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Aim/hypothesis: Human enteroviral infections are suggested to be associated with type 1 diabetes. However, the mechanism by which enteroviruses can trigger disease remains unknown. The present study aims to investigate the impact of enterovirus on autophagy, a cellular process that regulates beta cell homeostasis, using the clonal beta cell line INS(832/13) and human islet cells as in vitro models

This presentation gives an overview of a peer learning model and academic support intervention named SI-PASS (Supplemental Instruction – Peer Assisted Study Schemes) in Higher Education in Europe. SI-PASS is a method of improving student performance in “difficult”, normally introductory, courses combining “how to learn” with “what to learn”. SI-PASS sessions are scheduled parallel to the regular e

PURPOSE: To investigate the incidence and causes of visual impairment in children born prematurely in Finland from 1972 through 1989, and to determine what conditions and factors were associated with its occurrence. DESIGN: Retrospective, cross-sectional study. SUBJECTS: All visually impaired individuals from 0 to 17 years of age who had been born at fewer than 37 gestational weeks in Finland from

BackgroundA specific eHealth device, a surf tablet, was developed for bridging between advanced in-hospital care and children’s homes. Since little is known about determinators for parental eHealth usage, the study’s aim was to explore if parents’ usage of the device was associated with their eHealth literacy, or their satisfaction with their child’s healthcare or with the specific surf tablet.Met

Giant planets migrate though the protoplanetary disc as they grow their solid core and attract their gaseous envelope. Previously, we have studied the growth and migration of an isolated planet in an evolving disc. Here, we generalise such models to include the mutual gravitational interaction between a high number of growing planetary bodies. We have investigated how the formation of planetary s

Aim: The overall aim was to investigate associations between bullying, violence and mental health among young people in Sweden. Specific aims were to investigate differences in exposure to peer victimization among disabled and non-disabled adolescents (Paper I), the influence of social support on the relationship between cyber harassment and mental distress among adolescents (Paper II), the associ

In situ CO2 and CO measurements from five Integrated Carbon Observation System (ICOS) atmosphere stations have been analysed together with footprint model runs from the regional Stochastic Time-Inverted Lagrangian Transport (STILT) model to develop a dedicated strategy for flask sampling with an automated sampler. Flask sampling in ICOS has three different purposes, namely (1) to provide an indepe

Purpose: The aim of this study was to assess the suitability of Gafchromic EBT3 films for reference dose measurements in the beam of a prototype high dose-per-pulse linear accelerator (linac), capable of delivering electron beams with a mean dose-rate (Dm) ranging from 0.07 to 3000 Gy/s and a dose-rate in pulse (Dp) of up to 8 × 106 Gy/s. To do this, we evaluated the overall uncertainties in EBT3

Previous studies on lymphocytes have suggested that patients with head and neck squamous cell carcinoma (HNSCC) have an increased susceptibility for chromosomal damage induced by bleomycin, a known radiomimetic mutagen. However, it has so far not been possible to study whether this genetic instability is present also in the epithelial component of the upper aerodigestive tract mucosa, the tissue f

Popular Abstract in Swedish Ökad förståelse för hjärtats pumpfunktion är av stort intresse för att kunna förbättra diagnostik, behandling och prognoser för hjärtsjuka patienter. Blodflöde i hjärtat är direkt kopplat till hjärtats form och rörelse och kan därför vara en viktig markör för hjärtats funktion. Därför var målet med denna avhandling att utveckla och förbättra mätningar av blodflöde med hIncreased understanding of the pumping mechanics of the heart are of great importance to develop diagnostics, treatment and prognostics for cardiovascular diseases. Blood flow in the heart is connected to its anatomy and function, and may therefore be a sensitive marker of cardiac health and disease. Therefore, the aim of this thesis is to develop and validate methods for quantification and visual

Popular science summary: How do bacteria divide? Cell division is an absolute requirement for proliferation of all bacteria and results in the bacterium being split into two by a septum. FtsZ is a protein that plays a key role in bacterial cell division. In this project, one part of the FtsZ protein was investigated with genetic methods to understand how it affects the division process. Previou

