Comparative proteomic analysis of adult LMPPs and leukemic cells under stimulation of IFNa
Background and objectives: Acute myeloid leukemia (AML) is the most common type of leukemia in adults with relatively high recurrence. Interferon alpha (IFNa) is a type I interferon and it has been shown to have a therapeutic effect on myeloid malignancies in clinical research especially to prevent potentially risky AML recurrence after chemotherapy. Due to the molecular heterogeneity of the disea