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Objective: To identify and quantify potential risk factors for osteoarthritis (OA) following traumatic knee injury. Design: Systematic review and meta-analyses that estimated the odds of OA for individual risk factors assessed in more than four studies using random-effects models. Remaining risk factors underwent semiquantitative synthesis. The modified GRADE (Grading of Recommendations Assessment

The action of three matrix metalloproteinases (MMPs), 72- and 95-kDa gelatinases (MMP-2 and MMP-9) and PUMP (MMP-7), and a cysteine proteinase, cathepsin B, were investigated on aggrecan the major proteoglycan of cartilage. All the enzymes cleaved aggrecan although the activity of the 95-kDa gelatinase was very low. Specific cleavage sites were investigated following incubation with a purified agg

The abuse of flunitrazepam (FZ) compounds is worldwide, and several studies have reflected on the consequences with regard to violence, aggression and criminal lifestyle of FZ users. Criminals take high doses of FZ or some other benzodiazepines to "calm down" before the planned crime. There is support from earlier studies that most likely, all benzodiazepines may increase aggression in vulnerable

Stroke and in this case cerebral infarction affects 20 million people each year and five million of them die. In Sweden 30-35000 people will be affected and one of three of them will be severely disabled. In addition, one of six will suffer a new stroke within six years. The cause of stroke is usually a vessel in the brain that is blocked, resulting in massive neuronal cell death. Since treatment

Nutrient uptake by forest trees is dependent on ectomycorrhizal (EM) mycelia that grow out into the soil from the mycorrhizal root tips. We estimated the production of EM mycelia in root free samples of pure spruce and mixed spruce-oak stands in southern Sweden as mycelia grown into sand-filled mesh bags placed at three different soil depths (0-10, 10-20 and 20-30 cm). The mesh bags were collected

The present thesis concerns middle-aged women’s subjective well-being (SWB). The interest is focused on the importance of childhood factors, social circumstances, and personality for middle-aged women’s general SWB. Data were taken from the longitudinal research program Individual Development and Adaptation (IDA, Magnusson & Bergman, 2000) and concerned a sample of about 300 women. The main an

The therapeutic management of Sjögren syndrome (SjS) has not changed substantially in recent decades: treatment decisions remain challenging in clinical practice, without a specific therapeutic target beyond the relief of symptoms as the most important goal. In view of this scenario, the European League Against Rheumatism (EULAR) promoted and supported an international collaborative study (EULAR S

Background Multiple myeloma cells uniformly overexpress CD38. We studied daratumumab, a CD38-targeting, human IgG1κ monoclonal antibody, in a phase 1-2 trial involving patients with relapsed myeloma or relapsed myeloma that was refractory to two or more prior lines of therapy. Methods In part 1, the dose-escalation phase, we administered daratumumab at doses of 0.005 to 24 mg per kilogram of body

Context. Observational evidence indicates that the orbits of extrasolar planets are more various than the circular and coplanar ones of the solar system. Planet-planet interactions during migration in the protoplanetary disc have been invoked to explain the formation of these eccentric and inclined orbits. However, our companion paper (Paper I) on the planet-disc interactions of highly inclined an

Soft x-ray emission spectroscopy is a common tool for the study of the electronic structure of molecules and solids. However, the interpretation of spectra is sometimes made difficult by overlaying lines due to satellite transitions or close-lying core holes. Also, irrelevant inner core transitions may accidentally fall in the wavelength region under study. These problems, which often arise for sp

Background: T1D and AITD are autoimmune disorders commonly occurring in the same family and even in the same individual. The genetic contribution to these disorders is complex making uncovering of susceptibility genes very challenging. The general aim of this study was to identify loci and genes contributing to T1D/AITD susceptibility. Our strategy was to perform linkage and association studies in

I denna rapport redovisas populationstrender för 224 svenska fågelarter för olika långa tidsperioder, samt korttidstrender för 12 arter av större däggdjur. Fåglarna har räknats höst, vinter, vår och sommar enligt strikt standardiserade metoder. Sommar- respektive vinterpunktrutter har räknats sedan 1975, i huvudsak i södra Sverige. Standardrutterna räknas också på sommaren (sedan 1996)men täcker hWe present the results of the Swedish Bird Survey, a project run by the Department of Biology, Lund University, as a part of the National Monitoring Programme of the Swedish Environmental Protection Agency. The results for 2022 include data from: 546 winter point counts in 2021/2022 (47th winter), ofwhich 254 were carried out during the Christmas/New Year count, 209 summer point count routes (48th

