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Longitudinal functional connectivity during rest and task is differentially related to Alzheimer’s pathology and episodic memory in older adults
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"Den passiva majoriteten" – en nyckel till varaktig förändring
Prevention and Management of Bleeding Episodes in Children with Hemophilia
Regular prophylactic treatment with factor VIII (FVIII) and factor IX (FIX) concentrates in hemophilia A and B, respectively, is introduced in early infancy and has resulted in dramatic improvement of the conditions. Recombinant FVIII and FIX concentrates have been available for > 25 years and have been modified and refined through the years; however, unfortunately frequent intravenous administrat
Kvinnan från Barum – från äldre stenåldern : En forskningshistorik samt därtill några ställningstaganden och tillrättalägganden, kritiska anmärkningar och slutsatser.
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A comparison of different orthogonal techniques for the investigation of the conformational stability of NIST mAb in liquid formulations
Antikroppar har ett brett användningsområde med stor potential men det är svårt att skapa stabila lösningar. Den strukturella stabiliteten är en viktig faktor när man väljer läkemedelskandidater, och i de tidiga utvecklingsstadierna görs prediktiva undersökningar för att ta reda på varje kandidats stabilitet och utvecklings-potential. Därmed är det av största intresse att utvärdera hur antikropparA great challenge during early development of medicinal antibodies is to determine the stability of the candidates. This is required to be able to select the candidates with the greatest developability. The stability of the candidates can be estimated using different orthogonal techniques and the aim of this investigation was thus to use orthogonal techniques for the investigation of conformationa
Effects of chronic citalopram treatment on central and peripheral spontaneous open-field behaviours in rats
The spontaneous open-field behavioural effects of 10 days of chronic treatment with two clinical doses (10 and 20 mg/kg daily) and one high/toxic dose (100 mg/kg daily) of the selective serotonin reuptake inhibitor citalopram (delivered subcutaneously by implanted osmotic pumps) were examined in rats. Central and peripheral arena locomotor and rearing activities were recorded simultaneously, and t
Electrocatalytic proton reduction by thiolate-capped triiron clusters [Fe3(CO)9(μ3-SR)(μ-H)] (R = iPr, tBu)
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Selection on the joint actions of pairs leads to divergent adaptation and coadaptation of care-giving parents during pre-hatching care
The joint actions of animals in partnerships or social groups evolve under both natural selection from the wider environment and social selection imposed by other members of the pair or group. We used experimental evolution to investigate how jointly expressed actions evolve upon exposure to a new environmental challenge. Our work focused on the evolution of carrion nest preparation by pairs of bu
Dissecting Lewis score under the light of fecal calprotectin; an analysis of correlation of score components with calprotectin levels in capsule endoscopy.
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Reconstructing institutional stability and change Conceptualizing the social ontology of institutional stability and change in Historical Institutionalism
Questions about institutional stability and change are critically important for any understanding of political institutions. The field of Historical institutionalism in political science has described, studied and theorized institutions for decades. One of the most recurring concepts utilized in the explanation of institutional stability is path dependence, describing theoretical and empirical mec