BackgroundTranscriptomic and genomic analyses of bladder cancer (BC) reveal a highly diverse disease stratified into molecular subtypes with distinct molecular features and biological behaviors. Intratumor heterogeneity (ITH) and plasticity can significantly impact diagnosis and patient management, yet their extent in BC remains highly debated. Here, we investigated whether the three main bladder

Despite the advent of advanced molecular prognostic tools, it is still difficult to predict the course of disease for cancer patients at the individual level. This lack of predictability is also reflected in many experimental cancer model systems, begging the question of whether certain biological aspects of cancer (eg. growth, evolution etc.) can ever be anticipated or if there remains an inheren

Introduction In type 2 diabetes (T2D), beta cell failure is often associated with islet inflammation driven by the innate immune response, with macrophages playing a significant role. However, the composition and phenotype of lymphoid immune cells in the islets of individuals with T2D have not been extensively studied. This study aims to characterize and compare the presence, phenotype, and freque

Examensarbetets titel: Myter som insats: En studie om hur spelbolag legitimerar sig genom myter i sin marknadsföring inom en kontroversiell bransch Seminariedatum: 03-06-2025 Ämne/kurs: FEKH29, Examensarbete i marknadsföring på kandidatnivå, 15 högskolepoäng Författare: Lo Lindstam, Lovisa Robertsson, Melvin Nilsson Handledare: Peter Svensson Fem nyckelord: Spelbolag, Legitimitet, Nyinstitutionell

Seminar date: June 2, 2025 Course: BUSN79, Business Administration: Degree Project in Accounting and Finance, 15 Credits. Authors: Ebba Flaten Jonsson and Julia Krusell Supervisor: Anna Häger Glenngård Examiner: Johan Dergård Five key words: Strategic Investment Decisions, Pre-Decision Control, Sustainability Strategic Investment Decisions, Judgement, Strategic Fit Purpose: The purpose of this pa

This study investigates the relationship between cornerstone allocation and IPO underpricing in the Swedish market, as well as the moderating role of valuation uncertainty on this relationship. Employing OLS and 2SLS frameworks on a sample of 429 Swedish IPOs from 2010 to 2024, we find evidence of a causal non-linear relationship between cornerstone allocation and IPO underpricing, taking the form

Anne Rice's Interview with the Vampire (1976) reshaped the vampire genre by combining Gothic horror with BDSM elements. The novel explores the tension between aesthetics and ethics, where violence is presented as both intimate and seductive. Key relationships, such as between Louis and Lestat, show power dynamics defined by submission and control. These dynamics are expressed through vivi

This paper investigates gender dynamics within a sixth-grade English as a Foreign Language (EFL) classroom (approximately 12-year-old students) in Sweden, focusing on how gender is performed and perceived by students and their teacher during classroom interactions. Grounded in the compulsory school curriculum’s mandate to actively promote and embody gender equality, and addressing the scarcity of

Vatten hittar alltid ett sätt att nå sin destination. Kan vi också göra det? Med tanke på de snabba klimatförändringarna och den ökade risken för kraftiga nederbördshändelser kan kommunerna i Sverige potentiellt stå inför stora utmaningar. Vad gör vi när det inträffar skyfall och har kommuner och medborgare vidtagit alla försiktighetsåtgärder för att minimera egendomsskador och hälsorisker? DeDue to rapid urbanization and industrialization, cities have been seen as one of the main contributors to climate change and its negative impacts in recent decades. Many of the Nordic countries have experienced an increased number of torrential rains and floods in recent years, resulting in both property and environmental damage as well as possible negative effects on the well-being of citizens. E

This study investigated how acoustical challenges, specifically changes in signal-to-noise ratio (SNR), affect the neural tracking of attended and ignored speech in individuals with hearing impairment. The analysis began with the speech envelope and was progressively extended by incorporating phonetic information as well as outputs from all layers of OpenAI’s Whisper model. The goal was to gain a

87 % av våra använda kläder bränns eller dumpas – kan digitala produktpass för textilier vända trenden? För att minska förbränningen och dumpningen av använda textilier måste återanvändningen och återvinningen öka. Digitala produktpass för textilier har möjlighet att stötta i dessa aktiviteter, men det finns oklarheter som måste redas ut för att produktpassen ska kunna användas på bästa sätt. ViThe textile industry generates large amounts of waste, most of which is incinerated or landfilled. To enhance circular practices, the Ecodesign for Sustainable Products Regulation will introduce digital product passports (DPPs) in the EU. The passports will collect data on textiles throughout their value chain and are expected to become mandatory by 2027. The existing research on the DPP usability

Kvantnyckeldistribution är ett alternativ till traditionella metoder för att distribuera krypteringsnycklar. Till skillnad från de traditionella metoderna är kvantnyckeldistribution säkert även mot kvantdatorer. Olika typer av fel i sändare och mottagares laboratorier kan dock påverka säkerheten hos systemet. Större och mer generella fel leder till sämre säkerhet. Information om nyckeln kan också With the rise of quantum computers that can break traditional key distribution protocols for cryptography, new methods are needed. In Quantum Key Distribution (QKD), quantum physics is used to create and distribute a secret key between honest parties. This thesis focuses on the well-known BB84 protocol. The sender (Alice) sends quantum states to the receiver (Bob) who measures the states. Alice’s

Quantum effects at the nanoscale offer significant potential for future device technologies. A quantum dot heat engine, for instance, is able to convert heat into electrical current. This thesis investigates the transport properties and current fluctuations in a single-level quantum dot heat engine operating in the sequential tunneling regime. Based on the existing experimental data, both the curr

ImportanceSyncope remains a diagnostic challenge despite advancements in testing and treatment. Cardiac syncope is an independent predictor of mortality and can be difficult to distinguish from other causes of transient loss of consciousness (TLOC).ObservationsThe cause of TLOC is often unclear, hospitalization criteria are ambiguous, diagnostic tests are frequently non-informative, and assessment

This thesis investigates the K±/(π+ + π−) yield ratio near Ξ − ¯Ξ pairs in pp collisions at mid-rapidity (|η| < 1) to distinguish between two competing models of strangeness enhancement: the rope hadronization model, implemented in PYTHIA, and the canonical statistical hadronization model, implemented in Thermal-FIST. The results from both models show strong agreement with experimental data from t

Chiral C3-symmetric molecules are an important class of compounds with applications in asymmetric catalysis and drug discovery. Few synthetic methods exist to synthesize this class of molecules in a step-economic and concise manner. This work explores a range of chemical transformations to functionalize the D3-symmetric (a,e,i)tribenzo(5,6,11,12,17,18) hexadehydro[12]annulene into C3-symmetric pla

The chaperone protein DNAJB6b exhibits intrinsic activity in inhibiting amyloid fibril formation, although the underlying mechanism remains unclear. A key region, comprising residues 132-183 and rich in serine and threonine residues, commonly referred to as the “S/T region”, has been shown to play a critical role in this function. While deletion of the S/T region does not disrupt the folding of DN