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To determine the spectrum of secreted proteins that are present in the extracellular space of early Xenopus embryos, a direct secretion screen was performed. Surprisingly, 24% of previously identified bona fide secretory proteins corresponded to four secreted Wnt antagonists of the same family: frzb-1, sizzled, sfrp-2 and crescent. sfrp-2 and crescent are novel components of the growing cocktail o

This study contributes to a growing stream of literature on servitization in management accounting. In extension to recent explorations in servitization and management accounting, this paper presents how KPIs in innovation reflect the shift towards servitization. The chosen methodology, participatory action design, gives a unique insight how organizations respond and construct KPIs (key performanc

that are influenced by use of management control systems (MCS). By means of a systematic literature review, the theoretical constructs are explored and related to part of the MCS, namely the performance measurement systems (PMS) and the business model of innovation (i.e. innovation input, process, output, and outcome). The results of the systematic literature review will be used to develop a set o

The optical klystron installed on the Elettra storage-ring is normally used as interaction region for an oscillator free-electron laser, but, removing the optical cavity and using an external seed laser, one obtains an effective scheme for single-pass harmonic generation. In this configuration the high-power external laser is synchronized with the electron beam entering the first undulator of the

In a storage-ring free-electron laser (FEL), the onset and growth of intra-cavity power at the resonator wavelength can be naturally accompanied by coherent emission at higher harmonics. Contrary to what happens in singlepass linac-based devices, the electron beam is re-circulated in the storage ring and, while the microbunching becomes "thermalized" from turn to turn, the evolution of other bunch

Defects in the synthesis pathways of amino acids have only been discovered in recent years and are relatively unknown to most clinicians. In this chapter disorders neurological symptoms caused by genetic defects in the synthesis of the amino acids serine, glutamine and proline are discussed. Patients with serine deficiency invariably suffer from severe neurological symptoms such as microcephaly, p

The paper presents a fermentation technique, which combines the advantages of the probing feeding strategy and the temperature limited fed-batch technique. The early phase of the cultivation is run under glucose limited conditions by using the original probing technique. When the maximum oxygen transfer capacity of the reactor is reached, the temperature is decreased to lower the oxygen demand. A

Abstract Habitat complexity is shown to be an important driver of invertebrate diversity on impacted coral reefs when the diversity supported by a comparative unit of habitat complexity is compared to that of a pristine coral reef. The more structurally complex pristine reef does not support the conventionally expected greatest amount of diversity, instead an upper limit threshold to habitat comp

Avian malaria parasites are prevalent all around the world and infect a wide diversity of bird species. In this report the prevalence of Plasmodium lineages in Spanish house sparrows was studied. According to previous research, higher variation of Plasmodium lineages could be expected in southern climates. This was tested by using samples collected from Spain and performing nested PCR with primers