Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a profound impact on clinical outcomes in cancer patients. At decreased oxygen tensions, hypoxia-inducible factors (HIFs) 1 and 2 are stabilized and mediate a hypoxic response, primarily by acting as transcription factors. HIFs exert differential effects on tumor growth and affect important cancer hallmarks in

OBJECTIVES: The aim of this study was twofold: (i) to evaluate the air levels of N-nitrosamines in the Swedish rubber industry and (ii) to estimate the risk of symptoms and changed levels of immunologic markers in relation to these levels.METHODS: Using adsorption tubes, we collected samples of N-nitrosamines in the breathing zone of 96 rubber workers and analyzed them with liquid chromatography t

A century after its inception, agroecology has entered mainstream development debates as a more sustainable alternative to conventional agricultural modernization of relevance not least for improving smallholder agriculture in sub-Saharan Africa. Agroecology is a broad concept considered to have transformative potential, yet as a research field it has often been technology-centred and focused at t

This contribution analyses the presence of Economic History in the undergraduate study programmes of some European countries. The objective is to offer a counterpoint to the Spanish experience, which will be addressed by other papers and is also likely the most known framework for most of the participants. We look at the total offer of Economic History courses, as well as at whether they are only

Aims and objectives: To investigate lung recipients' process of transition from prior the transplantation to one year afterwards, as well as what their main concerns are and how they deal with these concerns. Background: During the last three decades, lung transplantation has been established as an effective treatment for patients with end-stage pulmonary disease. Towards the end of the 20th centu

Protein biomarkers have the potential to improve diagnosis, stratification of patients into treatment cohorts, follow disease progression and treatment response. One distinct group of potential biomarkers comprises proteins which have been linked to cancer, known as cancer associated proteins (CAPs). We determined the normal variation of 86 CAPs in 72 individual plasma samples collected from ten i

Aim: This study evaluated the musculoskeletal effects of increased physical activity on children, starting at six to nine years of age. Methods: In one school we increased the physical education of 72 girls and 100 boys to 200 minutes per week over seven years. In three other schools, 45 girls and 47 boys continued to receive 60 minutes per week. We measured areal bone mineral density (aBMD) with

Hypoxia promotes tumour aggressiveness and resistance of cancers to oncological treatment. The identification of cancer cell internalizing antigens for drug targeting to the hypoxic tumour niche remains a challenge of high clinical relevance. Here we show that hypoxia down-regulates the surface proteome at the global level and, more specifically, membrane proteome internalization. We find that hyp

Objective Overproduction of cell-free fetal hemoglobin (HbF) in the preeclamptic placenta has been recently implicated as a new etiological factor of preeclampsia. In this study, maternal serum levels of HbF and the endogenous hemoglobin/heme scavenging systems were evaluated as predictive biomarkers for preeclampsia in combination with uterine artery Doppler ultrasound. Study design Case-control

Pseudomonas aeruginosa is an opportunistic pathogen known for its immune evasive abilities amongst others by degradation of a large variety of host proteins. Here we show that digestion of thrombin by P. aeruginosa elastase leads to the release of the C-terminal thrombin-derived peptide FYT21, which inhibits pro-inflammatory responses to several pathogen-associated molecular patterns in vitro and

Background Ischemic injury of an organ causes metabolic change from aerobic to anaerobic metabolism. It has been shown in experimental studies on the heart and liver that such conversion may be detected by conventional microdialysis probes placed intra-parenchymatously, as well as on organ surfaces, by assaying lactate, pyruvate, glucose, and glycerol in dialysate. We developed a microdialysis pro

Background Although associated with severe clinical complications, phosphate remains a neglected ion. Additionally, phosphate balance during continuous renal replacement therapy (CRRT) is complex and multifunctional. The present retrospective study investigated the effects of phosphate-containing CRRT fluid on phosphate homeostasis. Methods We retrospectively analysed 112 patients treated with CRR

Objectives: Individuals with Parkinson's disease (PD) become unavailable in the workforce earlier than comparable members of the general population. This may result in significant social insurance expenses, but as workforce participation can be a source for social interaction and a vital part of the personal identity, there are likely to be personal implications extending far beyond the economic a

This contribution presents complimentary mineralogical and whole-rock chemical data for the Mullnäset rapakivi massif. Three rock types occur: gabbro, syenite with associated granite and “normal” rapakivi granite, here denoted rapakivi-textured granite. In the syenite-associated granite, extremely Mg-poor clinopyroxene and fayalite are the most important mafic minerals, whereas ferrohornblende and

This article is an in-depth comparative case study of six leadingmanufacturing firms in the Great Zurich region of Switzerland and the Sichuanprovince of China. It employs innovation system approach, institutionalthickness framework and social network analysis to investigate the regionalinstitutions of the two regions and their impact on the connectedness of the casefirms’ internal and external in

The pace at which the world's ecosystems and biodiversity of, e.g., pollinators decline is currently at a rate where it is challenging to document. In recent years, our group has made an effort to bridge the disciplines of laser remote sensing and biophotonics, and we have developed lidar methods for inventorying the biosphere. Here, we present an effective method for extracting fauna observations