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In this paper, we present a new modular approach to immobilize boronic acid ligands that can offer effective separation of glycoproteins. A new "clickable" boronic acid ligand was synthesized by introducing a terminal acetylene group into commercially available 3-aminophenyl boronic acid. The clickable ligand, 3-(prop-2-ynyloxycarbonylamino)phenylboronic acid (2) could be easily coupled to azide-f
A mild, efficient, Lewis acid promoted addition of C3-substituted 1,3-bis(silyl)propenes to aldehydes to provide the corresponding 2,3,4,5-tetrasubstituted tetrahydrofurans in excellent stereoselectivity is reported. (C) 2013 Elsevier Ltd. All rights reserved.
B-cell leukemia 3 (Bcl-3) is a member of the inhibitor of κB family, which regulates a wide range of biological processes by functioning as a transcriptional activator or as a repressor of target genes. Elevated expression, sustained nuclear accumulation, and uncontrolled activation of Bcl-3 causes increased cellular proliferation or survival, dependent on the tissue and type of stimuli.
Partial preferences may occur due to differences in profitability and encounter probability between food types within a patch. In the expanding specialist diet strategy, a forager goes from being partially selective on the preferred, most profitable food, to being opportunistic, after the preferred food has been depleted to a certain critical level. We studied the diet selection strategies of bird
In recent years the use of repetition rate multiplication (RRM) on direct geometry neutron spectrometers has been established and is the common mode of operation on a growing number of instruments. However, the chopper configurations are not ideally optimised for RRM with a resultant 100 fold flux difference across a broad wavelength band. This paper presents chopper configurations that will produ
An improved synthetic route to the bicyclo[2.2.2]octane-2,6-diol ligands (2,6-BODOLS) allowed an increased structural variation of the ligand side-arm. The addition of aromatic or vinylic Grignard reagents to hydroxyketone 1 was highly selective and ligands 3f-3I were isolated in 84-97% yield. The addition of alkyl Grignard reagents containing beta-hydrogens resulted in lower yields (13-71%) due t
Background: Stroke is a major cause of mortality and morbidity across the world. Air pollution has become an acknowledged risk factor for stroke, especially for acute effects. There is less support for effects by chronic exposure due to the methodological challenges inherent in such studies. Such challenges can regard missing individual level data or residual confounding and can partly be overcome
Background: Breast cancer is the most common malignancy afflicting women, and the most common cancer overall in Jordan. A woman's decision to go for screening is influenced by her social support network. This study aims to explore Jordanian men's individual and contextual perspectives on women's breast cancer and their own role in the breast health of the females within their families. Methods: An
This article presents how food consumption has become an important part of modern football and the way in which commercialization of football clubs is perceived by supporters. Taking the Swedish club Malmö FF as an example, the article explores how the straightforward pattern of consumerism is problematized as fans are able to express a strong feeling of co-creation and even ownership of their bel
Little in general is known about how heme proteins are assembled from their constituents in cells. The Gram-positive bacterium Enterococcus faecalis cannot synthesize heme and does not depend on it for growth. However, when supplied with heme in the growth medium the cells can synthesize two heme proteins; catalase (KatA) and cytochrome bd (CydAB). To identify novel factors important for catalase
Electron transfer (ET) reactions of truncated hemoglobin from Bacillus subtilis (trHb-Bs) are suggested to be implicated in biological redox signalling and actuating processes that may be used in artificial environment-sensing bioelectronic devices. Here, kinetics of ET in trHb-Bs covalently attached via its surface amino acid residues either to COOH- or NH2-terminated (CH2)(2-16) alkanethiol SAM
Recently, we have seen an intensified development of head mounted displays (HMD). Some observers believe that the HMD form factor facilitates Augmented Reality (AR) technology, a technology that mixes virtual content with the users' view of the world around them. One of many interesting use cases that illustrate this is a smart home in which a user can interact with consumer electronic devices thr
Introduction. In recent years, there has been a growing interest in ethnographic research within the field of library and Information studies. Although ethnography has been used by information researchers for studying a wide variety of phenomena, discussions concerning methodological developments and directions, as well as ethnography’s wider applicability within the field are rare. Our intent is
The paper specifies a quantitative methodology for exploring development blocks. The concept of 'development block' was a major contribution to the historical analysis of industrial transformation by the late Erik Dahmen, but development blocks have mainly been analyzed by qualitative methods and indirect indicators and not statistically identified. In this paper, development blocks are identified
Using the Swedish Medical Birth Registry (MBR), obstetrical and demographic information was retrieved for 250 children with autism or Asperger syndrome who were born in Malmoe, Sweden, and enrolled at the local Child and Youth Habilitation Center. The reference group consisted of all children born in Malmoe during 1980-2005. Obstetric sub-optimality (prematurity, low Apgar scores, growth restricti
BL13-XALOC is currently the only macromolecular crystallography beamline at the 3 GeV ALBA synchrotron near Barcelona, Spain. The optics design is based on an in-vacuum undulator, a Si(111) channel-cut crystal monochromator and a pair of KB mirrors. It allows three main operation modes: a focused configuration, where both mirrors can focus the beam at the sample position to 52 mu m x 5.5 mu m FWHM
