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Voltage-gated Ca2+ (CaV) channels trigger glucose-induced insulin secretion in pancreatic beta-cell and their dysfunction increases diabetes risk. These heteromeric complexes include the main subunit alpha1, and the accessory ones, including subunit gamma that remains unexplored. Here, we demonstrate that CaV gamma subunit 4 (CaVγ4) is downregulated in islets from human donors with diabetes, diabe

Metal contamination of water bodies has attracted global attention owing to its environmental toxicity, abundance and persistence. Metals such as arsenic, cadmium and mercury are of greater concern since they are toxic even at low concentrations. Mercury is present at 1000 times lower concentrations than the other two metals, but still has a negative impact on the environment due to its high trans

In this study, we developed a nanoparticle-based mesoporous composite that consisted of silicate-titanate nanotubes (STNTs) supported in hydrogel chitosan beads (STNTs-Ch beads) and was studied for Cd2+ adsorption. By using Fourier-transform infrared spectroscopy, transmission and scanning electron microscopy coupled to an energy-dispersive X-ray spectrometer, we coulddetermine that the hollow STN

Objectives: Depressive symptoms in the elderly have been shown to be associated with increased mortality. The purpose of this study was to examine symptoms of depression in octogenarian men and their association with all-cause mortality, and whether physical, cognitive and social factors influence this association. Methods: Out of the 703 initially included 55-years-old men, from the prospective c

In situ structural and chemical state characterization of Rh/CeO 2 and Ni/CeO 2 catalysts during atmospheric pressure CO 2 methanation has been performed by a combined array of time-resolved analytical techniques including ambient-pressure X-ray photoelectron spectroscopy, high-energy X-ray diffraction and diffuse reflectance infrared Fourier transform spectroscopy. The ceria phase is partiall

The medical landscape is a constantly changing field, both in relation to new knowledge and innovative technology as well as a changing world. Some examples are new emerging diseases and changing welfare societies. In ethnological and folkloric research there is a long tradition of exploring and reflecting upon this kind of issues from a broad variety of methodological and theoretical perspectivesIn this paper I ask how ethnology with a medical humanities perspective can use the term Anthropocene to better understand the emerging fact that we soon will stand without functional antibiotics.

Detta är den åttonde skriften i en serie småskrifter som vi publicerar och som alla handlar vetenskap och beprövad erfarenhet, med fokus på ett eller annat tillämpningsområde. Hittills har vi belyst följande områden: medicin, juridik, skola, miljö, politik och socialtjänst. Detta nummer ägnas åt vård. Våra kartläggningar har lärt oss att begreppet vetenskap och beprövad erfarenhet definieras olika

Numerical simulations and parametric studies of glued-in rods in cross-laminated timber have been performed. The simulations were based on 3D finite element analysis, using a cohesive surface model for the bond-lines between the laminations and the bond-line along the rod. The parametric studies investigated the influence of the glued-in length, the rod diameter, and the rod-to-grain angle on the

Some light beams rotate as they propagate. If it is not the polarization vector, but the phase structure that rotates, the beam is said to carry orbital angular momentum (OAM). Such beams exhibit a helical phase front, where the phase rotates around a symmetry center. Because the phase in the center is undefined (and the intensity there is therefore zero), it is often termed a phase singularity or

This work, framed in the IEA SHC Task 51 “Solar Energy in Urban Planning” presents an illustrative perspective of solar energy in urban planning through the analysis of 34 international case studies conducted in 10 countries. The aim here is to examine challenges, barriers and opportunities for active solar systems and passive solar strategies by taking into consideration interrelated technical an

Quantum field theories containing scalar fields with equal quantum numbers allow for a mixed kinetic term in the Lagrangian. It has been argued that this mixing must be taken into consideration when performing renormalization group (RG) analyses of such a theory. However, from the fact that scalar kinetic mixing does not correspond to a physical observable, we show that no extra parameters need to

The aim is to investigate associations between sexual orientation and experience of suicide thoughts and suicide attempts. The 2012 public health survey in Scania, southern Sweden, is a cross-sectional population-based study including 28,029 participants aged 18–80 with 51.7% participation. The associations between sexual orientation and experience of suicide thoughts and attempts were investigate

In a multicentre European hospital study we measured influenza vaccine effectiveness (IVE) against A(H3N2) in 2016/17. Adjusted IVE was 17% (95% confidence interval (CI): 1 to 31) overall; 25% (95% CI: 2 to 43) among 65-79-year-olds and 13% (95% CI: -15 to 30) among those ≥ 80 years. As the A(H3N2) vaccine component has not changed for 2017/18, physicians and public health experts should be aware

The type of regional innovation system (RIS) strongly affects possibilities of paths of industrial transformation. This paper argues that traditional manufacturing districts, corresponding to specialized RISs and characterized by various nuclei of specialization and know-how, may foster different trajectories in combination with extra-regional networks. In particular, the paper analyses the interp