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Background: Wrist osteoarthritis (OA) is mainly posttraumatic, affects younger individuals than other types of OA, and can lead to significant disability. The first-line treatment is patient education and exercise, but surgery may be considered if symptoms persist. A mini-invasive surgical approach for wrist OA is partial wrist denervation, which,in theory, alleviates pain by resecting sensory ner

In pancreatic ductal adenocarcinoma (PDAC), the dense desmoplastic stroma and insufficient infiltrating T cells represent a significant barrier to effective immunotherapy. In this phase I, dose-escalation study, previously registered at the Dutch Trial Register and later on at ClinicalTrial (NCT05650918), we administer an autologous dendritic cell (DC) vaccine (MesoPher) with an agonistic CD40-spe

Natural history collections hold immense global significance – not only as historical archives but also as precious resources for novel scientific discoveries. These collections, housed in museums and institutions worldwide, are (or should be) accessible and open for study. In this paper, we provide a brief history of the fossil collections at Lund University, Sweden, tracing their origins, key hi

For the development of a joint European capacity for monitoring CO2 emissions, we created the framework “CO2 Monitoring Challenges City Mapbooks v1.0” (CMC-CITYMAP). It includes a Jupyter notebook tool (Storm et al., 2025a, https://doi.org/10.18160/P8SV-B99F) which we use to characterise and cluster cities based on aspects relevant for different CO2 monitoring challenges. These include:a. determin

We explore the decay of free neutrons into exotic long-lived particles, whose decays could be detected in the next-generation free neutron experiments. We show that such a possibility is viable as long as the exotic particle is highly mass-degenerate with the neutron, avoiding exclusion by large-volume detectors. We estimate the number of observable events and identify the most promising final sta

BACKGROUND: Monitoring of vital signs is essential in anaesthesia care and plays a key role in preventing adverse events. Technological innovation is recognised as an important factor in enhancing patient safety. Smart glasses represent a novel tool that may support anaesthesia professionals in monitoring vital signs; however, their practical use and user experiences in anaesthesia care remain ins

This study aimed to test and validate a dual-time-window (DTW) protocol for 6-(fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]MK6240) dynamic PET imaging in experimental datasets acquired in human subjects. Methods: DTW protocols were tested and validated in datasets previously collected in 25 participants: 13 were cognitively normal, 10 had mild cognitive impairment, and 2

OBJECTIVES: Opioid-free anesthesia (OFA) is a promising alternative to traditional opioid-based anesthesia. Research indicates that OFA reduces postoperative opioid consumption and related adverse effects while maintaining effective pain control and patient safety. Despite these benefits, clinical adoption of OFA remains limited, possible due to gaps in evidence. To bridge this knowledge gap, a we

This thesis explores the spatial distribution of trees in the LPJ-GUESS dynamic global vegetation model and proposes some modification to improve ecological realism. In the standard version of LPJ-GUESS, the model simplifies forest dynamics by averaging individuals into cohorts and disregarding competition, canopy interactions or resource allocation completely. To improve this, a newer version was

We measured πΣ invariant mass spectra below and above the K̄N mass threshold in the K-d → NπΣ reaction in order to study the K̄N interaction and the Λ(1405) resonance. This reaction can be described by the two-step process: (i) K-N1 → K̄N followed by (ii) K̄N2 → πΣ, where N1 and N2 are nucleons bound in the deuteron. We deduced the S -wave scattering amplitude of K̄N → K̄N as well as K̄N → πΣ in I

Objectives: Many Japanese adults experience poor sleep quality. Prolonged sedentary behavior negatively affects health, including sleep-associated problems. We investigated the association between sedentary behavior and sleep quality among urban white-collar workers in Japan with metabolic syndrome or at risk of metabolic syndrome, a population thought to have particularly prolonged sedentary time

This paper sets out to discuss the relevance of the concept of the ”social help state” (socialhjälpstaten) within the framework of Swedish historiography by focusing on the organization of poor relief in Gothenburg between 1890 and 1920. Coined by Norwegian historian Anne Lise Seip in 1984, the term socialhjälpstaten has been used extensively in the study of early welfare institutions and provisio

Syftet med detta arbete är att undersöka om rullande bärighetsmätningar RWD är ett alternativ till fallviktsmätningar FWD i arbetet kring vägbärighet i vägprojekt. Bärighet beskrivs av Trafikverket som ” Den högsta last, enstaka eller ackumulerad, som kan accepteras med hänsyn till uppkomst av sprickor eller deformationer”. Det vill säga hur tunga fordon en väg eller en bro kan belastas med sThe purpose of this project is to investigate if RWD is an alternative to FWD in analysing road bearing capacity in road projects. According to the Swedish Transport Administration (Trafikverket), the definition of bearing capacity is described as “the maximum load whether single or cumulative, that can be accepted without causing cracking or deformation”. In other words, it refers to how muc

Till följd av höga växthusgasutsläpp har klimatförändringarnas konsekvenser fastställts av FNs klimatpanel IPCC som ett omfattande hot mot både människans och planetens välbefinnande. För att Parisavtalets mål om att begränsa den globala uppvärmningen till 1,5 grader celcius ska uppnås, krävs snabba och resoluta utsläppsminskningar utan motstycke. Basindustrin, däribland stålindustrin som står förThe emission reductions of the European steel industry which account for 5 of CO2 emissions within the European Union (EU), have thus far been limited in part due to the free allocation under the Emissions Trading System (ETS). Legislation has been introduced, aimed at increasing the effectiveness of the ETS by phasing out the free allocation while simultaneously protecting the European steel indu

The production yields of antideuterons and antiprotons are measured in pp collisions at a center-of-mass energy of s=13 TeV, as a function of transverse momentum (pT) and rapidity (y), for the first time rapidity-differentially up to |y|=0.7. The measured spectra are used to study the pT and rapidity dependence of the coalescence parameter B2, which quantifies the coalescence probability of antide

Clusters of galaxies are the largest gravitationally-bound structures in the Universe. They are composed of galaxies and gas (approximately 15% of the total mass) mostly dark matter (DM, accounts up to 85% of the total mass). If the DM is composed of Weakly Interacting Massive Particles (WIMPs), galaxy clusters represent one of the best targets to search for gamma-ray signals induced by the decay

In situ geologic context mapping based on rover and helicopter observations provides documentation of a nearly continuous record of geology and exposed surface structure over a 120 m-wide corridor along the traverse of the Mars 2020/Perseverance rover. The results record the geologic context of Mars 2020 campaign sites and sample sites, including the local extent of bedrock outcrops, stratigraphy,

The first measurement of HΛ3 and H‾Λ‾3 differential production with respect to transverse momentum and centrality in Pb–Pb collisions at sNN=5.02 TeV is presented. The HΛ3 has been reconstructed via its two-charged-body decay channel, i.e., HΛ3→3He+π−. A Blast-Wave model fit of the pT-differential spectra of all nuclear species measured by the ALICE collaboration suggests that the HΛ3 kinetic free

Inclusive cross-sections for top-quark pair production in association with charm quarks are measured with proton–proton collision data at a center-of-mass energy of 13 TeV corresponding to an integrated luminosity of 140 fb−1, collected with the ATLAS experiment at the LHC between 2015 and 2018. The measurements are performed by requiring one or two charged leptons (electrons and muons), two b-tag

Viruses that infect single-celled algae strongly regulate microalgae growth and community composition through cell lysis, enable nutrient recycling in marine ecosystems, and offer valuable insights into early stages of viral evolution. One major group, the Bacilladnaviridae family of single-stranded DNA viruses, infects diatoms in marine environments. Here, we present the capsid structure of Ch