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The ribosome is an essential drug target as many classes of clinically important antibiotics bind and inhibit its functional centers. The catalytic peptidyl transferase center (PTC) is targeted by the broadest array of inhibitors belonging to several chemical classes. One of the most abundant and clinically prevalent mechanisms of resistance to PTC-acting drugs is C8-methylation of the universally
Boken är en syntes av Osmanska rikets historia från 1200-talet till 1900-talet.
Den nya högerledda regeringen i Finland under Petteri Orpo är i full färd med att göra genomgripande förändringar av den finska arbetsmarknadsmodellen. Det handlar om konflikträtten, lönebildningen, förhandlingssystemet och de sociala förmånerna:•Begränsad rätt till sympatiåtgärder och politiska strejker samt kraftigt ökade böter i samband med olagliga konfliktåtgärder•Statliga medlare får inte go
Many regularized methods, such as the lasso and ridge regression, are sensitive to the scales of the features in the data. As a consequence, it has become standard practice to normalize(center and scale) features such that they share the same scale. For continuous data, the most common strategy is standardization: centering and scaling each feature by its mean andand standard deviation, respective
1961 grundades en ny social rörelse i Sverige. Den fick namnet Kampanjen mot atomvapen (KMA) och var en svensk gren av en internationell, gränsöverskridande rörelse som startat året innan med bas i Västeuropa. Målet med rörelsen var att få supermakterna att avrusta sina kärnvapenrörelser och, för svensk del, att få Sverige att upphöra med sitt pågående kärnvapenprogram. I Sverige spelade KMA en viA new social movement was formed in Sweden in 1961: Kampanjen mot atomvapen (KMA, “The Campaign for Nuclear Disarmament”). Opposing the military’s plans to acquire Swedish nuclear bombs and protesting against the escalating tensions of the Cold War, KMA in the years 1961‒1963 rallied young people and students and introduced several new forms of collective political actions in the Swedish repertoir
Streaming applications, such as MPEG video encoders or sensor processing pipelines, are increasing in complexity as well as the diversity of platforms that they run on. The toolchains handling these applications must keep up with this increase at all levels of abstraction. The Actor Machine (AM) is an intermediate representation in the toolchain that we make use of. Large AMs are difficult to work
Rapporten presenterar resultaten av en studie som vi genomfört på uppdrag av Nätverket Idéburen Sektor Skåne och handlar om idéburna erfarenheter av samverkan med offentliga organisationer inom NAD. Syftet är att förstå hur strukturella förändringar och organisatoriska strategier har påverkat samverkan över tid. Tidsperioden sträcker sig från 2016 då vi genomförde en utvärdering av samverkan och 2
Ghana’s Land Administration Project (LAP), initiated in 2003, aimed to enhance certainty regarding land rights. What has been achieved since then? We explore landowners’ perceptions of tenure security in Ghana using micro-level data from two waves of the Ghanaian Living Standards Surveys: GLSS5+ (2008) and GLSS7 (2017). This data allows us to study the linkages between land title formality and per
Background The popularity of tattoos has increased dramatically over the last few decades. Tattoo ink often contains carcinogenic chemicals, e.g., primary aromatic amines, polycyclic aromatic hydrocarbons, and metals. The tattooing process invokes an immunologic response that causes translocation of tattoo ink from the injection site. Deposition of tattoo pigment in lymph nodes has been confirmed
Mennesker og trær har alltid hatt et nært fellesskap. Hva er det med trær, og hva har de med oss å gjøre? Historiker og teolog Thomas Arentzen oppsøker skoger, klatrer i trær, leser bibelske tekster og dykker ned i historiske kilder. Han finner mennesker som søker trær, men også trær som våker over mennesker. Trærnes evangelium er et essay om et landskap som på samme tid er hverdagslig og fantasti
In this chapter, focus is on the period 1945-1960 and the discussion is divided into three thematic sections: First, macro-economic structures including growth trends and the composition of the economies. Second, colonial budgets including state finance, fiscal capacity, and economic policy. Third, changes in occupations, incomes, and living standards primarily for the African subjects. The text p
Maturity Onset Diabetes of the Young (MODY) is a young-onset, monogenic form of diabetes without needing insulin treatment. Diagnostic testing is expensive. To aid decisions on who to test, we aimed to develop a MODY probability calculator for paediatric cases at the time of diabetes diagnosis, when the existing “MODY calculator” cannot be used. Firth logistic regression models were developed on d
The nature of work has already, for some time, been undergoing major changes as a result of technological progress. Mobile, virtual and cloud technologies, and the infrastructures that support them, are increasingly enabling work to be done from anywhere and at any time. The COVID-19 pandemic has further accelerated this process, driving a large share of white-collar knowledge work to remote and h
This study examines the impact of the extensive climatic and environmental changes associated with the Early Holocene on the feeding ecology of aurochs, European bison, red deer, and Eurasian elk in southern Scandinavia from radiocarbon dates and analysis of stable carbon and nitrogen isotopes. Molecular sex information is utilised in the study of aurochs to understand the underlying reasons behinThis study examines the impact of the extensive climatic and environmental changes associated with the Early Holocene on the feeding ecology of aurochs, European bison, red deer, and Eurasian elk in southern Scandinavia from radiocarbon dates and analysis of stable carbon and nitrogen isotopes. Molecular sex information is utilised in the study of aurochs to understand the underlying reasons behin
BackgroundSwift identification and diagnosis of gastrointestinal infections are crucial for prompt treatment, prevention of complications, and reduction of the risk of hospital transmission. The radiological appearance on computed tomography could potentially provide important clues to the etiology of gastrointestinal infections. We aimed to describe features based on computed tomography of patien
Carpal tunnel syndrome (CTS) occurs more often among individuals with diabetes. The aim of this retrospective observational registry study was to examine whether individuals with diabetes and CTS are treated surgically to the same extent as individuals with CTS but without diabetes. Data on CTS diagnosis and surgery were collected from the Skåne Healthcare Register (SHR). A total of 35,105 individ
Objective. To explore how the perceptions and experiences of working with risky drinkers change over time among primary health care staff during a systematic implementation project. Methods. Qualitative focus group interviews took place before and after the implementation of the project. Results. The staff displayed a positive change during the implementation period with regard to awareness, knowl
AIM: To compare two identification methods for risky drinking in primary health care centres (PHCs).METHODS: Sixteen PHCs from three Swedish counties were randomized into strands: consultation-based early identification (CEI) or systematic screening early identification (SS). Measurements took place at baseline and during two intervention periods. Patients filled in questionnaires including gender
