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This paper argues that we have a moral obligation to implement certain health technologies even if we have limited or incomplete evidence of their effectiveness. The focus is on technologies used in non-emergency settings, as opposed to “exceptional cases” such as compassionate use and emergency approvals during public health emergencies. A broadly plausible moral principle – the Ecumenical Princi
Background: Although lipoprotein(a) (Lp[a]) has been associated with acute myocardial infarction (MI), the relationship between Lp(a) and the presence of high-risk “vulnerable” coronary plaques has not been studied. Objectives: The aim of this study was to investigate whether specific lipoproteins are associated with pancoronary plaque volume and lipid deposition vs the development of non-flow-lim
Systemic vasculitis, common forms of which include anti-neutrophil cytoplasmic antibody-associated small-vessel vasculitis, large-vessel vasculitis and Behçet syndrome, are frequently complicated by arterial or venous thrombotic events (AVTEs). Newly identified entities such as DADA2 (deficiency of adenosine deaminase 2) and VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome
Airborne wear particle emissions from dry clutches have been investigated in terms of particle mass and number concentration, size distribution, and chemical composition of a single clutch material. This paper presents a detailed continuation of the investigation. Clutch plates of two different friction materials, i.e., from different manufacturers but for the same automobile applications, are tes
Sepsis is a life-threatening condition caused by a dysregulated host response to an infection and is a leading cause of death worldwide. The condition is variable, which in combination with insufficient clinical markers, makes it challenging to predict when infection will progress to sepsis and to categorize patients into homogeneous patient subgroups. In this study, we demonstrate the use of acou
This study proposes a novel devolatilization model based on a convolutional neural network (CNN), employing quantified coal chemical structure features as input. Initially, a reliable method was developed to quantify the average/heterogeneous properties of coal structures using high-resolution micro-Raman spectroscopy. The evolution of chemical structure with increasing coal rank was investigated
We are interested in studying sets of the form U ( α ) := { x ∈ X : ∃ M = M ( x ) ⩾ 1 such that ∀ N ⩾ M , ∃ 1 ⩽ n ⩽ N such that d ( T n x , x ) ⩽ | λ | − α N } , where ( X , T , d ) is our metric dynamical system and | λ | > 1 . Although many results exist for the one dimensional case, not as many are known for systems in higher dimensions and especially in the hyperbolic case. We consider X = T 2
Background and purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by progressively destructive polyarthritis. Key autoimmune features include the presence of autoantibodies. The purpose of this review is to discuss the diagnostic and prognostic properties of rheumatoid factor (RF) and anti-citrullinated protein/peptide antibodies (ACPA), based on current use in Swe
This paper critiques the implementation of the EU's Smart Specialization Strategies (S3), advocating for a deeper analysis of the long-term evolution of regional industrial portfolios. We investigate the changing coherence of these portfolios across 401 German NUTS-3 regions from 1993 to 2018, utilizing skill- and task-based metrics for relatedness and complexity, alongside sequence analysis and o
Understanding to what extent phenotypes vary in their physiological traits and their associations to life-history strategies may help to better understand how animals are adapted to their environment and how they can cope with changing conditions. Melanin-based colour polymorphism is a phenotypic trait closely associated with physiological characteristics and fitness, which in tawny owls (Strix al
This paper reports results from a trust game in which trustors, before deciding on their transfer, are shown a statement about the perception of the situation by another person. Statements expressed either suspicion, insecurity, worry of disappointment or curiosity. Trustors first had to indicate their identification with the statement before making trust game decisions. Compared to a standard tru
We have investigated the bacterial decomposition of dissolved organic matter (DOM) extracted from the organic layer of a boreal forest soil and filtered at a pore size of 0.2 µm. This DOM source has previously been extensively characterized and contains approximately equal amounts by carbon of a colloidal fraction, mainly composed of carbohydrates, and a fraction of molecularly dissolved DOM. Here
Private-sphere conversations about global environmental change play an important role in environmental communication. However, they receive less attention than information campaigns aimed at raising awareness, educating, or challenging the public. From a psychological perspective, it is increasingly recommended to talk about global environmental change and the emotions it evokes as a way of coping
