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Biomarker Discovery in Cancer using Affinity Proteomics - Studies of B-cell lymphomas and Breast Cancer

Popular Abstract in Swedish Antalet människor som insjuknar i cancer (cancerincidensen) runtom i världen ökar, exempelvis i Sverige har antalet diagnosticerade tumörer ökat med i snitt 2.1% per år de senaste 20 åren. Denna ökning förklaras bland annat av vår ökade livslängd och vårt val av livsstil. Trots detta har antalet människor som dör i cancer minskat de senaste 20 åren. Dessa motsägelsefullThe continual increase in incidence of cancer has created an urgent need for improved methods for diagnosis, prognosis and/or treatment. In this context, the field of biomarker research has expanded immensely during the last few years. This thesis, based on four original papers, revolves around protein biomarker discovery in cancer. For this purpose, an in-house design recombinant antibody microar

Modeling and Analysis Approaches for PEMFCs

Proton exchange membrane fuel cells (PEMFCs) are expected to play a significant role in the next generation of energy systems and road vehicles for transportation. To achieve high performance, low cost and high reliability, significant attention is needed on detailed modeling and simulation of various physical processes in PEMFC unit-cells. Substantial effort is also required to reach proper water

Contributions to the generation of semantic editors

The state-of-the-art in development tools today provides users with a large number of both syntactic and semantic services, such as syntax highlighting, name completions and refactorings. Preferably, every language should have sophisticated tool support, but unfortunately, the manual task of tool development is both time-consuming and error-prone, making it too costly for small language communitie

The cloning of a rapidly evolving seminal-vesicle-transcribed gene encoding the major clot-forming protein of mouse semen

Approximately 30 kb of the mouse genome, containing the gene for a major seminal vesicle transcript, has been cloned. The gene was identified by the similarity to members of a family with rapidly evolving genes that includes the gene encoding the major clot protein in rat semen, SVS II, and the human semenogelin genes. The nucleotide sequence of 16.9 kb was determined; this sequence encompasses th