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Background: Available fluid biomarkers, neuroimaging techniques, and clinical assessments may enhance prediction of conversion to secondary progressive multiple sclerosis (SPMS). Objectives: : To identify robust real-world predictors of MS progression in the literature. Methods: : A systematic review was conducted in EMBASE. A total of 20,338 MS patients from 64 eligible studies were included. A p

The glioblastoma (GBM) microenvironment undergoes adaptations to support tumor progression, including a dysregulated extracellular matrix, with altered heparan sulfate (HS) proteoglycans. We investigated N-deacetylase/N-sulfotransferase-1 (NDST1) because NDSTs are initial modifying enzymes of HS biosynthesis and have key roles in designing the HS sulfation pattern. This, in turn governs interactio

Let e ⊂ ℝ be a finite union of disjoint closed intervals. In the study of orthogonal polynomials on the real line with measures whose essential support is e, a fundamental role is played by the isospectral torus. In this paper, we use a covering map formalism to define and study this isospectral torus. Our goal is to make a coherent presentation of properties and bounds for this special class as a

The effect of the phase constitution of BCC/B2, FCC, Cr7C3 and their microstructural attributes are conspicuous on the hardness properties of AlCoCrFeNi HEAs [1]. The correlation of unsolicited C and O contaminant with process parameters (milling duration/rpm) and process control agent (PCA) categorically established that contamination increases with duration of mechanical alloying (MA) [2] . It i

With the rapid evolution of semiconductor technology and the growing demand for high-performance, low-power System-on-Chip solutions, the design of efficient and scalable on-chip interconnect architectures has become a critical challenge in modern ASIC development. This thesis focuses on design space exploration of replacing multiple ARM CoreLink NIC-400 crossbar-based interconnects with a unified

Power amplifiers play a crucial role in wireless communication systems. However, they can achieve high efficiency only when operating in the nonlinear region. To maintain linear output while operating in this region, several techniques have been developed, among which digital pre-distortion (DPD) is one of the most widely used. In this thesis, we designed and analyzed a digital predistortion (DPD)

Our study examined the chemical composition of fluvial and eolian sediments at the Velika Vrbica multisection, located on the bank of the Danube River in eastern Serbia, within the westernmost part of the lower Danube (Dacian) Basin. The multisection comprises two discrete sections: an older 2.7 m thick fluvial section, and a younger 11.2 m thick loess-paleosol sequence (LPS). These are exposed al

Cutting edge preparation is crucial in metal cutting as the edge geometry significantly influences both the material removal process and tool life. However, an analytical model that can physically describe the cutting edge preparation process has not yet been established. Taking the wet abrasive jet machining (WAJM) method as an example, the following questions always remain: Why does WAJM always

Lysine acetylation, once viewed primarily as a histone mark, is now recognized as a widespread regulator of protein function. Recent breakthroughs in chemical labeling, isotopic tagging workflows, and data-independent acquisition mass spectrometry enable precise, site-specific quantification of acetylation stoichiometry. This quantitative “acetylomics” approach reveals a “rheostat” model, where mo

Multi-electron donation remains a challenge for CO2 photocatalytic conversion to multi-electron products due to the efficient Auger recombination or annihilation at multiple excitation conditions for conventional molecules or semiconductor photocatalysts. In this paper, we demonstrated possible multi-electron donation within a quantum dot (QD)/metal complex hybrid photocatalyst system when multipl

A causal inference framework was developed to investigate crop responses to agricultural drought by integrating meteorological data, Sentinel-2-derived data, and soil property maps. To account for crop rotation, soil, and topographical variables, propensity score matching was employed to estimate drought-induced yield losses at the field level for selected periods. The Plant Phenology Index (PPI)

This is a contribution written for aspiring teachers of religionskundskap. It depicts what it means to grow up as a Buddhist, including reflections on childhood in Buddhist early sources and the childhood of the historical Buddha. It starts out with looking at children growing up among Buddhists and includes, in the end, South Asian Buddhist child monks as well as American and European perspective

Peatlands are vital ecosystems that regulate global carbon storage and hydrology, driven by waterlogged conditions that foster organic matter accumulation. However, disentangling the interactions between climate, hydrology, and tree growth in peatlands remains challenging. To investigate these relationships, we developed a 117-year ring width (RW) chronology (1902–2019) and complementary intra-ann

This interdisciplinary thesis examines the nexus of memory, war, and digitality inthe context of the Russian invasion of Ukraine. Since 2014, the unfolding Russianwar against Ukraine has epitomised how rapid technological developments haveprofoundly altered the ways in which warfare is depicted, perceived, and waged intoday’s world. These transformations have enabled new forms of engagement withwa