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Structure of murine complement component C3. I. Nucleotide sequence of cloned complementary and genomic DNA coding for the beta chain

The nucleotide sequence coding for the beta chain of murine C3 was determined from cloned cDNA and genomic DNA fragments. Sonicated subfragments were randomly inserted into the bacteriophage M13 and sequenced using the dideoxynucleotide technique. Each nucleotide was sequenced on average six times in these studies. The derived amino acid sequence includes a signal peptide and a tetra-arginine sequ

Adaptive Autopilots for Large Tankers

The adaptive autopilots are based on velocity scheduling, a self-tuning regulator for steady state course keeping, a high gain turning regulator with variable structure, and a Kalman filter. Results from simulations and full-scale experiments on three different tankers are presented. The autopilots are shown to work excellently under different loads, speed and weather conditions.

The long-term cognitive outcomes of Alzheimer’s disease — influence of APOE genotype, NSAID therapy, and cholinesterase inhibitor treatment.

Introduction: Heterogeneity in cognitive outcomes and response to treatment has been described in Alzheimer’s disease (AD). Using the method of mixed models, higher resolution can be obtained to identify potential predictors of long-term outcomes. Aims: To analyse the impact of the APOE genotype, non-steroidal anti-inflammatory drug (NSAID) therapy and cholinesterase inhibitor treatment (ChEI) on

Transient Electromagnetic Wave Propagation in Anisotropic Dispersive Media

In this paper transient electromagnetic wave propagation in a stratified, anisotropic, dispersive medium is considered. Specifically, the direct scattering problem is addressed. The dispersive, anisotropic medium is modeled by constitutive relations (a 3 × 3 matrix-valued susceptibility operator)con taining time convolution integrals. In the general case, nine different susceptibility kernels char