Filtyp
Bakgrund: Postpartumdepression är en allvarlig diagnos som drabbar 10-13% av nyblivna mödrar. För att möjliggöra tidig identifiering ska alla nyblivna mödrar i Sverige erbjudas screening med självskattningsskalan Edinburgh Postnatal Depression Scale (EPDS). Forskningen kring distriktssköterskors upplevelser av screeningen i Sverige är bristfällig. Syfte: Att belysa distriktssköterskors erfarenhete
Mitochondria are most known as producers of ATP and for their metabolic functions in eukaryotic cells. However, these are not the only roles of these organelles, as they also have the means to communicate with the nucleus. These signals going from mitochondria to the cell nucleus are termed mitochondrial retrograde signaling or regulation (MRR). In Arabidopsis thaliana, the master regulator of MRR
Sloth moths are highly-specialized for a life in a very close relationship with sloths – the adults live in the sloth fur and the larvae feed on the sloth faeces. They belong to the pyralid subfamily Chrysauginae (Insecta: Lepidoptera: Pyralidae). Although Pyralidae have been a focus of several molecular phylogenetic studies, including a few Chrysauginae genera, so far none of the three sloth moth
Bakgrund: En åldrande befolkning och ett ökat antal äldre personer som vårdas i kommunal primärvård, kräver att distriktssköterskor är trygga i att samtala om döden. Patienter uttrycker en önskan om att diskutera sina förväntningar i livets slutskede, men denna önskning blir inte alltid tillgodosedd. Syfte: Studiens syfte var att belysa distriktssköterskors erfarenheter av samtal om döden med pati
In vitro airway epithelial models play a crucial role in respiratory research, particularly for studying barrier function, drug delivery, and host-pathogen interactions. This thesis aimed to characterize electrospun polycaprolactone (e-PCL) in a 96-well plate format as a potential platform for supporting the attachment, proliferation, and differentiation of human airway epithelial cells (Calu-3) u
Atherosclerosis, the formation of inflammatory plaques in the arterial walls, is the most common underlying cause behind cardiovascular disease (CVD). The risk of atherosclerosis has been shown to increase following immune checkpoint inhibitor therapies such as anti-PD1. Anti-PD1 therapy has revolutionized cancer treatment as it blocks the immune checkpoint receptor PD1, preventing T cell exhausti
Deciphering where genes are expressed within the complex architecture of cells and tissues requires advanced spatial transcriptomics techniques. This study focuses on Multiplexed Error-Robust Fluorescence In Situ Hybridization (MERFISH), a technique for spatial transcriptomic. The MERFISH experiment involves probes binding to specific RNA-targeted sequences within fixed cells and tissues. I develo
GPS tracking technologies are essential to follow long-distance migratory species throughout their annual cycle and identify the threats they encounter at large geographical scales. Information on the “lost” years of juvenile individuals of many species is lacking and it is vital to uncover their movements during these critical early stages. The Baltic Lesser Black-backed Gull (L. f. fuscus), a lo
Sex-based differences in immune responses are a well-established phenomenon, with males generally displaying stronger innate immunity and females exhibiting enhanced adaptive responses. The androgen receptor (AR) is the main effector of androgen-induced changes in the body through genomic transcription and has been implicated as one of the origins of sex-based differences in immunity. This thesis
Landskronas öppna verkstad undersöker hur ett mindre tillägg i en urban kontext kan bidra till en ökad aktivering av närområdet och samtidigt ge utrymme för ökad rörelse från resten av staden. Projektet tar sin utgångspunkt i ambitionen att skapa ett genomarbetat förslag som förhåller sig till de funktionella krav som ställs, samtidigt som det är starkt förankrat i sin kontext. Projektet prövar id
Papain-like protease (PLpro) of SARS-CoV-2 is a vital enzyme involved in viral polyprotein processing and in the suppression of host immune response. Due to its strategic role in viral replication and pathogenesis, PLpro represents a valid yet challenging target for drug development. Fragment-based drug discovery (FBDD) is a powerful strategy employed by the FragMAX facility at MAX IV to identify
Alzheimer's disease (AD) is a neurodegenerative disease that often occurs in the elderly and is often accompanied by cognitive loss. Its main pathological features are the formation of amyloid-beta (Aβ) plaques and Tau tangles in the brain. Here, we used single-cell RNA sequencing (scRNA-seq) combined with computational cell–cell communication (CCC) analysis to systematically investigate trans
Consistent behavioural differences among individuals can have significant ecological and evolutionary consequences, yet their origins and persistence within populations have proven challenging to determine. In newly established populations at expanding range margins, behavioural variation may result from natural selection and spatial sorting, with behavioural types that promote dispersal being mor
Sexually reproducing species tend to have reproductive barriers between them that prevent hybrid offspring from being formed. Drosophila melanogaster and D. simulans are two closely related species that can form sterile hybrids. In addition to their post-zygotic barriers, which cause the hybrid sterility, some behavioral pre-zygotic barriers also exist. These include different preferences for cour
When cultivating barley (Hordeum vulgare), access to cultivars with shorter flowering time can be helpful in various agricultural settings, such as the effort of expanding agricultural capabilities into colder regions with shorter growing seasons. The recently identified gene Praematurum-b (Mat-b) is known to cause the plants to flower 7 days early on average. This thesis aimed to analyze the effe
Due to human-induced environmental changes, many natural populations are undergoing extensive fitness declines. Natural or sexual selection could potentially shift the phenotypic mean of critical traits towards new phenotypic optima, promoting evolutionary rescue. However, this process has rarely been studied in natural populations. Furthermore, the population fitness can also be increased by gene
The extensive use of pesticides within the agricultural landscape is essential for maintaining sufficient yields and sustaining our growing population, however, their widespread use is not without costs. Increasing evidence shows that pesticides harm many non-target organisms, including those providing vital ecosystem services. Pollinators, for instance, are critical for the fruiting of nearly 75%