STUDY QUESTION: Do serum levels of anti-Müllerian hormone (AMH) change in women of reproductive age following dietary and surgery-induced weight loss?SUMMARY ANSWER: AMH levels increased after very low-calorie diet (VLCD) before surgery and decreased at 6 and 12 months after Roux-en-Y gastric bypass (RYGB), beyond expected normal age-related decline.WHAT IS KNOWN ALREADY: Obesity has negative effe

Purpose: To evaluate: (i) the relationship between intraocular pressure (IOP) reduction attained with a fixed treatment protocol and the untreated IOP level; (ii) the consistency of IOP reduction over time; and (iii) whether there is a threshold pretreatment IOP level below which IOP reduction might be less effective. Results are based on 128 patients with glaucoma with field defects, who were ran

Lantmännen Lantbruk har i ett projekt tillsammans med Lunds Tekniska Högskola utvecklat en modell för analys av vattenhalt i svenskodlad raps med tekniken Fourier Transform Nära Infraröd (FT-NIR). Kvaliteten i de mätvärden som modellen levererar är mycket lik kvaliteten i den metodik (referensmetodik) som försökte efterliknas när modellen skapades. Även ur ett internationellt perspektiv presterar A FT-NIR (Fourier-Transform Near Infrared) model for moisture content has been developed for whole seeds of Swedish rapeseed (Brassica napus) by the conditions given during the harvest of 2014. Compared to Internal standardized (ISO) method 665, the final model showed very small differences in terms of repeatability and measurement uncertainty even though the measurement time was four times faster

Det råder idag en trend att förtäta, det vill säga bygga tätt i städer istället för att låta städer växa utåt. Det finns många fördelar med att förtäta då en tät stad ger underlag för bättre service och tätare kollektivtrafik vilket därmed kan leda till mer hållbara städer. Men det finns också nackdelar med att bygga tätt. Genom att förtäta städer samlas fler människor på mindre ytor och därmed ocToday it has become a trend to densify cities instead of allowing them to grow outwards. Densification has many advantages, a dense city provides a basis for better service and denser public transport, which can lead to more sustainable cities. However, building dense also has its disadvantages. By densifying cities, more people gather on a smaller area. This result in more children on a smaller a

The aim of this study was to model the impacts of climate change on potential geographical distribution of Prunus africana in the Eastern Arc Mountains of Tanzania. Maximum Entropy modelling was used to construct species distribution maps for P. africana to determine relative contribution, and effects of climate change on the potential geographical distribution of P. africana based on climatic sce

Amazing scissors or revolutionizing treatments? Autoimmune diseases, cancer and allergies are something that is on the rise in the Western world and can cause major problems in everyday life, in the worst case even death. In addition to that, we have a growing problem with antibiotic-resistant bacteria and increased complications for both healthy people, and especially for those who already have

Background: Treatment decisions can be difficult in men with low-risk prostate cancer (PCa). Objective: To evaluate the ability of a panel of four kallikrein markers in blood-total prostate-specific antigen (PSA), free PSA, intact PSA, and kallikrein-related peptidase 2-to distinguish between pathologically insignificant and aggressive disease on pathologic examination of radical prostatectomy (RP

Anställningsförhållandet grundas på ett personligt förhållande och präglas av ett starkt behov av förtroende. I bestående anställningsavtal skall arbetstagaren i stort sett sätta arbetsgivarens intresse framför sitt eget. Vilken skyldighet har emellertid arbetstagare att iaktta arbetsgivarens intresse vid ingående av anställningsavtalet? Syftet med denna uppsats har varit att utreda i vilken utstrWhen entering into a contract it is important to maintain a certain grade of honesty and loyalty. Not only is it wrong to deceive a party in order to reach a beneficial agreement, it is in certain cases also contrary to good faith and fair dealing to leave a mistaken party in error. The law therefore imposes a duty of disclosure that requires a party to reveal all matters known, in its entirety, t