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Perchloroethylene: Effects on body and organ weights and plasma buturylcholinesterase activity in mice

The effects of continuous and intermittent inhalation of perchloroethylene (PCE) on plasma butyrylcholinesterase (BuChE) activity, organ weights, liver morphology and motor activity in mice (strain NMRI) were tested. PCE exposure increased plasma BuChE activity in a time- and concentration dependent manner in both sexes. The increase was statistically significant at 37 p.p.m. in animals continuous

A systematic overview of radiation therapy effects in brain tumours

A systematic review of radiation therapy trials in several tumour types was performed by The Swedish Council of Technology Assessment in Health Care (SBU). The procedures for evaluation of the scientific literature are described separately (Acta Oncol 2003; 42: 357-365). This synthesis of the literature on radiation therapy for brain turnouts is based on data from 9 randomized trials and 1 meta-an

Relevance of philosophy of life and optimism for psychological distress among individuals in a stage where death is approaching

The purpose was to investigate the relevance of philosophy of life as well as optimism for the psychological distress among Swedish individuals in a stage where death is approaching. Sixty-nine persons were included; of these were 42 patients newly diagnosed with advanced gastrointestinal cancer and 26 were partners to these patients. The participants' philosophy of life was studied through a semi

Irregular walks and loops combines in small-scale movement of a soil insect: implications for dispersal biology

Analysis of small-scale movement patterns of animals we may help to understand and predict movement at a larger scale, such as dispersal, which is a key parameter in spatial population dynamics. We have chosen to study the movement of a soil-dwelling Collembola, Protaphorura armata, in an experimental system consisting of a clay surface with or without physical obstacles. A combination of video re

3D domain-swapped human cystatin c with amyloidlike intermolecular beta-sheets

Oligomerization of human cystatin C (HCC) leads to amyloid deposits in brain arteries, and this process is greatly accelerated with a naturally occurring L68Q variant. The crystal structures of N-truncated and full-length HCC (cubic form) showed dimer formation via three-dimensional (3D) domain swapping, and this observation has led to the suggestion that an analogous domain-swapping mechanism, bu

Blood Pressure Control and Risk of Stroke. A Population-Based Prospective Cohort Study.

Background and Purpose— Adequate control of blood pressure (BP) is a cornerstone in stroke prevention. This study explored the risk of stroke in relation to the quality of BP control in a population-based cohort and whether control of hypertension was related to background characteristics of patients. Methods— A total of 27 936 subjects (10 953 men and 16 983 women), 45 to 73 years old, living in

Non-adrenergic, non-cholinergic neural activation in guinea-pig bronchi: powerful and frequency-dependent stabilizing effect on tone

1 We examined non-adrenergic, non-cholinergic (NANC) stimulation for its stabilizing effect on bronchial smooth-muscle tone with respect to its regulatory power and the effect of variations in neural impulse frequency. 2 The guinea-pig isolated main bronchus (n = 4-12) was pretreated with indomethacin (1O JAM) and incubated with atropine (1 pM) and guanethidine (10 JM). Electrical field stimulatio

Women's Human Rights and Islam : a Study of Three Attempts at Accommodation

Popular Abstract in Swedish Avhandlingen tar avstamp i en pågående internationell diskussion om kvinnors mänskliga rättigheter och islam. I denna diskussion kan olika muslimska ståndpunkter identifieras. En del avvisar mänskliga rättigheter, såsom dessa formulerats i internationella människorättsdokument, som ”västerländska” påfund och hävdar de religiösa källornas överordnade auktoritet. För andrThe dissertation focuses on interpretations of Islam that claim compatibility with international human rights norms in the context of women’s rights. These interpretations are seen as parts of an on-going contemporary international debate on women’s human rights and Islam that engages Muslims as well as non-Muslims. Existing UN-formulated international human rights schemes are a basic starting poi

The novel IgD binding protein from Moraxella catarrhalis induces human B lymphocyte activation and Ig secretion in the presence of Th2 cytokines.

Moraxella IgD binding protein (MID) is a novel bacterial outer membrane protein with IgD-binding properties. MID was purified from the respiratory pathogen Moraxella catarrhalis and is here shown to have B cell stimulatory properties. Purified MID in the range of 0.01-0.1 microg/ml was optimal to induce a proliferative response in human PBL. MID coupled to Sepharose and formalin-fixed M. catarrhal

Down-regulation of cyclic-nucleotide phosphodiesterase 3B in 3T3-L1 adipocytes induced by tumour necrosis factor alpha and cAMP

We have used murine 3T3-L1 cells, which differentiate in culture and acquire morphological and biochemical features of mature adipocytes, as a model for studying the expression of cyclic-nucleotide phosphodiesterase (PDE) 3B activity, protein and mRNA during differentiation and during long-term treatment of the cells with tumour necrosis factor alpha (TNF-alpha), a cytokine associated with insulin

Assessing the Importance of Letter Pairs in Initial, Exterior, and Interior Positions in Reading

Exterior letter pairs (e.g., d_k in dark) play a major role in single-word recognition, but other research (D. Briihl & A. W. Inhoff, 1995) indicates no such role in reading text. This issue was examined by visually degrading letter pairs in three positions in words (initial, exterior, and interior) in text. Each degradation slowed reading rate compared with an undegraded control. However, whe

The gene expression response of breast cancer to growth regulators: Patterns and correlation with tumor expression profiles

The effects of hormone and growth factor signaling on gene expression contribute significantly to breast tumorigenesis and disease progression; however, the targets of signaling networks associated with deregulated growth are not well understood. We defined the dynamic transcriptional effects elicited in MCF7, T-47D, and MDA-MB-436 breast cancer cell lines by nine regulators of growth and differen

Notes on Pseudoinverses : Application to Identification

In this report we will discuss the possibilities of defining a "good solution" of a system of linear equations. Ax=b where A is not necessarily quadratic. Especially the least squares problem will be treated. The concepts of pseudo inverses are introduced and its application to the least squares problem is shown. Geometrical interpretation of the solution in different cases is given. Different al

Nyfikenhet, kritiskt tänkande och kvalitet

Universitetsläraren är för det mesta en pedagogisk amatör. En amatör är en "icke yrkesmässig utövare av något" men samtidigt en "älskare av något" (Wessén 1982). Med en lätt tolkning kan man alltså säga att en amatör utövar en verksamhet med kärleken som drivkraft. Detta kan då sättas i motsats till den professionelle utövaren som inte primärt har kärlek som drivkraft. En utvecklingstendens som i

Term breech delivery in Sweden: mortality relative to fetal presentation and planned mode of delivery

Objectives. To compare perinatal and infant mortality in breech and cephalic presentations and between planned vaginal and cesarean section (CS) breech deliveries in Sweden. Methods. The study comprised two parts. Study A is a national cohort study for the period 1991-2001, including 22 549 breech presentations and 875 249 cephalic presentations born at >= 38 completed weeks. Study B is a case-con

Photon energy dependent intensity variations observed in Auger spectra of free argon clusters

Photon energy dependent intensity variations are experimentally observed in the L2,3M2,3M2,3 Auger spectra of argon clusters. Two cluster sizes are examined in the present study. Extrinsic scattering effects, both elastic and inelastic, involving the photoelectron are discussed and suggested as the explanation of the variations in the Auger signal. The atoms in the first few coordination shells su