Filtyp
Increasingly social activists, journalists and policy makers have expressed concern over the proliferation of conspiracy theories in the public space. There is a growing fear of their impact on social cohesion and democracy, their power to erode trust in state institutions and science. These concerns often come with an expectation that it is the responsibility of academics to engage with conspirac
Ketamine is a common anesthetic used in human and veterinary medicine. This drug has recently received increased medical and scientific attention due to its indications for neurological diseases. Despite being applied for decades, ketamine’s entire metabolism and pharmacological profile have not been elucidated yet. Therefore, insights into the metabolism and brain distribution are important towar
Aims: This study aimed to investigate the additional value of global longitudinal strain (GLS) on top of left ventricular ejection fraction (LVEF) in long-term risk prediction of combined death and heart failure (HF) re-hospitalization after acute coronary syndrome (ACS). Method and results: This retrospective study included patients admitted with ACS between 2008 and 2014 from the three participa
Background and purpose: Pyruvate dehydrogenase complex deficiency is in up to 90% caused by pathogenic variants in the X-linked PDHA1 gene. We aimed to investigate female relatives of index patients with PDHA1-related disease to (i) describe the prevalence of female PDHA1 carriers, (ii) determine whether they had symptoms and signs, and (iii) delineate the associated phenotype. Methods: In a natio
In 1946, one year after the atomic bombings of Japan, Palestinian thinker ʿAli Rashid Shaʿath (1908–1967) published a book entitled Min al-binsilin ila al-qunbula al-zarriya (From Penicillin to the Atomic Bomb). An accessible work of popular science, it con- tains highly optimistic reflections on the future and predicts the following two events as a result of nuclear technology and energy: a worke
Context. Complex models recently became available for studying the dynamics of disk galaxies such as the Milky Way (MW). These models include the global dynamics from dwarf satellite galaxies, dark matter halo structure, gas infall, and stellar disks in a cosmological context. Aims. We use a MW model from a suite of high-resolution hydrodynamical cosmological simulations named GARROTXA to establis
Plant pathogens are challenged by host-derived iron starvation or excess during infection, but the mechanism of plant pathogens rapidly adapting to the dynamic host iron environments to assimilate iron for invasion and colonization remains largely unexplored. Here, we found that the GATA transcription factor SreC in Curvularia lunata is required for virulence and adaption to the host iron excess e
Climate change risk assessment studies focus on identifying and analyzing different risks considering several climate change scenarios and on evaluating the cost-effectiveness of different adaptation measures. However, risk acceptability is often not reflected on in the context of climate change risk studies. Noting that the different climate change scenarios depict drastically contrasting images
The overall aim of this thesis was to investigate parents’ experiences and satisfaction with family-centered care (FCC)when their child was cared for at a pediatric intensive care unit (PICU). To obtain a deeper understanding of parents’experiences and satisfaction, two qualitative studies were conducted (Papers I and III). For Paper I, 10 individualinterviews were conducted two years after their
Industry 4.0, with its focus on flexibility and customizability, is pushing in the direction of wireless communication in future smart factories, in particular, massive multiple-input-multiple-output (MIMO) and its future evolution of large intelligent surfaces (LIS), which provide more reliable channel quality than previous technologies. At the same time, network slicing in 5G and beyond systems
Mixed-effects models are used to describe the inter-patient variability in drugs. Modeling of these variabilities include both fixed and random effects. Fixed effects relate covariates such as age and weight to compartment volumes and clearances, whereas random effects account for unexplained variability. Traditionally, the development of fixed effects models is an inefficient process where covari
Purpose: The apparel and textile sector poses a significant environmental challenge due to its substantial contribution to pollution in the form of air, water and soil pollution. To combat these issues, the adoption of sustainable practices is essential. This study aims to identify and analyse the barriers that hinder the progress of sustainability in the apparel and textile industry. By consultin
Kidney transplantation, the gold-standard therapeutic approach for patients with end-stage kidney disease, offers improvement in patient survival and quality of life. However, broad sensitization against human leukocyte antigens often resulting in a positive crossmatch against the patient’s living donor or the majority of potential deceased donors in the allocation system represents a major obstac
Understanding the evolutionary processes that influence fitness is critical to predicting species' responses to selection. Interactions among evolutionary processes including gene flow, drift and the strength of selection can lead to either local adaptation or maladaptation, especially in heterogenous landscapes. Populations experiencing novel environments or resources are ideal for understanding
Background: Person-centered care (PCC) is gaining increased attention. PCC concerns the whole person behind the disease and can improve care for people with long-term conditions such as multiple sclerosis (MS) and Parkinson’s disease (PD). However, there is a lack of tools to assess PCC from the patients’ perspective, particularly in outpatient care. The Person-Centered Care instrument for outpati
