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Circulating insulin-like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition

Insulin-like growth factor-I (IGF-I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF-I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF-I concent

Transurethral resection of the prostate : Are we following the guidelines? - Outcomes from the Global Prevalence of Infections in Urology (GPIU) study

Transurethral resection of the prostate (TURP) is one of the most common urological procedures. With the increasing rate of multiresistant infections including urosepsis, it is essential for all surgeons to adhere to the relevant international guidelines to prevent infectious complications. The aim of this prospective, multinational, multicentre study was to evaluate compliance with recommended in

CA19-9 and apolipoprotein-A2 isoforms as detection markers for pancreatic cancer : a prospective evaluation

Recently, we identified unique processing patterns of apolipoprotein A2 (ApoA2) in patients with pancreatic cancer. Our study provides a first prospective evaluation of an ApoA2 isoform (“ApoA2-ATQ/AT”), alone and in combination with carbohydrate antigen 19–9 (CA19-9), as an early detection biomarker for pancreatic cancer. We performed ELISA measurements of CA19-9 and ApoA2-ATQ/AT in 156 patients

Ett pilgrimsbesök i Vadstena år 1432

During a fictional visit to Vadstena in the year 1432 we learn about indulgences, see the future insurgent Engelbrekt, hear the adventures of some shipwrecked Venetians, and listen to a sermon at the Birgittine abbey church.

Linking life-history theory and metabolic theory explains the offspring size-temperature relationship

Temperature often affects maternal investment in offspring. Across and within species, mothers in colder environments generally produce larger offspring than mothers in warmer environments, but the underlying drivers of this relationship remain unresolved. We formally evaluated the ubiquity of the temperature–offspring size relationship and found strong support for a negative relationshipacross a

Patient-reported outcome and experience measures for diabetes : development of scale models, differences between patient groups and relationships with cardiovascular and diabetes complication risk factors, in a combined registry and survey study in Sweden

PURPOSE: The Swedish National Diabetes Register (NDR) has developed a diabetes-specific questionnaire to collect information on individuals' management of their diabetes, collaboration with healthcare providers and the disease's impact on daily life. Our main objective was to develop measures of well-being, abilities to manage diabetes and judgements of diabetes care, and to detect and quantify di

Organizing Professionalism – New Elites, Stratification and Division of Labor

The case in this study is the introduction of a new more prominent position for teachers. The aim is to contribute to the literature on stratification and organizing of professions. This is done by addressing the question how division of labor is affected by enhanced organization of a profession? The paper illustrates how stratification took place and a new division of labor emerged. Not much conf