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Support in the context of allogeneic hematopoietic stem cell transplantation - The perspectives of family caregivers

Background and aim: Family caregivers are often involved in helping recipients during allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although the distress that often arises along the trajectory is evident to family caregivers, research on their perceptions of providing and receiving support is limited. The aim of this study was to explore family caregivers’ experiences of providin

On the Governance of Artificial Intelligence through Ethics Guidelines

This article uses a socio-legal perspective to analyse the use of ethics guidelines as governance tool in the development and use of artificial intelligence (AI). This has become a central policy area in several large jurisdictions, including China and Japan, as well as the EU, focused here. Particular emphasis is in this article placed on the Ethics Guidelines for Trustworthy AI published by the

Health-related quality of life after surviving an out-of-hospital compared to an in-hospital cardiac arrest : A Swedish population-based registry study

Background: Health-related quality of life (HRQoL) has been reported for out-hospital (OHCA) and in-hospital cardiac arrest (IHCA) separately, but potential differences between the two groups are unknown. The aim of this study is therefore to describe and compare HRQoL in patients surviving OHCA and IHCA. Methods: Patients ≥18 years with Cerebral Performance Category 1–3 included in the Swedish Re

Impacts of fuel quality on indoor environment onboard a ship : From policy to practice

Environmental considerations, concerning the negative impacts of ship exhaust gases and particles on ambient air quality, are behind the requirements of cleaner marine fuels currently applied in designated emission control areas (ECAs). We investigated the impact of a ship operating on two types of fuel on the indoor air quality onboard. Gaseous and particulate air pollutants were measured in the

A numerical study of heat transfer effects and aerodynamic noise reduction in superheated steam flow passing a temperature and pressure regulation valve

Steam is a common medium in thermal engineering. When it flows through a throttling element, the aerodynamic noise may occur due to the disturbance. In this investigation, superheated steam flowing through a Venturi tube, one of the main parts in a temperature and pressure regulation valve, at different thermal conditions is studied to analyze to effects of heat transfer on the acoustic power. Wit

Negative-ion/positive-ion coincidence spectroscopy as a tool to identify anionic fragments : The case of core-excited CHF3

We have studied the dissociation of the trifluoromethane molecule, CHF3, into negative ionic fragments at the C 1s and F 1s edges. The measurements were performed by detecting coincidences between negative and positive ions. We observed five different negative ions: F−, H−, C−, CF−, and F2 −. Their production was confirmed by the analysis of triple coincidence events (negative-ion/positive-ion/pos

Evaluation of penicillin G susceptibility testing methods for Staphylococcus lugdunensis

BACKGROUND: Staphylococcus lugdunensis belongs to the CoNS group, but is regarded to be more virulent than most other CoNS. It is also remarkably susceptible to antibiotics, including penicillin G. OBJECTIVES: To evaluate different methods for penicillin susceptibility testing, to assess penicillin susceptibility rates among S. lugdunensis and to describe the clinical presentation including antibi

The effect of maternal body mass index on duration of induced labor

Introduction: Obese primiparous women with induction of labor are at high risk for a cesarean section. There are contradictory results regarding time in induced labor in relation to maternal body mass index (BMI). It is important to characterize the course of induced labor to prevent unnecessary cesarean section. We aimed to evaluate whether the duration of labor was associated with maternal BMI i

Prediction of clinical diagnosis of Alzheimer’s disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 years

The strongest genetic risk factor for Alzheimer’s disease (AD) is the ε4 allele of Apolipoprotein E (APOE) and recent genome-wide association meta-analyses have confirmed additional associated genetic loci with smaller effects. The aim of this study was to investigate the ability of an AD polygenic risk score (PRS) and APOE status to predict clinical diagnosis of AD, vascular (VD), mixed (MD), and

Improving risk assessment in the European Food Safety Authority: lessons from the European Medicines Agency

The recent Regulation (EU) 2019/1381, published on the 6th September 2019, aims to improve the transparency and sustainability of the EU risk assessment in the food chain by amending the General Food Law Regulation (EC 178/2002) and a number of other regulations related to the food sector. This Regulation is introduced as a response to the Fitness Check of the General Food Law Regulation as well a

Quantification and detection of genetic risk factors in the familial aggregation of cancer : Habilitation thesis

SummaryCancer is a multifactorial inheritance disorder caused by a combination of small variations in genes, often acting together with environmental factors. GWASs provide a potential method to investigate the genetic basis of such complex diseases, but they are limited to two main classes of cancer susceptibility variants with different levels of risk and prevalence in the general population: ra

Health Literacy among Swedish Patients in Opioid Substitution Treatment : A Mixed-Methods Study

Background: Poor health and unmet healthcare needs is common among people with substance use disorder (SUD) including patients in opioid substitution treatment (OST). Low health literacy (HL) is associated with poverty, low education and physical limitations, but is unexplored in an OST context. Methods: Mixed-methods were used. Participants were consecutively recruited by clinic staff or research

Temperatures beyond the community optimum promote the dominance of heat-adapted, fast growing and stress resistant bacteria in alpine soils

Alpine soils are warming strongly, leading to profound alterations in carbon cycling and greenhouse gas budgets, mediated via the soil microbiome. To explore microbial responses to global warming, we incubated eight alpine soils between 4 and 35 °C and linked the temperature dependency of bacterial growth with alterations in community structures and the identification of temperature sensitive taxa

Geochronology, whole-rock geochemistry and Sr-Nd isotopes of the Bhanupratappur mafic dyke swarm : Evidence for a common Paleoproterozoic LIP event at 2.37–2.36 Ga in the Bastar and Dharwar cratons

Mafic dykes and dyke swarms in continental settings provide information on the evolution of the subcontinental mantle and can be key elements in the reconstruction of paleo-geographic settings of now separated crustal terranes. This study focuses on the petrogenesis and geochronology of mafic dykes of the WNW (~125°) trending Bhanupratappur swarm in the central Bastar Craton, central India. Dykes

Management of an outbreak of postpartum Streptococcus pyogenes emm75 infections

Background: Streptococcus pyogenes is a well-known cause of postpartum infections and is causing significant morbidity and mortality. Aim: To describe measures taken to control an outbreak of postpartum infections caused by S. pyogenes emm75 on a maternity ward. Methods: Patients presenting postpartum with signs and symptoms of infection were cultured for β-haemolytic streptococci with cervical sw