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Beneficial effects of low-dose prostacyclin on cat intestinal perfusion during endotoxemia as evaluated with microdialysis and oxygen transport variables

Objective: To evaluate the effects of low-dose prostacyclin on intestinal perfusion during endotoxemia. Design: A randomized, blinded experimental study. Setting: A university laboratory. Subjects: Sixteen anesthetized cats. Interventions: The animals received endotoxin by continuous intravenous infusion (0.5 mg/kg plus 0.5 mg kg(-1).hr(-1)) and a continuous volume replacement throughout the exper

Chemotherapy in Ewing's sarcoma. The Scandinavian Sarcoma Group experience

During the past 15 years the Scandinavian Sarcoma Group has treated 140 patients with Ewing's sarcoma. Two protocols have been used. SSG IV included 52 patients between 1984 and 1990 and SSG IX, 88 patients since 1990. After 5 years of treatment, local recurrences occurred in 19% of the patients (M0 + M1) in the SSG IV group and 10% in the SSG IX group. Distant metastases developed in 57% of the M

Moisture permeability of mature concrete, cement mortar and cement paste

Moisture permeability tests were performed on specimens of concrete, cement mortar and cement paste with the bottom side in water or in moist air and the upper side in a relative humidity of 33 %. The distribution of the relative humidity within the specimen was measured, at stationary conditions, as well as the amount of water which pass through the specimen. The depth of the specimens was varie

Severe Developmental Language Disorder - Reading And Spelling - A Longitudinal-Study Of 2 Nonidentical Twins

Linguistic awareness i.e. the ability to identify phonemes, to segment words into syllables and to rhyme is highly correlated with reading/spelling proficiency. Children with severe developmental language disorders DLD (syntagmatic type) have been shown to specifically lack linguistic awareness. Two non-identical twin boys with severe, specific DLD were studied longitudinally with respect to their

Catalytic and structural effects of W-substitution in M2 Mo-V-Te-oxide for propene ammoxidation

Substitution of W for the Mo in M2-type Mo-V-Te-oxide was investigated. XRD, FTIR, XANES, and HRTEM verified that the substitution is possible in the whole range up to complete replacement of Mo by W. Catalytic measurements for propene ammoxidation show that both the specific activity and the selectivity to acrylonitrile pass through a maximum with increase of the W-content of the catalyst. XRD an

Absorption of infrared radiation and the radiation transfer mechanism in paper. Part I: Theoretical model

Infrared dryers, both gas fired and electrically healed, have become a widespread technology in the paper industry. This work proposes a model for the absorption of thermal radiation in the thickness direction of a paper sheet. The model is based on the multilayer idealization of a paper sheet proposed by Scallan and Porch. In this model, the optical properties of paper are considered as the resul

Computerized image analysis as a tool to quantify infiltrating leukocytes : a comparison between high- and low-magnification images

The purpose of the present study was to establish a rapid and reproducible method for quantification of tissue-infiltrating leukocytes using computerized image analysis. To achieve this, the staining procedure, the image acquisition, and the image analysis method were optimized. Because of the adaptive features of the human eye, computerized image analysis is more sensitive to variations in staini

The wholeness of a cybernetican

It is our impression that Gordon Pask’s writings cover fundamentals for large parts of the widely expanding fields of Cybernetics and Systems Theory. Thereby, and by his lecturing activities, he has become a unique figure in maintaining a kind of unity of the field of Cybernetics, well in accord with Wiener’s view (“control and communication in the animal and the machine”; cf[26]). And that, with

On Millian Discontinuities

Suppose one sets up a sequence of less-and-less valuable objects such that each object in the sequence is only marginally worse than its immediate predecessor. Could one in this way arrive at something that is dramatically inferior to the point of departure? It has been claimed that if there is a radical value difference between the objects at each end of the sequence, then at some point there mus

Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system

Previous studies have used recombinant adeno-associated viral (rAAV) vectors to deliver glial cell line-derived neurotrophic factor (GDNF) in the substantia nigra to protect the nigral dopamine (DA) neurons from 6-hydroxydopamine-induced damage. However, no regeneration or functional recovery was observed in these experiments. Here, we have used an rAAV-GDNF vector to express GDNF long-term (6 mon

Decreased levels of ionized calcium one year after hemithyroidectomy: importance of reduced thyroid hormones

BACKGROUND: Previously we have found reduced levels of total serum calcium and 1,25(OH)2D3 despite an unaltered stimulated parathyroid hormone (PTH) secretion 1 year after hemithyroidectomy. The present study was undertaken to elucidate the possible relationship between calcium homeostasis, thyroid hormones and bone resorption in a group of 45 consecutive patients subjected to hemithyroidectomy be

Protein folding in the absence of a clear free-energy barrier

Many small proteins fold in a two-state manner, the rate-limiting step being the passage of the free-energy barrier separating the unfolded state from the native one. The free-energy barrier is, however, weak or absent for the fastest-folding proteins. Here a simple diffusion picture for such proteins is discussed. It is tested on a model protein that makes a three-helix bundle. Assuming the motio