Optic neuritis (ON) is associated with numerous immune-mediated inflammatory diseases, but 50% patients are ultimately diagnosed with multiple sclerosis (MS). Differentiating MS-ON from non-MS-ON acutely is challenging but important; non-MS ON often requires urgent immunosuppression to preserve vision. Using data from the United Kingdom Biobank we showed that combining an MS-genetic risk score (GR

Background: Following exposure to traumatic stress, women are twice as likely as men to develop mood disorders. Yet, individual responses to such stress vary, with some people developing stress-induced psychopathologies while others exhibit resilience. The factors influencing sex-related disparities in affective disorders as well as variations in resilience remain unclear; however, emerging eviden

DNA mismatch repair (MMR) is thought to contribute to the onset and progression of Huntington disease (HD) by promoting somatic expansion of the pathogenic CAG nucleotide repeat in the huntingtin gene (HTT). Here we have studied constitutional HTT CAG repeat size in two cohorts of individuals with Lynch syndrome (LS) carrying heterozygous loss-of-function variants in the MMR genes MLH1 (n = 12/60;

We introduce benchmarking analysis based on state-of-the-art machine learning techniques applied to the measurement of efficiency to assess the performance of Higher Education Institutions (HEIs). We rely on Efficiency Analysis Trees (EAT) and its Convexified frontier counterpart (CEAT) to assess the efficiency of 144 private HEIs in Colombia and compare the results with those achieved with classi

Cognitive skills affect individual choices. Researchers commonly use Raven's Progressive Matrices (RPM) tests and the Cognitive Reflection Test (CRT) to assess the relationship between cognitive abilities and economic decision making. In this paper, we study the relationship between these measures, and investigate the extent to which they are correlated and whether they are best described as subst

Pollutions on and within the underground poses risks for groundwater contamination and is a widespread global problem. Common remediation methods based on digging and removal can be expensive and have limitations, while in-situ remediation is an attractive alternative. However, there is a need to develop tools to monitor the effectiveness both in terms of the successful injection of remediation fl

Standard treatment for patient with peritoneal metastases from colorectal cancer is cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). In recent years, the efficacy of oxaliplatin-based HIPEC has been challenged. An intensified HIPEC (oxaliplatin+irinotecan) in combination with early postoperative intraperitoneal chemotherapy (EPIC) has shown increased recurrence-fr

The Nobel Prize in Literature to the Austrian writer Peter Handke in 2019 gave new attention to one of the basic, and historically highly disputed (cf. Espmark 2001, 2021), questions in relation to the practice of the world’s most important literary prize – on what grounds, aesthetic or otherwise, does the Swedish Academy award the prize? In the aftermath of the 2019 prize to Handke, there was an

Cardio-metabolic traits have been reported to be associated with the development of sepsis. It is, however, unclear whether these co-morbidities reflect causal associations, shared genetic heritability, or are confounded by environmental factors. We performed three analyses to explore the relationships between cardio-metabolic traits and sepsis. Mendelian randomization (MR) study to evaluate the c

Den som använder äldreomsorg möter ofta personal som är utlandsfödd eller har en annan etnicitet än den svenska. Syftet med den här studien var att undersöka äldre hemtjänstanvändares uppfattningar om ”utländsk” personal. Studien baseras på 34 intervjuer med äldre som använder hemtjänst. Resultaten visade att språkproblem var vanliga, men att den övervägande bilden av personalen var positiv, vilke

Aim: To provide a comprehensive description of the clinical features, biochemical characteristics, and outcomes of infants up to 90 days old with COVID-19. Moreover, to assess the severity of the disease and propose an effective management pathway. Methods: Retrospective single-center study spanning three years. Patient data includes age, sex, symptoms, comorbidities, blood and urine test results,

The current landscape of biopharmaceutical production necessitates an ever-growing set of tools to meet the demands for shorter development times and lower production costs. One path towards meeting these demands is the implementation of digital tools in the development stages. Mathematical modelling of process chromatography, one of the key unit operations in the biopharmaceutical downstream proc

In this paper we reflect on how bordering emerge in urban integration processes in relation to two geopolitical belongings. The paper emanates from a performative dialogic event, labelled Lund Irbid Parallel Walk connecting two geopolitical regions: one in Europe through the city of Lund in the South of Sweden, and one in the Middle East that is Irbid located in the North of Jordan. Here, we refle

Previous research on learning to contract and contracting capabilities suggests that firms in interorganizational relationships adopt contractual designs that economize on transaction costs, and over time learn to govern their relationships in a more efficient manner by incrementally aligning contractual terms with transaction attributes based on new experiences made in their relationships. We aug

The size of the authentication tag represents a significant overhead for applications that are limited by bandwidth or memory. Hence, some authenticated encryption designs have a smaller tag than the required privacy level, which was also suggested by the NIST lightweight cryptography standardization project. In the ToSC 2022, two papers have raised questions about the IND-CCA security of AEAD sch

People with a refugee background are at significantly increased risk of mental health difficulties, including Post-Traumatic Stress Disorder (PTSD). There is a large evidence base showing that trauma-focused psychological treatments for PTSD are effective. However, the majority of trials do not include refugees and less is known about how refugees respond to treatment. The present report explores

Current treatment guidelines refer to small cell lung cancer (SCLC), one of the deadliest human malignancies, as a homogeneous disease. Accordingly, SCLC therapy comprises chemoradiation with or without immunotherapy. Meanwhile, recent studies have made significant advances in subclassifying SCLC based on the elevated expression of the transcription factors ASCL1, NEUROD1, and POU2F3, as well as o