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Epigenetic drift, which is gradual age-related changes in DNA methylation patterns, plays a significant role in aging and age-related diseases. However, the relationship between exercise, epigenetics, and aging, and the molecular mechanisms underlying their interactions are poorly understood. Here, we investigated the relationship between cardiorespiratory fitness (CRF), epigenetic aging, and prom
Gamma-ray observations of the astrophysical neutrino sources are fundamentally important for understanding the underlying neutrino production mechanism. We investigate the Cherenkov Telescope Array (CTA) ability to detect the very-high-energy (VHE) gamma-ray counterparts to the neutrino-emitting Active Galaxies. The CTA performance under different configurations and array layouts is computed based
Atmospheric measurements of the short-lived radioactive noble gas radon-222 (222Rn) have many applications. Its concentrations are driven by atmospheric mixing as well as seasonal variations, which follow the seasonality of 222Rn exhalation from continental soils, with lower values during the wet winter and spring months compared to more dry summer conditions. Hence, it can be used as a tracer to
Here, we use carbon dioxide (CO2), methane (CH4), carbon monoxide (CO), nitrous oxide (N2O) and radon (222Rn) data from the Saclay ICOS tall tower in France to estimate CO2, CH4 and CO fluxes within the station footprint from January 2017 to October 2024 and N2O fluxes from February 2019 to October 2024 using the Radon Tracer Method (RTM). We first performed a sensitivity study of this method appl
Cross-system fluxes of aquatic insects rich in omega-3 long-chain polyunsaturated fatty acids (ω-3 LC-PUFAs), specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may subsidise insectivorous vertebrates that are suffering due to terrestrial insect declines. The benefits of high ω-3 LC-PUFA diets, such as improved growth and immunocompetence, have previously been demonstrated fo
Background: This study compared levels of physical activity (PA) and sedentary behavior (SB) in adults with and without chronic diseases or multimorbidity, acknowledging sociodemographic factors. Methods: A cross-sectional analysis was conducted with data from 27,890 participants (52% women), aged 50–64, from the Swedish CArdioPulmonary bioImage Study cohort. Over 1500 chronic diseases were includ
The Cherenkov Telescope Array Observatory (CTAO) is the next-generation ground-based gamma-ray observatory currently under construction. It will improve over the current generation of imaging atmospheric Cherenkov telescopes (IACTs) by a factor of five to ten in sensitivity and it will be able to observe the whole sky from a combination of two sites: a northern site in La Palma, Spain, and a south
Despite the advancement in background rejection techniques, observation of the very-high-energy gamma-ray sky by imaging atmospheric Cherenkov telescopes (IACTs) are subject to an irreducible background from gamma-like hadron- or electron-induced air showers. The determination of this residual background is crucial for accurate spectral and spatial measurements. The Cherenkov Telescope Array (CTA)
BACKGROUND: Seizure duration during electroconvulsive therapy (ECT) correlates with treatment efficacy and may be influenced by depth of anaesthesia. The Patient State Index (PSi), derived from processed EEG, offers a potential method to monitor depth of anaesthesia during ECT. This study examined the correlation between pre-ictal PSi and EEG-seizure duration.METHODS: In this prospective observati
Background/Objectives: Older patients are more susceptible to the process of understanding and retrieving information. To provide adequate preoperative information, reduce their vulnerability and anxiety, and thereby facilitate pre-, intra-, and postoperative care, the adoption of new information technologies is essential. This study aimed to explore elderly patients' experiences and perceptions o
For the development of a joint European capacity for monitoring CO2 emissions, we created the framework “CO2 Monitoring Challenges City Mapbooks v1.0” (CMC-CITYMAP). It includes a Jupyter notebook tool (Storm et al., 2025a, https://doi.org/10.18160/P8SV-B99F) which we use to characterise and cluster cities based on aspects relevant for different CO2 monitoring challenges. These include:a. determin
This study aimed to test and validate a dual-time-window (DTW) protocol for 6-(fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]MK6240) dynamic PET imaging in experimental datasets acquired in human subjects. Methods: DTW protocols were tested and validated in datasets previously collected in 25 participants: 13 were cognitively normal, 10 had mild cognitive impairment, and 2
OBJECTIVES: Opioid-free anesthesia (OFA) is a promising alternative to traditional opioid-based anesthesia. Research indicates that OFA reduces postoperative opioid consumption and related adverse effects while maintaining effective pain control and patient safety. Despite these benefits, clinical adoption of OFA remains limited, possible due to gaps in evidence. To bridge this knowledge gap, a we
BACKGROUND: Monitoring of vital signs is essential in anaesthesia care and plays a key role in preventing adverse events. Technological innovation is recognised as an important factor in enhancing patient safety. Smart glasses represent a novel tool that may support anaesthesia professionals in monitoring vital signs; however, their practical use and user experiences in anaesthesia care remain ins
The increasing presence and activities of people in both urban environments and non-urban areas result in the exposure of many wild animal populations to persistent human disturbance. As a response, individuals in disturbed populations often become tolerant towards humans, which can have significant ecological and societal consequences, for example by affecting ecosystem services and human–wildlif
Micropollutants in wastewater can persist through conventional treatment, threatening ecosystems and human health through toxicity, bioaccumulation, and disruption of biological processes. Limited monitoring, due to cost and methodological challenges, allows these compounds to go undetected, potentially leading to long-term, irreversible impacts. To address this, modern wastewater treatment plants
The presence of pharmaceuticals, especially antibiotics, in aquatic environments can significantly contribute to the rise of antibiotic resistance, presenting a critical global public health challenge. This study investigates the presence of four selected antibiotics and an antiretroviral drug (nevirapine) in the Vaal River in South Africa. Grab samples collected at nine sampling sites across four
Background: Wrist osteoarthritis (OA) is mainly posttraumatic, affects younger individuals than other types of OA, and can lead to significant disability. The first-line treatment is patient education and exercise, but surgery may be considered if symptoms persist. A mini-invasive surgical approach for wrist OA is partial wrist denervation, which,in theory, alleviates pain by resecting sensory ner
