Penile cancer is a disease with a high morbidity and mortality. Its prevalence is relatively rare, but the highest in some developing countries. Insight into its precursor lesions, pathogenesis and risk factors offers options to prevent this potentially mutilating disease. This review presents an overview of the different histologically and clinically identified precursor lesions of penile cancer

Popular Abstract in Swedish Rörelseorganens sjukdomar är ett samlingsnamn för sjukdomar i skelett, muskler, leder och senor. Rörelseorganens sjukdomar är tillsammans med psykiska sjukdomar den vanligaste orsaken till sjukskrivning i Sverige. I sjukskrivningssammanhang studeras ofta rörelseorganens sjukdomar som en grupp men i själva verket innehåller gruppen en mängd olika sjukdomar och symptom soOsteoarthritis (OA) is one of the most common causes of pain and disability in the musculoskeletal system. Even though the prevalence of OA increases rapidly with age, OA also impacts the working age population. The overall aim of this thesis was to increase the knowledge on sick leave and disability pension in OA and other musculoskeletal disorders (MSDs). Specific aims were to study patients ex

In dibromomesitylene, only the methyl group denoted Me-2 and surrounded by two bromine atoms, is a quasi free rotor. In isotopic mixtures the Me-2 tunnelling gap is almost insensitive to variations in temperature and to isotopic dilution. The Me-2 hindering potential remains the same as in the pure material with a main component cos6 theta. Because there is no coupling between the methyl groups, d

Alterations in cellular pathways related to both endocrine and vascular endothelial growth factors (VEGF) may contribute to breast cancer progression. Inhibition of the elevated levels of these pathways is associated with clinical benefits. However, molecular mechanisms by which endocrine-related pathways and VEGF signalling cooperatively promote breast cancer progression remain poorly understood.

Cartilage oligomeric matrix protein (COMP) is a biomarker of fibrosis in lung and skin. In this exploratory study we investigated the biomarker potential of COMP in chronic hepatitis C (CHC). We included consecutive patients with CHC admitted to the Department of Infectious Diseases, Lund University Hospital. COMP was analysed in serum using ELISA. The correlations between COMP and liver fibrosis,

Introduction: Fenestrated aortic stent-grafts are increasingly being used to treat patients with juxtarenal abdominal aortic aneurysms (AM). Sizing of these stent-grafts is critical to ensure success and requires detailed expert assessment of aortic morphology. At present little is known about how sizing of these stent-grafts varies between observers and the necessary tolerances involved to ensure

Recent investigations of core-shell nanowires using synchrotron radiation techniques deduced the average structural parameters of heterostructure core-shell nanowires. Here, we report on first results and discuss the problems arising when measuring such complex nanostructures by using nanofocusing X-ray techniques. InAs/IAsP core-shell nanowires exhibit a certain bending, the origin of which is de

Using the findings of incident investigations to improve patient safety management is well-established and mandatory under Swedish law. This study seeks to identify the mechanisms behind successful implementation of the recommendations of incident investigations.

A combination method of frequency domain photon migration (FDPM) and gas in scattering media absorption spectroscopy (GASMAS) is used for assessment of the mean optical path length (MOPL) and the gas absorption in gas-filled porous media, respectively. Polystyrene (PS) foams, with extremely high physical porosity, are utilized as sample materials for proof-of-principle demonstration. The optical p

This work studies osteoinduction and bone conduction in polyvinyl alcohol-tetraethylorthosilicate-alginate-calcium oxide (PTAC) biocomposite cryogels along with the synergistic effect of electrical stimulation. In vitro osteoinduction of C2C12 myoblast towards osteogenic lineage is demonstrated through alkaline phosphatase assay, scanning electron microscopy and energy dispersive X-ray spectroscop

A qualified estimate for pretreatment of the macroalgae Chaetomorpha linum for ethanol production was given, based on the experience of pretreatment of land-based biomass. C linum was subjected to hydrothermal pretreatment (HIT), wet oxidation (WO), steam explosion (STEX), plasma-assisted pretreatment (PAP) and ball milling (BM), to determine effects of the pretreatment methods on the conversion o

Problem: Suspected, but objectively absent, rhinosinusitis constitutes a major cause of visits to the doctor, high health care costs, and the over-prescription of antibiotics, contributing to the serious problem of resistant bacteria. This situation is largely due to a lack of reliable and widely applicable diagnostic methods. Method: A novel method for the diagnosis of rhinosinusitis based on non

Stress corrosion cracking occurs due to the synergistic interaction between mechanical load and corrosion reactions. In this study, branching during anodic dissolution driven crack growth is studied using an adaptive FE procedure. The crack has an inherent blunt tip due to the dissolution, and the growth is treated as a moving boundary problem with a strain-assisted evolution law. Simulations are

Rapidly permineralized fossils can provide exceptional insights into the evolution of life over geological time. Here, we present an exquisitely preserved, calcified stem of a royal fern (Osmundaceae) from Early Jurassic lahar deposits of Sweden in which authigenic mineral precipitation from hydrothermal brines occurred so rapidly that it preserved cytoplasm, cytosol granules, nuclei, and even chr