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Biological mechanisms of resilience to tau pathology in Alzheimer’s disease
Background: In Alzheimer’s disease (AD), the associations between tau pathology and brain atrophy and cognitive decline are well established, but imperfect. We investigate whether cerebrospinal fluid (CSF) biomarkers of biological processes (vascular, synaptic, and axonal integrity, neuroinflammation, neurotrophic factors) explain the disconnection between tau pathology and brain atrophy (brain re
Organizing employee-driven innovation (EDI) through game-based formats : Understanding participation
The awareness of employee-driven innovation (EDI) and its strategic relevance to corporate development has recently increased. The implications of EDI are vigorously discussed in terms of inclusive approaches; particularly focussing on how managerial structures can enable employee participation. This paper focusses on game-based formats to enhance such participation and explores what participation
Refugee bonds: social impact investment and implications for international protection
New connections of medication use and polypharmacy with the gut microbiota composition and functional potential in a large population
Medication can affect the gut microbiota composition and function. The aim of this study was to investigate connections between use of common non-antibiotic medicines and the gut microbiota composition and function in a large Swedish cohort (N = 2223). Use of 67 medications and polypharmacy (≥ 5 medications), based on self-reported and prescription registry data, were associated with the relative
Decreasing incidence of celiac disease in Southern Sweden
Background: The incidence of celiac disease (CD) has increased rapidly in the late 20th and early 21st centuries, but there are recent reports of rates levelling off in countries with a high prevalence. The aim of this study was to investigate current trends in CD in southern Sweden. Patients and methods: Children and adults diagnosed with CD by biopsy or serology in the region of Skåne, southern
The interrelationships between renewable energy infrastructure and tourism : A thematic literature review
Increasing demand for renewable energy and rapid tourism growth point to the need for a better overview of the factors affecting the compatibility of renewable energy infrastructure (REI) with tourism. This study aims to systematically review existing research on the interrelationships between REI and tourism, to identify their type and character and the factors affecting them, and to critically d
The Extremely Metal-rich Knot of Stars at the Heart of the Galaxy
We show with Gaia XP spectroscopy that extremely metal-rich (EMR) stars in the Milky Way ([M/H]XP ≳ 0.5) are largely confined to a tight "knot"at the center of the Galaxy. This EMR knot is round in projection, has a fairly abrupt edge near RGC,proj ∼ 1.5 kpc, and is a dynamically hot system. This central knot also contains very metalrich (VMR; +0.2 . [M/H]XP . +0.4) stars. However, in contrast to
The new chronic pain MG30 category and diagnostic specificity in quality registries—problems and suggested solutions with special reference to Swedish Quality Registry for Pain rehabilitation (SQRP)
The Swedish Quality Registry for Pain rehabilitation (SQRP) is a well-established clinical registry for adult patients with complex chronic pain conditions. SQRP registers patient-reported outcome measures from a majority of specialist chronic pain units/departments in Sweden. Up to four International Classification of Diseases version 10 (ICD-10) diagnoses can be registered in SQRP. The aim of th
Quantifying Soil Loss in the Brazilian Savanna Ecosystem : Current Rates and Anticipated Impact of Climate Changes
The Brazilian Savanna (Cerrado) is the second-largest South American biome that corresponds to almost two-third of the national agricultural production. Extensive agricultural-driven land-use changes have significantly altered the landscape, causing increased soil erosion. Furthermore, projections of climate change effects on the Cerrado raise concerns about the potential exacerbation of soil loss
Optimizing Procurement Strategies for Diverse Product Segments : A Case Study in Pharmaceutical Supply Chain Management
Selecting the most suitable procurement strategy is crucial to the efficient management of supply chain operations and the prevention of stock shortages. Nevertheless, when dealing with a wide variety of products, this task becomes an intricate challenge. While traditional and advanced procurement tools are available, applying them across such diverse product ranges is often impractical. This rese
Zircon Microstructures in Large, Deeply Eroded Impact Structures and Terrestrial Seismites
Extraterrestrial cratering was a critical component in the evolution of the early Earth, but discovery of very ancient and deeply exhumed impact structures remains elusive, as identification tools are in short supply. The recognition of such structures is hindered by post-cratering geological processes, whereby impact-induced features common in younger, upper-crustal craters may be lost. In this s
Cooling-Induced Order-Disorder Phase Transition in CsPbBr3 Nanocrystal Superlattices
Perovskite nanocrystal superlattices are being actively studied after reports have emerged on collective excitonic properties at cryogenic temperatures, where energetic disorder is minimized due to the frozen lattice vibrations. However, an important issue related to structural disorder of superlattices at low temperatures has received little attention to date. In this work, it is shown that CsPbB
Measurements of the laminar burning velocities of 1,2-butadiene : A comparative study
1,2-butadiene (1,2-C4H6) is one of four C4H6 isomers that could appear during pyrolysis and oxidation of heavier hydrocarbons and/or contribute to the formation of aromatic species in flames. However, it is seldom included in detailed kinetic mechanisms due to a lack of studies of its combustion characteristics. In this work, laminar burning velocities (LBV) of 1,2-butadiene flames have been measu
Experimental X-ray Diffraction Data for "Cooling-Induced Order-Disorder Phase Transition in CsPbBr3 Nanocrystal Superlattices"
Experimental X-ray diffraction data: -- temperature-dependent diffraction patterns (theta:2theta, rocking curves) for C18 and C8 CsPbBr3 nanocrystal superlattice samples;-- room temperature diffraction patterns (theta:2theta, rocking curves) for C6, C8, C10, C12, and C18 CsPbBr3 nanocrystal superlattices;in all files, first column is angle in degrees and the second column is intensity.
Kontanternas värde : Fattigdom och utanförskap i Sveriges digitala ekonomi
Användningen av kontanta pengar minskar och allt fler betalningar görs digitalt. Detta är en global förändring, men den är ovanligt tydlig just i Sverige. Det blir allt vanligare att kollektivtrafiken, affärer och andra serviceställen inte tar emot kontanter som betalningsmedel. Möjligheten att betala räkningar med kontanter över disk är högst begränsad; i stora delar av Sverige finns den inte all
Kullabygdens berggrund
En berättelse om att kombinera immunoterapi med ultrahypo-fraktionerad strålterapi
Sammanfattning:Denna berättelse om immunoterapi kombinerad med ultrahypo-fraktionerad strålterapi har sitt ursprung i den kliniska studie som på engelska benämdes "Brain Immune Gene Tumour Therapy" (BRIGTT) som professor Leif G, Salford i Lund initierade strax innan 2000-millienium-skiftet. Ett specifikt tumörvaccin framställdes baserat på tumörceller som han extraherade ur tumörvävnad från den gl
Structure and dynamics in dense ionic fluids : general discussion
Low Resistivity n‐type GaN Ohmic Contacts on GaN Substrates
In this study, a report is prepared on significantly low specific contact resistivity of alloyed and non-alloyed ohmic contacts fabricated on an as-grown n+-GaN layer and measured with the transfer length method. A low ρc = 8 × 10−8 Ω cm2 is extracted for the alloyed Ti/Al/Ni/Au, and ρc = 4 × 10−7 Ω cm2 for the unannealed Ti/Pd/Au. To achieve these, a highly doped n+-GaN layer with ND = 1.5 × 1019