Cooperation in soils can make a huge difference At a first glance, the coexistence of diverse plants in ecosystems seems to be completely harmonious. However, there is a high competence of these organisms for obtaining resources. In this scenario, most of the plants have decided to make a lifetime deal with fungi in order to ensure their development and survival. This symbiotic association is cal

Fire and grazing, a disaster or opportunity? Due to climate change, disturbances such as forest fires are expected to see an increase in frequency in the 21st century. Fires can increase species diversity since it can create habitats for early successional species. At least if it does not happen too often. Imagine living in a house that burns down every year, it would not be a very nice place to

Populärvetenskaplig sammanfattning: Förekomsten av finkorniga granitgångar är ett potentiellt problem vid lagring av kärnbränsle i berggrunden eftersom de utgör svaghetszoner. Det är därför viktigt att ta reda på hur dessa gångar beter sig i berggrunden. Huvudsyftet med detta examensarbete är att undersöka om de finkorniga granitgångarna är kontrollerade av några strukturer i tunneln vid ÄspölaborThe occurrence of fine-grained granite (FGG) dykes is one of the potential problems in the storage of nuclear waste in the bedrock. It is therefore important to locate and characterise such dykes. The major object in this thesis is to investigate, whether the FGG dykes at the Äspö Hard Rock Laboratory (ÄHRL) are structurally controlled. This involves measuring the orientations of the dykes, to cor

Produkter framställda från massa är en del av vardagen. Med produkter så som kaffefilter, förpackningar till mat och mjukpapper. Dessa är ett resultat av trä som behandlats i massabruk för att producera massa, som de tidigare nämnda pappersprodukterna är producerade från. Den moderna pappers och massaindustrin är energiintensiv och står för stora utsläpp utifrån ett globalt perspektiv, ansvarig föProducts made from pulp are a part of everyday life. With end products like coffee filters, food packaging and tissue paper. These products are the result of wood being processed in pulp mills to produce the pulp from which the forementioned paper products are produced. The modern pulp and paper industry is energy intense and on a global perspective a large emitter of greenhouse gasses, accounting

Skadliga marina arter invaderar idag främmande habitat och ekosystem med en extrem hastighet. Dessa arter har haft en mycket stor negativ inverkan på många sårbara ekosystem runt om i världen och barlastvatten har identifierats som en av de största faktorerna bakom den snabba spridningen. Idag är den vanligaste åtgärden för att lösa problemet att byta barlastvatten ute till havs för att göra sig aHarmful aquatic species are today invading foreign habitats at an unprecedented pace. They have had a large negative impact on many fragile ecosystems of the world and ballast water has been identified as one the major culprits behind their fast spread. Today, the most common remedy used to combat the problem is exchanging ballast water in the open ocean to get rid of any organisms with the potent

Popular science summary Are drugs only drugs for human being? An experiment to see if some of the anthropogenic pharmaceuticals are toxic contaminants for the aquatic environment. All kinds of pharmaceuticals have been using widely and the amount has been increased significantly during the last few decades. Concerns about the occurrence of pharmaceuticals releasing into different matrixes of th

Denna uppsats baserar sig på en utredning av Försäkringskassan, som presenterades i maj 2005. Titeln var Utredning om könsneutralt och delat barnbidrag. Försäkringskassan hade fått i uppdrag av regeringen att utreda förutsättningarna för att göra lagstiftningen kring barnbidraget könsneutral och införa en möjlighet för föräldrarna att kunna dela bidraget mellan sig. Den nuvarande barnbidragslagsti

In this project the aim was to design a concrete 3d printer. This report focuses on the extruder part of the printer and the printing material. The basic principle of 3d printing is that it is an additive manufacturing technique, on the contrary to the traditional subtractive manufacturing techniques. The potential benefits of concrete 3d printing compared to the techniques that are used today are