Serotonin (5-HT), an important modulator of both sensory and motor functions in the mammalian spinal cord, originates mainly in the raphe nuclei of the brainstem. However, following complete transection of the spinal cord, small amounts of 5-HT remain detectable below the lesion. It has been suggested, but not proven, that this residual 5-HT is produced by intraspinal 5-HT neurons. Here, we show b

According to our current cosmological model, galaxies like the Milky Way are expected to experience many mergers over their lifetimes. The most massive of the merging galaxies will be dragged towards the disc plane, depositing stars and dark matter into an accreted disc structure. In this work, we utilize the chemodynamical template developed in Ruchti et al. to hunt for accreted stars. We apply t

Introduction: The diagnosis of acute lung injury (ALI) may be more robust if more accurate physiological markers can be identified. Extravascular lung water (EVLW) is one possible marker, and it has been shown to correlate with respiratory function and mortality in patients with sepsis. Whether EVLW confers diagnostic value in a general population with shock, as well as which index performs best,

An integrated study of palynology, Mossbauer spectroscopy, mineralogy and osmium isotopes has led to the detection of the first K-Pg boundary clay layer in a Southern Hemisphere terrestrial setting. The K-Pg boundary layer was independently identified at centimetre resolution by all the above mentioned methods at the marine K-Pg boundary site of mid-Waipara and the terrestrial site of Compressor C

The aim of this study was to evaluate nerve regeneration in relation to the transcription factor, Activating Transcription Factor 3 (ATF 3), and an apoptotic marker, caspase 3, in the Schwann cells of diabetic BB rats (i.e. display type 1 diabetes phenotype). Sciatic nerves in healthy Wistar rats and in diabetic BB rats were transected and immediately repaired. Axonal outgrowth (neurofilament stai

The cellular hallmarks of Parkinson's disease (PD) are the loss of nigral dopaminergic neurons and the formation of α-synuclein-enriched Lewy bodies and Lewy neurites in the remaining neurons. Based on the topographic distribution of Lewy bodies established after autopsy of brains from PD patients, Braak and coworkers hypothesized that Lewy pathology primes in the enteric nervous system and spread

G-protein-regulated inward-rectifier potassium channel 2 (GIRK2) is reported to be expressed only within certain dopamine neurons of the substantia nigra (SN), although very limited data are available in humans. We examined the localization of GIRK2 in the SN and adjacent ventral tegmental area (VTA) of humans and mice by using either neuromelanin pigment or immunolabeling with tyrosine hydroxylas

Introduction Oesophageal stricture is a frequent complication following repair of oesophageal atresia (EA). The aim of this study was to conduct a pre- and postintervention study and analyze the incidence of stricture formation and need for balloon dilatation after introducing prophylactic proton pump inhibitor (PPI) treatment.Children and Design All children operated for EA during 2001 to 2009 (n

The zinc finger transcription factor Wilms tumour protein (WT 1) is known for its essential involvement in the development of the genitourinary system as well as of other organs and tissues. WT 1 is capable of selectively binding either DNA or mRNA targets. A KTS insertion due to alternative splicing between the zinc fingers 3 and 4 and an unconventional zinc finger 1 are the unique features that

Resource reservation is a technique that allows isolating applications from interfering among each other. In the most classic setting, this method requires the periodic allocation of a given budget of resource over time. However, in reality, the actual budget allocation may deviate from its ideal value. Examples of causes of this deviation are: the presence of a system tick, the usage of shared re

We report on low-temperature magnetotransport and SQUID measurements on heavily doped Mn-implanted GaAs nanowires. SQUID data recorded at low magnetic fields exhibit clear signs of the onset of a spin-glass phase with a transition temperature of about 16 K. Magnetotransport experiments reveal a corresponding peak in resistance at 16 K and a large negative magnetoresistance, reaching 40% at 1.6 K a

Late Svecofennian granite is frequent in the Bothnian Basin, especially in zones of rapidly changing metamorphic grade but also in areas, where the metamorphic grade is elevated. The granite is essentially undeformed, but weakly foliated or lineated rocks are common; more rarely are rocks strongly foliated. X-ray fluorescence was used for major-element and ICP-MS for trace-element analyses. The ch

Background. The last decade has witnessed remarkable developments in medical treatment that is personalised, predictive and preventive. The advances made here have the potential to bring about radical change, not only in diagnostic tests and prescriptions, but also in more fundamental patterns in the provision of health care. Methods. The conceptual framework and principles of modern decision theo

Excess alcohol consumption and stress are suggested to be key elements in the development of gastrointestinal disorders (Konturek et al., 2011). Dysfunction of the small intestinal barrier function with increased permeability is a common clinical observation in patients with inflammatory bowel syndrome (IBS) and alcoholic liver disease (Sommansson et al., 2013b). Therapeutic administration of the

We present a methodology to determine the camouflage effectiveness of static nets in a SAR image. There is currently no common recognized methodology within the signature management community in this research topic. One step towards establishing a common methodology is to use a standardized target to be camouflaged. We use the STANdard Decoy for CAmouflage Materials (STANDCAM) target developed by

We hypothesized that treating distal radius fractures with cast only or closed reduction and cast is associated with high malunion risk and that the risk is higher in patients with low bone mineral density (BMD).

The dissociation behavior of proton conducting sulfonated polysulfones has been investigated by combining electrophoretic NMR, pulsed magnetic field gradient NMR and conductivity meas- urements on monomeric and polymeric samples with concentrations of ionic groups in the range where dissociation is not complete (IEC = 4.55 – 7.04 meq g-1). In this regime, counterion con- densation is shown to crit

The combustion timing in internal combustion engines affects the fuel consumption, in-cylinder peak pressure, engine noise and emission levels. The combination of an in-cylinder pressure sensor together with a direct injection fuel system lends itself well for cycle-to-cycle control of the combustion timing. This paper presents a method of controlling the combustion timing by the use of a cycle-t