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Dynastic Marriage Spheres in Early Modern Europe : A Comparison of the Danish Oldenburgs and Three Houses of the Empire

Princely marriages are here seen as a key component in dynasty formation and dynasty securing. The marriages of the Danish royal house and three houses of the Empire are studied for the period c. 1530–1700. Most of them took place within what can be labelled a Scandinavian-German-Lutheran marriage sphere. It was a highly hierarchized sphere with little contact between top (royal and electoral hous

Addressing the Legal Quagmire of Complementary Legal Pathways

Complementary pathways have been offered as a possible solution for facilitating legal admission of people in need of international protection. The current debates about these pathways are characterised by a conceptual and legal quagmire since various issues are invoked and conflated. The objective of this article is to dissect the relevant issues in light of the existing relevant legal frameworks

Lexikal betydelseutveckling i teori och praktik : En analys av fem definitionsformler i Svenska Akademiens ordbok och de semantiska förändringsmekanismer som de beskriver

I avhandlingen undersöks betydelsebeskrivningen i Ordbok över svenska språket utgiven av Svenska Akademien (SAOB) i ljuset av teoretisk semantik. De fem etablerade och i ordbokens definitionstext högfrekventa formlerna, eller semantiska etiketterna, "bildlig", "oegentlig", "utvidgad", "allmännare" och "överförd användning" studeras ur olika perspektiv.Frågan som ställs i avhandlingen är hur formle

Recombinant Protein Production Using the Baculovirus Expression Vector System (BEVS)

The baculovirus expression vector system (BEVS) is one of the most popular eukaryotic systems for recombinant protein production. The focus of our protein production platform is the provision of recombinant proteins for research use, where generally only small quantities are required, in the range of tens of micrograms to a few hundred milligrams. Here, we present methods that reflect our standard

Engineered allele substitution at PPARGC1A rs8192678 alters human white adipocyte differentiation, lipogenesis, and PGC-1α content and turnover

Aims/hypothesisPPARGC1A encodes peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α), a central regulator of energy metabolism and mitochondrial function. A common polymorphism in PPARGC1A (rs8192678, C/T, Gly482Ser) has been associated with obesity and related metabolic disorders, but no published functional studies have investigated direct allele-specific effects in adipocyte bi

EasyNER: A Customizable Easy-to-Use Pipeline for Deep Learning- and Dictionary-based Named Entity Recognition from Medical Text

Medical research generates a large number of publications with the PubMed database already containing >35 million research articles. Integration of the knowledge scattered across this large body of literature could provide key insights into physiological mechanisms and disease processes leading to novel medical interventions. However, it is a great challenge for researchers to utilize this informa

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There is still quite an unknown and unexploited manuscript of the popular medieval French allegorical poem The Romance of the Rose in Stockholm which is curated in the National Library of Sweden under the number Vu 39. This article has as a goal to give the first information and hypothesis we have about it: the origins of this manuscript which is a version of the XVth Century, a description of its

Air pollution in Europe and children’s health

Children are unable to choose their environment and cannot link the sensationof illness to a specific exposure or a certain environment, thus they are powerlessto remove themselves from harmful exposures. It is therefore up to us as guardians and adults to shelter them from these exposures.

Why forced-choice and Likert items provide the same information on personality, including social desirability

Forced-choice response format is often considered superior to standard Likert format for controlling social desirability in personality inventories. We performed simulations and found that the trait information based on the two formats converges when the number of items is high and forced-choice items are mixed with regard to positively and negatively keyed items. Given that forced-choice items ex

Hyper high haemoglobin content in red blood cells and erythropoietic transitions postnatally in infants of 22 to 26 weeks' gestation: a prospective cohort study

Objective Blood cell populations, including red blood cells (RBC) unique to the extremely preterm (EPT) infant, are potentially lost due to frequent clinical blood sampling during neonatal intensive care. Currently, neonatal RBC population heterogeneity is not described by measurement of total haemoglobin or haematocrit. We therefore aimed to describe a subpopulation of large RBCs with hyper high

Pandemics and the built environment : a human-building interaction typology

Surveys of urban history from ancient times to the present reveal a continuum of collective responses to pandemics ranging from quarantine facilities and monitoring the spread of disease to building new wastewater networks. The contemporary COVID-19 pandemic includes new digital tools and techniques that supplement (and sometimes replace) the existing analogue responses, while raising new ethical

A Simple Test Case for Convergence Order in Time and Energy Conservation of Black-Box Coupling Schemes

The most commonly used coupling schemes in partitioned multiphysics simulations suffer from a decrease in the order of convergence, specifically in the time domain; a phenomenon we call order degradation. This paper discusses when this issue arises and how it can be studied with a simple example. We present a simple mass-spring system of ordinary differential equations (ODEs) to analyze accuracy a

Customer Journey Value: A Conceptual Framework

Though firms are making substantial investments in the customer journey (CJ), the return on these investments remains tenuous, yielding a critical need for enhanced CJ-related accountability. Addressing this gap, we develop the concept of ‘customer journey value’ (CJV), defined as the perceived value of a customer’s journey to the customer and the firm, which facilitates the development of account