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Background: Accurate markers for prostate cancer (PC) risk stratification could aid decision-making for initial management strategies. The 4Kscore has an undefined role in predicting outcomes after radical prostatectomy (RP). Methods: We included 1476 patients with 4Kscore measured prior to RP at two institutions. The 4Kscore was assessed for prediction of adverse pathology at RP and biochemical r

How might a liberal democratic community best regulate human genetic engineering? Relevant debates widely deploy the usually undefined term “human dignity.” Its indeterminacy in meaning and use renders it useless as a guiding principle. In this article, I reject the human genome as somehow invested with a moral status, a position I call “genetic essentialism.” I explain why a critique of genetic e

This chapter proceeds from the contention that analysing power, oppression, and dominance together – particularly accounting for the experience of being subjected to oppression and dominance in a context of power – reveals deficiencies in what is here referred to as the standard view of what power is. On the standard view, “power” is a purposive capacity concept about what some people do or can do

Republican political theory, with its commitment to a political and personal conception of freedom in terms of the absence of domination, has the potential to revitalize how we think about human rights. From a republican perspective, the aims of the politics of human rights are—in negative terms—to end exploitation, vulnerability, and precarity and—in positive terms—to establish a society of equal

Introduction: Harboring two copies of the apolipoprotein E (APOE) ε2 allele strongly protects against Alzheimer's disease (AD). However, the effect of this genotype on gray matter (GM) volume in cognitively unimpaired individuals has not yet been described. Methods: Multicenter brain magnetic resonance images (MRIs) from cognitively unimpaired ε2 homozygotes were matched (1:1) against all other AP

This paper investigates the drivers for, and implementation of, digital transformation projects and organizational change initiatives in 20 companies in the UK. The study follows on previous research based on the Socio-Technical Toolbox [STT], specifically focusing on the activity analysis and employees’ experience and participation in the change initiative or digital transformation project.

Annelien de Dijn’s Freedom: An Unruly History is a rich and thought-provoking work in intellectual history, tracing thinking and debating about political freedom in the West from ancient Greece to our own times. The ancient notion of freedom as self-government (what Quentin Skinner calls neo-roman liberty) is referred to as the ‘democratic conception’. The argument is that this conception survived

Red cell distribution width (RDW) is a measure of the variability of erythrocyte volumes. RDW has been associated with incidence of cardiovascular diseases. However, the underlying mechanisms for the increased cardiovascular risk are still unclear. This study aimed to examine associations of RDW and coronary atherosclerosis in the general population. Computed tomography was performed and RDW was m

Background: The second stage of labour is generally considered as an intensive part of labour. Despite this, knowledge about women's experiences of the second stage of labour is scant. Aim: To explore experiences of the second stage of labour in women with spontaneous vaginal birth. Methods: This is a qualitative study where twenty-one women with a spontaneous birth at term, were interviewed four

Inom den moderna universitetsvärlden är filosofi inte en brett utforskande intellektuell verksamhet utan ett “ämne”, en “disciplin”, med interna normer och traditioner för vad man gör, hur man gör det och vad som är ett filosofiskt problem. Hur filosofi som akademisk disciplin förhåller sig till andra discipliner är en stor fråga, men delvis kan den illustreras av hur det är att som filosof verka

This article surveys the reception of the Gnostic text Pistis Sophia in esoteric milieus in nineteenth- and early twentieth-century Europe. The first part of the article contains an overview of the text and scholarship on it. Then follows a study of the reception of Pistis Sophia in a broader array of esoteric circles. It becomes clear that the text was hailed as an example of ancient and great spThis article surveys the reception of the Gnostic text Pistis Sophia in esoteric milieus in nineteenth- and early twentieth-century Europe. The first part of the article contains an overview of the text and scholarship on it. Then follows a study of the reception of Pistis Sophia in a broader array of esoteric circles. It becomes clear that the text was hailed as an example of ancient and great sp

Background: During the 21st century, diabetes mellitus (DM) and peripheral artery disease (PAD) have become global problems. It is estimated that 19-34% of individuals with DM will develop a foot ulcer during their lifetime, and many will be amputated.Aim:-To study dietary and lifestyle factors associated with prevention of PAD among individuals with DM. -To evaluate outcomes after vascular and en

The number of traffic-related fatalities has dropped significantly in the last few decades, but the trend in fire safety, albeit positive, show a less rapid improvement. One reason could be the introduction of the Euro-NCAP-system in traffic safety which has been instrumental in promoting innovation in the field. In this report, a first version of a similar system for smoke alarms, arguably a most

We study the steady Euler equations for inviscid, incompressible, and irrotational water waves of constant density. The thesis consists of three papers. The first paper approaches the Euler equations through a famous nonlocal model equation for gravity waves, namely the Whitham equation. We prove the existence of a highest gravity solitary wave which reaches the largest amplitude and forms a $C^{1

Research on party competition and political representation relies on valid cross-national measures of party po- sitions. This research note reports on the 1999–2019 Chapel Hill expert survey (CHES), which contains measures of national party positioning on European integration, ideology, and several European Union (EU) and non-EU policies for six waves of the survey, from 1999 to 2019. The trend fi

There are several well-known risk factors for work-related musculoskeletal disorders (MSDs). Despite this knowledge, too many people still work in harmful conditions. The absence of occupational exposure limits (OELs) for physical workload impedes both supervision and preventive work. To prevent myalgia, tendon disorders, and nerve entrapments in the upper musculoskeletal system, we propose action

Behavioral responses to novelty, including fear and subsequent avoidance of novel stimuli, i.e., neophobia, determine how animals interact with their environment. Neophobia aids in navigating risk and impacts on adaptability and survival. There is variation within and between individuals and species; however, lack of large-scale, comparative studies critically limits investigation of the socio-eco