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Purpose: Agriculture innovation systems (AIS) examine the complex socio-technical and institutional aspects affecting sustainable agriculture. However, it is predominantly constrained to the formal sector activities in the high-income countries (HICs). The informal sector actors play a major role in the agricultural sector of low- and middle-income countries (LMICs), such as India, by innovating a

The advances in understanding and producing heavy and super-heavy elements is the subject of this topical collection. The main covered subjects are: the description of the theory, developments of super-heavies and the determination of the Island of Stability as well as the role of these nuclei as part of the r-process scenario. The accurate determination of reaction processes are crucial to enable

To a large degree, economic metrics and mechanisms underpin the design of adaptation policies. Such a focus has undesired consequences on the effectiveness of adaptation measures as well as on our ability to prevent incommensurable losses. The article puts forward four strategic changes in adaptation policy that shift the focus away from markets and toward community-level visions of what a liveabl

The main objective of this study was to evaluate heavy metal contamination in volcanic and calcareous soils within Morocco’s semi-arid regions, focusing on the relationship between unique soil types and contamination dynamics. Using geographic information systems (GIS), statistical analyses, and several pollution indices, including the geoaccumulation index (Igeo), enrichment factor (EF), contamin

Moisture damages lead to significant costs and impact indoor environments negatively. Identifying their occurrence patterns is crucial for the implementation of preventive or mitigative measures, though it remains highly challenging due to the complex interplay of multidimensional variables. This study aims to identify primary moisture damage profiles in Swedish buildings and evaluate their preval

Background: High-grade glioma (HGG) of the spinal cord constitutes rare tumors in the pediatric population. Knowledge of the molecular profile of this pediatric HGG (pedHGG) subgroup is limited and the clinical outcome is poor. Therefore, the aim of this study is to provide more profound investigations of molecular characteristics and clinical features of these tumors. Methods: Between January 201

Background: The application of international recommendations for paediatric maintenance haemodialysis (HD) could be strengthened by national laws or written recommendations. Our aim was therefore to describe the national rules governing paediatric maintenance HD in European countries. Methods: A national representative, approved by the president of each paediatric nephrology society, was contacted

Predictors for the pharmacological effect of ADHD medication in children and adolescents are lacking. This study examined clinically relevant factors in a large (N = 638) prospective cohort reflecting real-world evidence. Children and adolescents aged 6–17 diagnosed with ADHD were evaluated at baseline and three months following ADHD medication initiation. The outcome was measured as a reduction i

Among different lipid nanoparticle systems, sponge-phase nanoparticles (SPNPs) have recently attracted interest due to their ability to encapsulate large macromolecules along with demonstrated high interfacial activity. The potential application of SPNPs calls for investigations into how buffer conditions affect SPNP structure and interfacial activity. Herein, we systematically investigated how di

Interpretation of data from faint dwarf galaxies is made challenging by observations limited to only the brightest stars. We present a major improvement to tackle this challenge by undertaking zoomed cosmological simulations that resolve the evolution of all individual stars more massive than 0.5 M⊙, thereby explicitly tracking all observable stars for the Hubble time. For the first time, we predi

Background: Community-acquired pneumonia (CAP) was one of the most common causes of death in the European Union in 2017. Severity and mortality of CAP increase with age and an aging European population will require increased planning for prevention, control, and management of CAP. The purpose of this study was to provide an updated population-based estimate of the incidence of CAP requiring hospit

Background: Adverse pregnancy outcomes, such as preterm delivery and hypertensive disorders of pregnancy, may be associated with higher future risks of heart failure (HF). However, the comparative effects of different adverse pregnancy outcomes on long-term risk of HF, and their potential causality, are unclear. OBJECTIVES: The authors sought to examine 5 major adverse pregnancy outcomes in relati

Background Obsessive-compulsive disorder (OCD) is associated with an increased risk of morbidity and mortality due to cardiometabolic disorders. Whether this association is driven by familial factors is unknown. This population-based family study explored the familial co-aggregation of OCD and cardiometabolic disorders. Methods We identified 6 049 717 individuals born in Sweden between 1950 and 20

Background: The aging of the world’s population and the increase in sedentary lifestyles are leading to an increase in walking impairments at older ages. Here, we aimed to comprehensively discuss walking in the context of an aging population; and identify and agree on a list of future research priorities and policy actions. Methods: We followed a participatory approach and held a multidisciplinary

Policy institutes such as central banks need accurate forecasts of key measures of economic activity to design stabilization policies that reduce the severity of economic fluctuations. Therefore, this paper develops a kernel ridge regression estimator in a mixed data sampling framework. Kernel ridge regression can handle many predictors with a nonlinear relationship to the target variable. Consequ

A novel mechanism of sequestering tumor suppressor mRNAs reveals new therapeutic vulnerabilities in leukemic cells.

In dialogical self theory (DST) authenticity has not been a central concern. The humanist notion of a static, higher-order, superordinate, ultimate, and “true” self runs counter to the ontology of DST, and the conceptualization of the dialogical self as unconsolidated, multifaceted, dynamic, and sensitive to situational change. In a climate in which the psychology of authenticity is undergoing rev