Pancreatic cancer is one of our most lethal malignancies. Despite substantial improvements in the survival rates for other major cancer forms, pancreatic cancer survival rates have remained relatively unchanged since the 1960s. Pancreatic cancer is usually detected at an advanced stage and most treatment regimens are ineffective, contributing to the poor overall prognosis. Herein, we review the cu

This work treats multi-pitch estimation, and in particular the common misclassification issue wherein the pitch at half of the true fundamental frequency, here referred to as a sub-octave, is chosen instead of the true pitch. Extending on current methods which use an extension of the Group LASSO for pitch estimation, this work introduces an adaptive total variation penalty, which both enforce grou

Disrupted high school experiences, including dropout, are educational consequences for many youth with histories of homelessness. Using an ecological resilience prediction model (ERPM) based on the literature on resilience in at-risk youth, the study followed 82 youth who were initially homeless for a 2-year period, to identify predictors of participating in school. Female sex and increased durati

In order to understand where and how the Swedish public access their medicines, especially prescribed medicines, an online survey was conducted as a pilot study during April and May 2016. Among a collection of 155 answers, the data shows that, although a majority of the respondents feel hesitated and negative towards shopping prescribed medicines online, a tendency is demonstrated that people woul

National incidence and prevalence estimates of homelessness in Canadian youth are unknown. However, a recent annual profile of shelter users in a large urban centre estimated that one in five consumers of emergency shelter services are youth. Adolescence is a period of vulnerability from developmental perspective. In their progression from childhood to adulthood, youth have multiple role transitio

The aim of this article is to analyze reported changes in outdoor mobility, increased/unchanged/decreased, for a sample of older people (>62 years) in two regions in Sweden, who have transitioned from a two-person to a single-person household during the two years since the study was conducted. The target group (N=162) consists of all people who had transitioned to a single-person household in a ra

This paper presents findings on the role of online traveller information services in regional public transport for olderpeople and people with functional limitations. An explanatory mixed methods design was used. A quantitative questionnairestudy of the target group’s need of traveller information and use of online traveller information services provided the basisfor a qualitative focus group stud

In this work we have investigated face verification based on deep representations from Convolutional Neural Networks (CNNs) to find an accurate and compact face descriptor trained only on a restricted amount of face image data. Transfer learning by fine-tuning CNNs pre-trained on large-scale object recognition has been shown to be a suitable approach to counter a limited amount of target domain da

A well-planned waiting area is crucial for automatic milking systems. In an enclosed waiting area, cows of different rank compete for entering the milking station and they are exposed for a variety of social interactions. Such interactions could increase standing time and delay milking, which may result in stress, lameness, impaired welfare and reduced performance. The aim was to monitor the waiti

Jag avser att redogöra för sambandet, eller förhållandet, mellan formlerna 1+1=♥ och (∀a) (Ǝb) (∀c) [[(cϵa) u λ (c)] → (cϵ b)]. Då den förra formeln är hämtad från ett internetforum för personer diagnostiserade med adhd och deras anhöriga, så är den senare hämtad från den franske filosofen Alain Badious (2005a) mängdteori vari han närmar sig en ontologi om varat. Mitt eget avhandlingsprojekt rör d

BACKGROUND: A mutation found in the BRCA1 or BRCA2 gene of a breast tumor could be either germline or somatically acquired. The prevalence of somatic BRCA1/2 mutations and the ratio between somatic and germline BRCA1/2 mutations in unselected breast cancer patients are currently unclear.PATIENTS AND METHODS: Paired normal and tumor DNA was analyzed for BRCA1/2 mutations by massively parallel seque

Lesions of ERBB2, PTEN, and PIK3CA activate the phosphatidylinositol 3-kinase (PI3K) pathway during cancer development by increasing levels of phosphatidylinositol-3,4,5-triphosphate (PIP(3)). 3-Phosphoinositide-dependent kinase 1 (PDK1) is the first node of the PI3K signal output and is required for activation of AKT. PIP(3) recruits PDK1 and AKT to the cell membrane through interactions with the

The social mechanism program has been successful in sociology and neighboring social science disciplines, such as criminology and political science. However, in our view the literature on social mechanisms is still too preoccupied with intratheoretical and metatheoretical discussions, and we find very few empirical applications. This is surprising since one of the basic aims of the social mechanis

In this article, we study the effects of the 2004 terrorist bombings in Madrid on ethnic segregation in Spain. Using large-scale Spanish register data consisting of information on 5.4 million international migration events on a monthly basis and 13.9 million intermunicipal migration events, of which 3.8 million events concern the foreign-born population’s internal migration within Spain, the analy