Allmänmedicin är ett brett område som spänner över många sjukdomstillstånd, med fokus på patientcentrering. Inom många områden sker en snabb kunskapsutveckling och rekommendationer för utrednings- och behandlingsstrategier uppdateras hela tiden. För en allmänläkare kan det vara svårt att hålla sig uppdaterad och tidsbrist begränsar möjligheterna att leta kunskap i det dagliga kliniska arbetet. Dig

Noradrenergic locus coeruleus (LC) efferents to the forebrain suppress seizures in several models of epilepsy. Using in situ hybridization, we demonstrate that tyrosine hydroxylase (TH) and norepinephrine transporter (NET) but not vesicular monoamine transporter 2 (VMAT2) mRNA levels are transiently elevated in LC neurons following kainic acid-induced status epilepticus. These increases of TH and

2015 was a year of an unprecedented migration from the Middle East to Europe. Sweden received almost 163,000 asylum applications. The civil society, including the former state church, took a notable responsibility. In a situation where the welfare systems are increasingly strained, and both the welfare state and the majority church are re-regulated, we ask: how does this play out in local contexts

The effects of altered N-methyl-D-aspartate (NMDA) receptor subunit composition on seizure development in kindling epilepsy were assessed in transgenic mice expressing high neuronal levels of NR2D under control of the calcium/calmodulin kinase II alpha subunit (αCaMKII) promoter. The NR2D subunit is normally present at very low levels in the mature forebrain. Transgenic mice showed a marked reduct

The effects of changing NMDA receptor subunit composition on synaptic plasticity in the hippocampus were analyzed by creating transgenic mice overexpressing NR2D, a predominantly embryonic NMDA receptor subunit. NMDA-evoked currents in the transgenic mice had smaller amplitudes and slower kinetics. The transgenics also displayed age-dependent deficits in synaptic plasticity in area CA1 of the hipp

Formation of metal hydrides is a serious complication that occur when hydride forming metals such as zirconium, niobium, vanadium and magnesium are exposed to long term hydrogen environment. The main concern is that the hydride, as being a brittle material, has very poor fracture mechanical properties. Formation of hydride is associated with transportation of hydrogen along the gradients of increa

The electronic structure of monolayer hexagonal boron nitride grown on Ni by the diffusion and precipitation method was studied by x-ray absorption spectroscopy, emission spectroscopy, x-ray photoelectron spectroscopy and micro-ultraviolet photoemission spectroscopy. No indication of hybridization between h-BN π and Ni 3d orbitals was observed. That is, the monolayer h-BN was found to be in the qu

We have constructed a compact soft X-ray emission spectrometer at the BL-09A beamline of the NewSUBARU synchrotron radiation facility at the University of Hyogo, Japan. Using this spectrometer, we observed a large take-off angle dependence of C-K emissions in highly oriented pyrolytic graphite (HOPG). At an excitation photon energy of 310 eV, far from the absorption edge of HOPG, we detected large

Knowledge of hydrogen bonds is important in a wide range of scientific fields. However, information on the electronic state of hydrogen bonded molecules in liquids and solutions is still limited. We applied X-ray emission and absorption spectroscopy to observe the electronic state around oxygen of water and investigate the solvent dependence of occupied and unoccupied valence electronic states of

Dissolved organic carbon (DOC) plays a key role in linking terrestrial and aquatic carbon cycles. Most of the work on soil and water DOC has been conducted in temperate watersheds. There is still a gap in knowledge on DOC dynamics within the tropics. This study assesses water extractable organic carbon (WEOC) in topsoils and describes the relationship between WEOC and land use/land cover (LULC), s

This article explores the genesis of the diplomatic law of international organizations in science and the doctrine of international law of Uzbekistan. The theoretical principles and the legal content of the diplomatic law of international organizations are learned. The inter-branch nature of the diplomatic law of international organizations as the sub-branch of law is disclosed.

ObjectiveTo describe the development of a computer-based risk assessment method for visual ergonomics, and assess its face validity, content validity, and internal consistency.MethodsThe risk assessment method contained a questionnaire for the worker, an evaluation form for the evaluator, a section of follow-up questions based on the worker's responses, and a section for recommended changes, inclu

Optimized biogenic carbon fluxes for Europe wereestimated from high-resolution regional-scale inversions, uti-lizing atmospheric CO2measurements at 16 stations for theyear 2007. Additional sensitivity tests with different data-driven error structures were performed. As the atmosphericnetwork is rather sparse and consequently contains large spa-tial gaps, we use a priori biospheric fluxes to furthe

Sweden and other developed countries are putting deliberate efforts into eHealth and digitalization of home care nursing. eHealth services have big potential in this area because they can provide mobile access to healthcare information. This study explores the eHealth services that home care nursing providers in Sweden currently use, plan to use, and have discarded. It also investigates their eHea

In order to move towards advanced 1-D models for secondary settling a more thorough understanding of compression is necessary. The inability of the current modelling frameworks to capture the variability in the compression phenomenon indicates that there is still something missing in the expression describing compressive settling. This can potentially be attributed to phenomena such as variations

OBJECTIVES: The influence of the amount and rate of weight loss on subsequently regaining weight and dropout from treatment in severely obese patients targeting 5% weight loss was investigated.METHODS: A total of 120 consecutive hospital patients with severe obesity (BMI: 42 ± 9 kg/m(2) ) participated in an inpatient program targeting 5% weight loss that involved goal setting, charting weight four