Type 2 diabetes mellitus (T2DM) is a major disease affecting nearly 280 million people worldwide. Whilst the pathophysiological mechanisms leading to disease are poorly understood, dysfunction of the insulin-producing pancreatic beta-cells is key event for disease development. Monitoring the gene expression profiles of pancreatic beta-cells under several genetic or chemical perturbations has shed

Although numerous genes are known to regulate serum lipid traits, identified variants explain only a small proportion of the expected heritability. We intended to identify further genetic variants associated with lipid phenotypes in a self-contained population of Sorbs in Germany. We performed a genome-wide association study (GWAS) on LDL-cholesterol, HDL-cholesterol (HDL-C), and triglyceride (TG)

Background: Dyscarbia is common in out-of-hospital cardiac arrest (OHCA) patients and its association to neurological outcome is undetermined. Methods: This is an exploratory post-hoc substudy of the Target Temperature Management (TTM) trial, including resuscitated OHCA patients, investigating the association between serial measurements of arterial partial carbon dioxide pressure (PaCO2) and neuro

Background: Older patients with a hip fracture require specialized emergency care and their first healthcare encounter before arriving at the hospital is often with the ambulance service. Since 2005 there has been a registered nurse on the crew of every ambulance in Sweden in order to provide prehospital emergency care and to prepare the patients for hospitalization. It is important to investigate

It has previously been shown in short-term interventions that kernel-based whole grain (WG) rye products have beneficial effects on test markers related to obesity and type 2 diabetes (T2D). T2D increases the risk of several severe health issues, including declined cognitive functions. The protein brain-derived neurotrophic factor (BDNF) is suggested to be a potential biomarker for neuronal integr

Sex differences in parasite load and immune responses are found across a wide range of animals, with females generally having lower parasite loads and stronger immune responses than males. Intrigued by these general patterns, we investigated if there was any sign of sex-specific selection on an essential component of adaptive immunity that is known to affect fitness, the major histocompatibility c

In this paper, we perform a threshold analysis of braided convolutional codes on the additive white Gaussian noise (AWGN) channel. The decoding thresholds are estimated by Monte-Carlo density evolution techniques and compared with approximate thresholds from an erasure channel prediction. The results show that, with spatial coupling, the predicted thresholds are very accurate and quickly approach

De moderna kvinnorna med korta kjolar och ännu kortare hår som jazzade sig igenom 1920-talets nöjesliv är en bild som reproduceras i populärkulturen än idag. Men de moderna kvinnorna sågs i sin samtid inte endast som nöjeslystna kommersiella produkter, utan användes som en arena för att diskutera frågor om nationalitet, rasbiologi, genus, kropp och det moderna samhällets utmaningar. De moderna kvi

Background ST-elevation myocardial infarction (STEMI) occurs as a result of rupture of an atherosclerotic plaque in the coronary arteries. Limited data exist regarding the impact of culprit coronary vessel on hard clinical event rates. This study investigated the impact of culprit vessel on outcomes after primary percutaneous coronary intervention (PCI) of STEMI.Methods A total of 29 832 previousl

The retail industry is looking for new ways to compete as digitalization and non-traditional actors are changing the game. In an industry where constant improvements are key and studies of innovation management are scarce - this qualitative study of four retail firms addresses how innovation is currently perceived and managed. As a result, we have found that innovation is an uncommon theme and the

Most of the literature accumulated around retail change derive a linear, progressive understanding, typically coined with the term “retail evolution”. Once it is formulated as such, a need for adopting a historical perspective to study present becomes superfluous, because the past is understood as something that is left behind, something incapable of making an impact on the present. In this resear

Membrane cleaning is an integrated part of the daily membrane plant operation in the food and biotech industry. However, the impact of membrane cleaning on the plant operations and economics are often neglected parameters in the development of new applications despite the fact that the cost for membrane cleaning is a dominating membrane operating expenditure apart from electricity. The aim of this

Universitet och högskolor är unika myndigheter i Sverige genom att ha en demokratisk styrning med stark representation från verksamheten. I universitetsstyrelsen finns visserligen mer politiskt tillsatta ledamöter och representanter för det omgivande samhället, men bara ett steg längre ned på fakultetsnivå, som vår egen fakultet, är verksamhets- representationen i det närmaste total. V

BACKGROUND: Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and their ratio (Cu/Zn) in relation to hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBD) and gall bladder and biliary tract (GBTC) cancers.METHODS: A nested case-control

The pulp and paper industry is one of the most important industrial sectors worldwide. The focus of current pulp mills is on the production of cellulose pulp fibres and electricity. By converting traditional pulp mills into biorefineries they can be a keystone in a future bioeconomy based on renewable resources instead of fossil fuels. In order to achieve this, pulp mills have to close their loops

Nowadays, the main challenge in designing ultrafiltration membranes is increasing membrane fouling resistance without sacrificing membrane transport properties. Novel method of modification of ultrafiltration membranes using aqueous solutions of commercially available cationic and anionic polyelectrolytes based on acrylamide copolymers is proposed. Polyelectrolytes based on acrylamide copolymers a