introduction: The first-line evidence-based treatment for chronic pain is multidisciplinary treatment involving pain-focused CBT. Studies have shown that changes in psychological flexibility (PF) during pain-focused CBT positively mediatesoutcomes, even when the treatment does not specifically target PF. While CBT and PF-based treatments for chronic pain yield small to moderate, but clinically mea

In collisions between heavy nuclei, such as those at the Large Hadron Collider (LHC) at CERN, hydrodynamic models have successfully related measured azimuthal momentum anisotropies to the transverse shape of the collision region. For an elliptically shaped interaction area, the hydrodynamic pressure gradient is greater along the minor axis, resulting in increased particle momentum in that directio

Coastal port cities are key regions for carbon emissions (CEs) research in China, due to their industrial density, frequent transportation, and diverse human activities. Taking Ningbo City as a case study, this study employed a top-down accounting method and integrated multiple sources of geospatial data to reveal the spatiotemporal distribution characteristics of CEs from four sectors, including

Background: Approximately 40% of cancer patients/survivors develop chronic cancer-related pain (CRP), which is often associated with greater levels of fatigue and cancer worry, all of which are associated with poorer functioning, wellbeing, and greater healthcare costs. Psychological Flexibility (PF) refers to one’s level of openness to and acceptance of physical/emotional experiences and willingn

Widespread vegetation changes have been evidenced by satellite-observed long-term trends over decades in vegetation indices (VIs). However, many issues can affect the derived VIs trends, among which the inherent difference between VIs calculated from the same input reflectance has not been investigated. Here, we compared global long-term trends in six widely used RED-NIR (near-infrared)-based VIs

BACKGROUND: Obesity represents a significant public health challenge, particularly in the context of coexisting chronic diseases and multi-morbidity. In Spain, and specifically in Catalonia, primary care plays a central role in prevention and management, yet barriers such as weight-related stigma can compromise care delivery.AIM: To evaluate the current state of obesity prevention and management w

Background: Low-molecular-weight heparin (LMWH) is recommended for thromboprophylaxis in adult intensive care unit (ICU) patients. Despite its widespread use, there is insufficient evidence on the optimal dose, and there appears to be practice variation. Determining the LMWH dosing strategy that most effectively balances the risks of venous thromboembolism (VTE) and bleeding may improve outcomes i

Introduction: Preclinical studies have demonstrated the ability of FLASH irradiation to expand the therapeutic window by sparing normal tissues. The heart is a critical organ at risk in patients receiving radiotherapy for thoracic cancers. This study aimed to quantify the cardiac sparing effects of photon FLASH delivered as single (FLASH) or FLASH split dose (FSD) exposures. Methods: Female C57BL/

Emerging evidence and clinical practice guidelines have highlighted that obesity, defined as a chronic disease characterised by excess or dysfunctional adipose tissue, may not be accurately measured or understood by solely relying on body mass index (BMI) which is a measure of size not functionality. An alternative to BMI, as proposed in the Canadian Adult Obesity Management Guideline, is the use

Hydrodeoxygenation (HDO) is a catalytic process applied for the reduction of oxygen levels in hydrocarbons from bio-derived feedstock as part of the processing into renewable fuel. The MoS2-based hydrotreating catalysts, currently being applied for the HDO reaction, are exposed to a complex environment consisting of O-rich hydrocarbons and water, which adversely impacts the state and stability of

Weight stigma negatively impacts people with higher weights across the lifespan as well as social contexts and can lead to weight discrimination. As weight is not a protected identity in Canadian human rights legislation, it is important to better understand how weight discrimination is being argued in Canada’s legal system. The purpose of this environmental scan was to examine and describe Canadi

Background: Obesity is a chronic disease linked to over 200 health conditions, reduced quality of life, and increased mortality. Despite the availability of multimodal treatments, there is a lack of standardised, patient-centred outcome measures to effectively assess and improve clinical care. This project aimed to define a core set of standardised outcome measures for adults with obesity, incorpo