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In the seminal cases C-156/21 and C-157/21 (‘Budget Conditionality Cases’) the Court of Justice of the European Union demonstrated a shift in the perception of the operational functionality of foundational values of the EU, establishing that the rule of law is a founding value of the Union which represents a legal norm and imposes an obligation on the Member States to comply with its constituent e

We discuss remarkable constructions in Icelandic that have the distributive pronoun hvor ‘each’ in common: the reciprocal construction hvor annar ‘each other’, and the distributive construction hvor sinn ‘each their’, which also comes in a sinn hvor ‘their each’ version. We provide the first detailed description of these constructions, in particular their case and word order properties, which rais

For regions that are deeply integrated into the global economy, the question of how to remain competitive and resilient in times of uncertainty is a key concern. While strategic coupling is a useful concept for understanding local-global economic dynamics, the idea that a region can simultaneously couple into multiple production networks organised at different spatial scales and that regional acto

Transparency in artificial intelligence (AI) can mean many things, but at the same time, it is currently a central focus for both scientific and regulatory attention. We seek to critically unpack this conceptual vagueness. This is particularly called for given recent focus on transparency in much of AI policy. To this end, we construct our analysis of AI Transparency into four facets. Firstly, (1)

Diffusion MRI (dMRI) sensitizes the MR signal to the diffusion of water molecules at the microscopic level and thereby non-invasively probes tissue microstructure. This is relevant when determining biological properties of tissues, for example, cancer type and its malignancy. The problem is, however, that dMRI lacks sensitivity and specificity to distinct microstructural features because an image

Non-medical prescription use of opioids (NMPUO) is a public health concern worldwide. Recently, tramadol misuse is increasing, but the systematic research of misuse of this specific opioid is limited. This study set out to assess the relationship between tramadol use and completion of treatment for substance use among adolescents and adults ≤ 25 years in an outpatient clinical setting. A retrospec

Patients with mental illness have an increased risk of cardiovascular morbidity. The Swedish-developed Health Dialogue is a pedagogical tool to individualize lifestyle counselling, used in specific age-groups to improve lifestyle habits and decrease mortality, but not tested specifically for patients with mental illness. Patients > 18 years old seeking primary care due to symptoms related to menta

In this work, we demonstrate an effective anion capturing in an aqueous medium using a highly porous carbon paper decorated with ZnO nanorods. A sol–gel technique was first employed to form a thin and compact seed layer of ZnO nanoparticles on the dense network of carbon fibers in the carbon paper. Subsequently, ZnO nanorods were successfully grown on the pre-seeded carbon papers using inexpensive

Chaperones play a central part in the quality control system in cells by clearing misfolded and aggregated proteins. The chaperone DnaK acts as a sensor for molecular stress by recognising short hydrophobic stretches of misfolded proteins. As the level of unfolded protein is a function of protein stability, we hypothesised that the level of DnaK response upon overexpression of recombinant proteins

Advancement in nanotechnology to a large extent depends on the ability to manipulate materials at the atomistic level, including positioning single atoms on the active sites of the surfaces of interest, promoting strong chemical bonding. Here, we report a long-time confinement of a single Ag atom inside a corner hole (CH) of the technologically relevant Si(111)-7×7 surface, which has comparable si

Objective: The aim is to describe and reflect upon potentially pandemic-related impact on self-assessments of active ageing. As part of the baseline data collection in the Prospective RELOC-AGE (ClinicalTrials.gov NCT04765696) study, telephone interviews, including the University of Jyvaskyla Active Aging Scale (UJACAS) were conducted with 820 people 55 years or older listed with an interest of re

This paper studies to what extent religion has been used to legitimize political power throughout the world and how this matters for current institutions.Historically, some rulers have used religion to legitimize their power, while others relied on more democratic means. This tendency, termed divine legitimization, incentivized rulers to embed religion into institutions. We illustrate within a sim

This book explores the role of agriculture in long-term economic growth. With a particular focus on Ethiopia, the role of the state in igniting agricultural growth and in sustaining economic growth is highlighted as essential for low-income countries. Taking ideas from both economic history and development economics, the ability of Ethiopia and the rest of Africa to sustain recent rapid growth intThe twenty-frst century has seen the concurrent rise of optimism about economic growth in sub-Saharan Africa and the return of the agricultural sector to the top of the development agenda. Ethiopia—with its rapid economic growth for two decades, achieved during a policy focus on the agricultural sector—is at the forefront of both these developments. This chapter introduces the book’s main theme of

Overvoltage is becoming increasingly prevalent in distribution networks with high penetration of renewable distributed energy sources (DERs). Local control of converter-based resources is a flexible and scalable method to prevent this growing issue. Reactive power is used for voltage control in many local control schemes. However, the typical range of R/X ratios for distribution power lines indica

Galectin-3 is a β-galactoside-specific, carbohydrate-recognizing protein (lectin) that is strongly implicated in cancer development, metastasis, and drug resistance. Galectin-3 promotes migration and ability to withstand drug treatment of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells. Due to high amino acid conservation among galectins and the shallow nature of their glycan-binding

Background: Surgical extraction of testicular spermatozoa is needed in men with nonobstructive azoospermia (NOA) who wish to become biological fathers. Based on available uncontrolled studies with unspecific patient selection, microdissection testicular sperm extraction (mTESE), having a sperm retrieval rate (SRR) of 50%, is considered the most efficient sperm retrieval procedure. However, no rand

Objective: The effect of cardiac arrest (CA) on cerebral transcriptomics and metabolomics is unknown. We previously demonstrated hemodynamic-directed CPR (HD-CPR) improves survival with favorable neurologic outcomes versus standard CPR (Std-CPR). We hypothesized HD-CPR would preserve the cerebral transcriptome and metabolome compared to Std-CPR. Design: Randomized pre-clinical animal trial. Settin