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Anticoagulation in patients at high risk of stroke without documented atrial fibrillation. Time for a paradigm shift?

Atrial fibrillation (AF) is currently considered a risk factor for stroke. Depending on the severity of clinical factors (risk scores) a recommendation for full anticoagulation is made. Although AF is most certainly a risk factor for ischemic stroke, it is not necessarily the direct cause of it. The causality of association between AF and ischemic stroke is questioned by the reported lack of tempo

Multi-MHz time-of-flight electronic bandstructure imaging of graphene on Ir(111)

In the quest for detailed spectroscopic insight into the electronic structure at solid surfaces in a large momentum range, we have developed an advanced experimental approach. It combines the 3D detection scheme of a time-of-flight momentum microscope with an optimized filling pattern of the BESSY II storage ring. Here, comprehensive data sets covering the full surface Brillouin zone have been use

The Long-term Durability of Intra-operatively Placed Palmaz Stents for the Treatment of Type Ia Endoleaks After EVAR of Abdominal Aortic Aneurysm

Objective/Background The objective was to analyze the long-term durability of intra-operatively placed Palmaz stents for type Ia endoleaks, and the evolution of aneurysm neck morphology. Methods This was a retrospective cohort study conducted at a tertiary referral centre. Patients treated between 1998 and 2012 were reviewed with regard to pre-, intra-, and post-operative data. Crude and relative

Meniscus morphology : Does tear type matter? A narrative review with focus on relevance for osteoarthritis research

Objective: To give a narrative overview of meniscal tears with a radiologic emphasis on the morphologic type, technical considerations, and on the relevance of the type of meniscal tear in the context of osteoarthritis (OA) research. Design: Total 20 years of the PubMed database were searched for epidemiological, radiological, arthroscopic and biomechanical reports, and review articles focusing on

Release of PACAP-38 in episodic cluster headache patients - An exploratory study

Background: Activation of the trigeminal-autonomic reflex, involving the trigeminal ganglion, the superior salivatory nucleus and the sphenopalatine ganglion (SPG) is crucial in the pathophysiology of cluster headache (CH). Since pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) is present both in the SPG and the trigeminal ganglion (TG) and its role in migraine has been described,

ECG-derived spatial QRS-T angle is strongly associated with hypertrophic cardiomyopathy

Introduction: ECG-derived vectorcardiography (VCG) has diagnostic and prognostic value in various diseases. Hypertrophic cardiomyopathy (HCM), a genetic disease with unexplained left ventricular hypertrophy, is one of the most common causes of sudden cardiac death (SCD) in young persons. Genotype positive status is associated with increased risk of systolic dysfunction, heart failure, and (SCD). H

The epidemic of methylisothiazolinone : A European prospective study

Background: The use of methylisothiazolinone (MI) in cosmetic products has caused an unprecedented epidemic of MI contact allergy. Current data concerning exposures at a European level are required. Objectives: To describe demographics and MI exposures for European patients with MI contact allergy. Methods: Eleven European dermatology departments from eight European countries prospectively collect

Esophageal and gastric dysmotilities are associated with altered glucose homeostasis and plasma levels of incretins and leptin

BACKGROUND: Gastrointestinal complications in diabetes may affect glucose and endocrine homeostasis. Glucosedependent insulinotropic peptide (GIP), glucagon-like peptide-1 (GLP-1), and leptin regulate glucose homeostasis, food intake, and gastric emptying. AIM: The aim was to investigate associations between diabetes complications and glucose homeostasis and plasma levels of GIP, GLP-1, and leptin

Environmental Integration in Competition and Free-Movement Laws

Environmental Integration in Competition and Free-Movement Laws engages in a comprehensive analysis of the obligation of Article 11 TFEU (integration of environmental protection requirements) in the three core areas of EU internal market law: competition, state aid, and free movement. It develops a theoretical framework for integrating environmental and other policies and compares how environmenta

Liposuction of lymphedema of the extremities

Lymphedema is the accumulation of lymph fluid in the interstice with secondary tissue changes. The accumulated lymph stimulates adipose tissue deposition, and a marked adipose tissue hypertrophy can be seen in patients with chronic lymphedema. The basis for all lymphedema treatment is adequate compression therapy. However, if the lymphedema has started to transform into adipose tissue, conservativ

UBER between Labour and Competition Law

UBER is often described as disruptive innovator. This paper examines whether the UBER model disrupts the classical competition analysis thereby creating the uber-cartel, a cartel to which the normal competition rules don’t apply. This working paper on UBER and UBER-like business models examines issues that such a model faces with regard to labour and competition law with a particular focuses on th

Quality of life in patients with Dercum’s disease : Before and after liposuction

Dercum’s disease is a rare disease characterized by chronic pain (>3 months) in the adipose tissue, generalized overweight, and a number of associated symptoms. The pain is often disabling and resistant to traditional analgesics. Liposuction of Dercum’s disease was first described in 1987, and two prospective controlled studies have demonstrated that it can give pain relief and improve quality of

Journal of Antitrust Enforcement Agency Effectiveness Study

The Agency Effectiveness Study explores a wide range of the daily concerns faced by competition agency heads and their staff, with an emphasis on the formal and informal ways in which they are addressed. Managing and operating a competition agency is very much a process of learning-by-doing. The aim of the study is, therefore, to capture and make available the know-how that competition agency offi

Analysis of 210Pb in water samples with plastic scintillation resins

210Pb is a radioactive lead isotope present in the environment as member of the 238U decay chain. Since it is a relatively long-lived radionuclide (T1/2 = 22.2 years), its analysis is of interest in radiation protection and the geochronology of sediments and artwork. Here, we present a method for analysing 210Pb using plastic scintillation resins (PSresins) packaged in solid-phase extraction colu