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In the concluding chapter, we outline the major findings from the eleven book chapters by connecting them to one another. We come back to the triadic delegation and accountability relationship between candidates, voters and parties that were developed based on principal–agent theory, and emphasise the most relevant findings of this book that inform this triad. The chapter also takes a critical sta
The paper focuses on analysis of macro‐ and micromorphological characteristics of relict slope deposits in Serra da Estrela (Portugal) to understand the significance of different slope processes and paleoenvironmental settings. Micromorphology is a useful sedimentology technique allowing significant advances compared to macroscopic techniques. Results show that different processes are involved in
Big Science is costly and complex, and historical evidence seems to suggest that projects often get delayed and more expensive than planned. On the basis of several studies of large infrastructures such as railroads and bridges, the Danish geographer Bent Flyvbjerg has proposed that there is an “iron law” of megaprojects, meaning that they almost without exception turn out more expensive and more
This thought-provoking book expands on the notion that Big Science is not the only term to describe and investigate particularly large research projects, scientific collaborations and facilities. It investigates the significant overlap between Big Science and Research Infrastructures (RIs) in a European context since the early twenty-first century. Contributions to this innovative book not only au
Purpose: The accuracy of analytical dose calculations (ADC) and dose uncertainties resulting from anatomical changes are both limiting factors in proton therapy. For the latter, rapid plan adaption is necessary; for the former, Monte Carlo (MC) approaches are increasingly recommended. These, however, are inherently slower than analytical approaches, potentially limiting the ability to rapidly adap
Patients with diffuse large B-cell lymphoma (DLBCL) who fail to complete planned treatment with R-CHOP due to toxicity are sparsely described. We investigated the extent of failure to complete treatment (six cycles or more, or three cycles + RT for patients with stage I disease) with R-CHOP for reasons unrelated to non-response, the determinants of such failure and the outcome among these patients
Studies on sugar intake and its link to cardiometabolic risk show inconsistent results, partly due to dietary misreporting. Cost-effective and easily measured nutritional biomarkers that can complement dietary data are warranted. Measurement of 24-h urinary sugars is a biomarker of sugar intake, but there are knowledge gaps regarding the use of overnight urine samples. We aim to compare (1) overni
Instruments play an essential role in creating research data. Given the importance of instruments and associated metadata to the assessment of data quality and data reuse, globally unique, persistent and resolvable identification of instruments is crucial. The Research Data Alliance Working Group Persistent Identification of Instruments (PIDINST) developed a community-driven solution for persisten
