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Head-up tilt test (TT) has been used for >50 years to study heart rate/blood pressure adaptation to positional changes, to model responses to haemorrhage, to assess orthostatic hypotension, and to evaluate haemodynamic and neuroendocrine responses in congestive heart failure, autonomic dysfunction, and hypertension. During these studies, some subjects experienced syncope due to vasovagal reflex. A
BACKGROUND: Nosocomial outbreaks of coronavirus disease 2019 (COVID-19) can have devastating consequences from both a resource cost and patient healthcare perspective. Relying on reverse transcription-polymerase chain reaction (RT-PCR) for identifying infected individuals may result in missed cases. Screening for antibodies after an outbreak can help to find missed cases and better illuminate rout
Rationale: Untreated obstructive sleep apnea (OSA) is associated with adverse outcomes in patients with coronary artery disease (CAD). Continuous positive airway pressure (CPAP) is the most common treatment, but despite interventions addressing established adherence determinants, CPAP use remains poor. Objectives: To determine whether physiological traits that cause OSA are associated with long-te
Colorectal cancer (CRC) is the third most prevalent cancer worldwide causing an estimated 700 000 deaths annually. Different types of treatment are available for patients with advanced metastatic colorectal cancer, including targeted biological agents, such as cetuximab, a monoclonal antibody that targets EGFR. We have previously reported a study indicating multiple levels of interaction between m
Glycerol levels in adipocytes depend on the lipolysis, the hydrolysis of triglycerides into glycerol and free fatty acids, and the efflux of glycerol across the plasma membrane through glycerol channels. The aims of this work were to investigate how glycerol levels are regulated on a molecular level by PLIN1, a major lipid droplet-associated protein and a key regulator of the lipolysis by scaffold
□ Total hip arthroplasty (THA) registers are established in several countries to collect data aiming to improve the results after THA. Monitoring of adverse outcomes after THA has focused mainly on revision surgery, but patientreported outcomes have also been investigated. □ Several surgery-related factors influencing the survival of the THA have been thoroughly investigated and have changed clini
The reduction of public expenditure and investments in health care provisioning calls for new, sustainable models to transform the increasing aging population and dementia-related diseases incidence from global challenges into new opportunities. In this context, Information and Communication Technologies play a vital role, to both promote aging in place and home management of Patients with Dementi
Background: Historically, endocrine therapy was used in a range of scenarios in patients with rising PSA, both as a treatment for locally advanced non-metastatic prostate cancer and PSA recurrence following curative intended therapy. In the present study the objective was to investigate if chemotherapy added to endocrine therapy could improve progression-free survival (PFS). Materials and Methods:
We present the CarbonTracker Europe High-Resolution (CTE-HR) system that estimates carbon dioxide (CO2) exchange over Europe at high resolution (0.1 × 0.2° ) and in near real time (about 2 months' latency). It includes a dynamic anthropogenic emission model, which uses easily available statistics on economic activity, energy use, and weather to generate anthropogenic emissions with dynamic time pr
The Andes mountains extend north–south in a latitudinal gradient of 8500 km. Because of the great climatic variety and the peculiar north–south orographic distribution, lakes are highly diverse, including different lake origins and contrasting morphometries. We reviewed >700 ecological studies on Andean lakes to identify the main threats to these freshwater systems. The most important threats are
Objectives: Studies supporting therapeutic drug monitoring to biopharmaceuticals in SLE are scarce. We aimed to assess anti-drug antibody (ADA) occurrence in belimumab-treated SLE patients and associations between belimumab concentrations and clinical response, serological outcomes and adverse events. Methods. We included 100 patients treated with intravenous belimumab. Clinical data and biologica
Popular Abstract in Swedish Avhandlingen handlar om två städer - Malmö i Sverige och Kapstaden i Sydafrika - och om några speciella platser i dessa städer. Det handlar om stadsdelarna Möllevången och Woodstock strax utanför respektive städers centrum, och gatan Long Street som är beläget i själva Kapstadens hjärta. Det är platser som ingår i olika historiska och politiska sammanhang, där MöllevångThe dissertation is an ethnographic study focusing on two cities, Malmö in Sweden and Cape Town in South Africa. More specifically it focuses on three areas; the neighbourhoods Möllevången and Woodstock close to the respective city centres, and the street Long Street in the very heart of Cape Town central business district. These places belong to different historical and political contexts. Möllev
Background: Only few studies have compared environmental pesticide air concentrations with specific urinary metabolites to evaluate pathways of exposure. Therefore, we compared pyrimethanil and chlorpyrifos concentrations in air with urinary 4-hydroxypyrimethanil (OHP, metabolite of pyrimethanil) and 3,5,6-trichloro-2-pyridinol (TCPy, metabolite of chlorpyrifos) among pregnant women from the Infan
OBJECTIVES: This research evaluates whether environmental exposures (pesticides and smoke) influence respiratory and allergic outcomes in women living in a tropical, agricultural environment. METHODS: We used data from 266 mothers from the Infants' Environmental Health cohort study in Costa Rica. We evaluated environmental exposures in women by measuring seven pesticide and two polycyclic aromatic
Acute myeloid leukemia (AML) arises when leukemia-initiating cells, defined by a primary genetic lesion, acquire subsequent molecular changes whose cumulative effects bypass tumor suppression. The changes that underlie AML pathogenesis not only provide insights into the biology of transformation but also reveal novel therapeutic opportunities. However, backtracking these events in transformed huma
Context: The low quality and small size of samples in empirical studies in software engineering hamper the interpretation and generalization of their results. Therefore, enlarging sample sizes and improving their quality represent an important research challenge. Goal: We aim to define a conceptual framework, including requirements for establishing adequate sources for sampling subjects in softwar
Context. The formation of globular clusters remains an open debate. Dwarf starburst galaxies are efficient at forming young massive clusters with similar masses as globular clusters and may hold the key to understanding their formation. Aims. We study star cluster formation in a tidal debris, including the vicinity of three tidal dwarf galaxies, in a massive gas-dominated collisional ring around N
