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Adipocytes are crucial energy reservoirs to maintain metabolic homeostasis of glucose and lipids in the human body.Glucose transporters (GLUTs) and aquaporins (AQPs) play an important role in metabolic regulation of glucose andlipids in human adipocytes. Specifically, glucose transporter 4 (GLUT4) and aquaporin 7 (AQP7) are the centralplayers for glucose transport and glycerol efflux in adipocytes
During eyeblink conditioning, Purkinje cells that control the eyelid learn to respond with a pause in simple spike firing to the conditional stimulus. This conditional pause response (CR) in the Purkinje cell is adaptively timed and drives the overt response. Recent results show that the Purkinje cell CR does not depend on modification of synaptic strength such as long-term depression but on a nov
BACKGROUND: This study aimed to estimate the birth prevalence of children born with isolated or non-isolated clubfoot in Sweden using a national clubfoot register. Secondarily we aimed to describe the clubfoot population with respect to sex, laterality, severity of deformity, comorbidity and geographic location.METHODS: A national register, the Swedish Pediatric Orthopedic Quality register, was us
Purpose: This paper focuses on the extent to which Swedish municipalities identified and communicated risks due to the COVID-19 outbreak early on. The purpose of this paper is to explore to what extent the situational factors of the COVID-19 pandemic influenced the likelihood of municipalities disclosing COVID-19 information as a subsequent event in the annual reports of 2019. Design/methodology/a
Businesses in the present era are dealing with a complex and unprecedented brew of social, environmental, and technological trends. This requires sophisticated, sustainability-based management. Yet organizations are often reluctant to place sustainability core to their business strategies with the mistaken belief that the costs associated with environmental investments outweigh the benefits. The G
The aim is to describe the development of a novel interdisciplinary graduate school, using the Swedish National Graduate School for Competitive Science on Ageing and Health (SWEAH) as a case example. We explore doctoral students’ perceptions of being part of SWEAH and provide implications for practice. Written self-reports reflecting 78 students’ experiences and perceptions were analyzed using the
Background and aims: The precursor peptide of vasopressin, copeptin, has previously been linked to increased risk of developing diabetes mellitus, coronary artery disease and cardiovascular mortality. Whether elevated copeptin is associated with markers of atherosclerosis and arteriosclerosis in the general population is not known. Methods: In this population-based, cross-sectional study, coronary
BACKGROUND: Individuals with attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) can experience obstacles in traditional health care situations due to difficulties associated with their impairment.OBJECTIVE: This controlled study aims to investigate the feasibility of an internet-based support and coaching intervention (IBSC), including 2 weekly chat sessions and 2 c
Single-cell RNAseq is a routinely used method to explore heterogeneity within cell populations. Data from these experiments are often visualized using dimension reduction methods such as UMAP and tSNE, where each cell is projected in two or three dimensional space. Three-dimensional projections can be more informative for larger and complex datasets because they are less prone to merging and flatt
Galectin-8 is a carbohydrate-binding protein that plays a crucial role in tumor progression and metastasis, antibacterial autophagy, modulation of the immune system, and bone remodeling. The design, synthesis, and protein affinity evaluation of a set of C-3 substituted benzimidazole and quinoline d-galactal derivatives identified a d-galactal-benzimidazole hybrid as a selective ligand for the gale
Our paper about the impacts of the Laschamps Geomagnetic Excursion 42,000 years ago has provoked considerable scientific and public interest, particularly in the so-called Adams Event associated with the initial transition of the magnetic poles. Although we welcome the opportunity to discuss our new ideas, Hawks’ assertions of misrepresentation are especially disappointing given his limited examin
In platform software ecosystems, organizations partner and innovate together. Success and innovation depend on managing complex sets of business relationships and stakeholders and using a requirements-selection process. We describe the associated challenges and strategies from the study of two large proprietary platform ecosystems.
People can judge a stranger's trustworthiness at first glance solely based on facial appearance. Moreover, the trust behaviors people exhibit toward strangers differ depending on perceived trustworthiness from faces. Research has found that people have different risk preferences according to the gain or loss frame. Therefore, we hypothesized that the risk decisions are differently affected by faci
Early Christian heresiology is, like polemics in general, a genre that has commonly been negatively perceived in scholarship. There is an idea of heresiological texts as not only historically unreliable, but also unproductive, in contrast to the creative thinking that can be found in theological treatises. Considering the understanding of heresiology as reactive and exclusive, it is not surprising
Beamforming technology plays a significant role in source localization and quantification. As traditional delay-and-sum beamformers generally yield low spatial resolution, as well as suffer from the occurrence of spurious sources, different forms of deconvolution methods have been proposed in the literature. In this work, we propose two approaches based on a sparse reconstruction framework combine
This paper investigates the stabilization of underactuated vehicles moving in a three-dimensional vector space. The vehicle's model is established on the matrix Lie group SE(3), which describes the configuration of rigid bodies globally and uniquely. We focus on the kinematic model of the underactuated vehicle, which features an underactuation form that has no sway and heave velocity. To compensat
The usefulness of blood culture time-to-positivity (TTP) in the diagnosis of endovascular infections has previously been shown. Here, we investigated TTP in 41 patients with F. necrophorum bacteraemia and found an association between short TTP and Lemierre's syndrome (p = 0.026).
Background: There is an increasing interest in the potential health benefits of positive psychological states, especially with regard to cardiovascular health. Life satisfaction is thought to be a constituent component of psychological well-being; however, among the few previous studies that have investigated its associations with early stages of the cardiovascular disease process, only one small
Information Systems Interactions are a pivotal point in developing an understanding of a socio-technical system. From this perspective, Information Systems could be defined as the cooperation, coexistence and integration of a socio-technical approach with the social aspect. This research investigates how people communicate in a business and how this is likely to support knowledge sharing practices
Behind everything we do in our daily lives there is a reason for doing it. This paper looks into the motives behind DDoS attacks as a form of cyberattack along with attacker personas. This paper also investigates DDoS attacks technically and it is suggested that there is a need for a socio-technical approach to these attacks to investigate why they occur and the reasoning the attacker(s) could hav
