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OBJECTIVES: To evaluate the systemic phenotype associated with the presence of isolated anti-La/SSB antibodies in a large international registry of patients with primary Sjögren's syndrome (pSS) fulfilling the 2002 classification criteria.METHODS: The Big Data Sjögren Project Consortium is an international, multicentre registry created in 2014. Baseline clinical information from leading centres on
Global impact models represent process-level understanding of how natural and human systems may be affected by climate change. Their projections are used in integrated assessments of climate change. Here we test, for the first time, systematically across many important systems, how well such impact models capture the impacts of extreme climate conditions. Using the 2003 European heat wave and drou
BACKGROUND: Single nucleotide polymorphisms (SNPs) rs429358 (ε4) and rs7412 (ε2), both invoking changes in the amino-acid sequence of the apolipoprotein E (APOE) gene, have previously been tested for association with multiple sclerosis (MS) risk. However, none of these studies was sufficiently powered to detect modest effect sizes at acceptable type-I error rates. As both SNPs are only imperfectly
CONTEXT: Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. However, there are no large-scale studies looking at the genetic determinants of beta-cell glucose sensitivity. OBJECTIVE: To understand the genetic determinants of pancreatic beta-cell gluc
Objective: To develop and validate Clinical Diversity In Meta-analyses (CDIM), a new tool for assessing clinical diversity between trials in meta-analyses of interventions. Study design and setting: The development of CDIM was based on consensus work informed by empirical literature and expertise. We drafted the CDIM tool, refined it, and validated CDIM for interrater scale reliability and agreeme
Mycorrhizal fungi are mutualists that play crucial roles in nutrient acquisition in terrestrial ecosystems. Mycorrhizal symbioses arose repeatedly across multiple lineages of Mucoromycotina, Ascomycota, and Basidiomycota. Considerable variation exists in the capacity of mycorrhizal fungi to acquire carbon from soil organic matter. Here, we present a combined analysis of 135 fungal genomes from 73
BACKGROUND: Platelet transfusions are frequently used in the intensive care unit (ICU), but current practices including used product types, volumes, doses and effects are unknown.STUDY DESIGN AND METHODS: Sub-study of the inception cohort study 'Thrombocytopenia and Platelet Transfusions in the ICU (PLOT-ICU)', including acutely admitted, adult ICU patients with thrombocytopenia (platelet count <1
In the context of biomedical researchinvolving human subjects, the reviewof research proposals by ethics committeesin virtually every country hastraditionally focused on informed consentand other protections for individualsparticipating in research (1). However,the substantial societal implications ofmodern biomedical research and the globalizationof scientific inquiry make it importantto understa
Background: Antipsychotic medication is effective for symptomatic treatment in schizophrenia-spectrum disorders. After symptom remission, continuation of antipsychotic treatment is associated with lower relapse rates and lower symptom severity compared to dose reduction/discontinuation. Therefore, most guidelines recommend continuation of treatment with antipsychotic medication for at least 1 year
Two of the key functions of arteries in the brain are (1) the well-recognized supply of blood via the vascular lumen and (2) the emerging role for the arterial walls as routes for the elimination of interstitial fluid (ISF) and soluble metabolites, such as amyloid beta (Aβ), from the brain and retina. As the brain and retina possess no conventional lymphatic vessels, fluid drainage toward peripher
Background: Survivors of Hodgkin lymphoma (HL) are at risk of developing non-Hodgkin lymphoma (NHL) after treatment; however, the risks of developing subsequent primary lymphomas (SPLs), including HL and NHL, after different types of childhood cancer are unknown. The authors quantified the risk of SPLs using the largest cohort of childhood cancer survivors worldwide. Methods: The Pan-European Netw
Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults worldwide. Although genome-wide association studies (GWAS) have uncovered the germline genetic component underlying CLL susceptibility, the potential use of GWAS-identified risk variants to predict disease progression and patient survival remains unexplored. Here, we evaluated whether 41 GWAS-identified risk variants for C
Agricultural intensification and associated loss of high-quality habitats are key drivers of insect pollinator declines. With the aim of decreasing the environmental impact of agriculture, the 2014 EU Common Agricultural Policy (CAP) defined a set of habitat and landscape features (Ecological Focus Areas: EFAs) farmers could select from as a requirement to receive basic farm payments. To inform th
Background: Pediatric asthma remains a public health challenge with enormous impact worldwide. Objective: The aim of this study was to identify and prioritize unmet clinical needs in pediatric asthma, which could be used to guide future research and policy activities. Methods: We first identified unmet needs through an open-question survey administered to international experts in pediatric asthma
Prostate Cancer Diagnosis and Treatment Enhancement Through the Power of Big Data in Europe (PIONEER) is a European network of excellence for big data in prostate cancer, consisting of 32 private and public stakeholders from 9 countries across Europe. Launched by the Innovative Medicines Initiative 2 and part of the Big Data for Better Outcomes Programme (BD4BO), the overarching goal of PIONEER is
Universitetsbibliotekets årsberättelse 2024 1 Universitetsbibliotekets årsberättelse 2024 LUNDS UNIVERSITET 2 Innehåll Skörd och sådd ................................................................................................................ 3 MER ÖPPEN VETENSKAP .............................................................................................. 4 Bibliometri, ranking och öppen vet
https://www.ub.lu.se/sites/ub.lu.se/files/2025-03/arsberattelse-2024.pdf - 2026-06-27
Abstract Environmentally Attributable Cancers in Washington State, US: Applying Economic Cost Estimates and the Precautionary Principle A thesis submitted in partial fulfillment of the requirements of Lund University International Master's Programme in Environmental Science Lund University, Sweden 22 November 2004 R. Dietrich Hauge 275 W. Roy St. #311, Seattle, WA 98119, United States deehauge@hot
https://www.lumes.lu.se/sites/lumes.lu.se/files/hauge_dietrich.pdf - 2026-06-27
Microsoft Word - Radslans_geografi_ver4 JF_test1_EF.docx #17 SÄKERT! Upplevd trygghet på svenska besöksmål EN RAPPORT FRÅN2021 2 / S Ä K E R T ! – U P P L E V D T R Y G G H E T P Å S V E N S K A B E S Ö K S M Å L 3 5 7 10 15 24 29 INNEHÅLLSFÖRTECKNING 1/ INLEDNING 2/ SLUTSATSER 3/ FORSKARNAS REKOMMENDATIONER 4/ ”KEEP CALM AND CARRY ON” 5/ TRE RÖSTER OM SÄKRA DESTINATIONER 6/ OM FORSKNINGSPROJEKTET
https://www.isk.lu.se/sites/isk.lu.se/files/2021-03/BFUF_17_Sakert_20210318.pdf - 2026-06-27
1 Teaterhögskolan i Malmö: Självvärdering 2018 1. Inledning .................................................................................................................................. 3 1.1 Utbildning på grundnivå: särskilda förutsättningar ...................................................................... 6 1.1.1 Metodik .................................................................
https://www.konstnarliga.lu.se/sites/konstnarliga.lu.se/files/2020-12/Binder_thm_2018.pdf - 2026-06-27
LUM nr 6 - 2004 - - - - - - - - - - - - - - - - ”Öppenheten Kan datorn bli måste öka” som hjärnan? L U N D S U N I V E R S I T E T M E D D E L A R N U M M E R 6 J U N I 2 0 0 4 Å R G Å N G 3 7 Homo academicus Homo academicus –– så funkar detså funkar det I II - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Lunds universitets tidskrift LUM utkom första gången 1968. Den når i dag samtl
https://www.lu.se/sites/www.lu.se/files/lunds-universitets-magasin-6-2004.pdf - 2026-06-27
