Filtyp
In this work we have investigated the structures of aggregates formed in model systems of dilute aqueous mixtures of "model chromatin" consisting of either recombinant nucleosome core particles (NCPs) or nucleosome arrays consisting of 12 NCPs connected with 30 bp linker DNA, and liposomes made from different mixtures of cationic and zwitterionic lipids, 1,2-dioleoyl-3-trimethylammonium-propane ch
Aims: During recent years, two strategies of incretin-based therapy [glucagon-like peptide-1 (GLP-1) receptor agonism and dipeptidyl peptidase-4 (DPP-4) inhibition] have entered the market for pharmacological management of type 2 diabetes. A main indication for this therapy is as add-on to on-going metformin therapy in subjects with type 2 diabetes who have insufficient glycaemic control with metf
Popular Abstract in Swedish Knäartros är en mycket vanlig sjukdom som leder till successiv nedbrytning och förlust av brosket i leden, en process som oftast tar 10-20 år. Detta orsakar svår smärta och stelhet och i dag saknas botande behandling mot artros. Det är dock rimligt att anta att en behandling har bättre förutsättningar att lyckas ju tidigare den sätts in. Man vet att det tidigt under sjuDelayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is a new technique to study cartilage glycosaminoglycan (GAG) content. The negatively charged contrast agent Gd-DTPA2-, injected intravenously, distributes in the cartilage inversely to the likewise negatively charged GAG. The GAG concentration is reflected by the MRI parameter T1 and the Gd-DTPA2- concentration by the MRI parameter R1 (R1=1/T
Organization theory and management studies tend to underrate the importance of material and technological resources in accomplishing organized activities. Given the pervasive influence of technology in everyday life in organizations, surprisingly little attention is paid to the entanglement of technologies and practices of organizing. In organizations, a wide variety of technologies, ranging from
Popular Abstract in Swedish Avhandlingen utforskar vad det innebär att vara verksamhetsnära chef i en svensk kommunal omsorgsorganisation. Det forskningsprojekt som utgör avhandlings empiriska bas tillkom för att de medverkande cheferna upplevde att de hade en svår arbetssituation. Resultaten från projektet belyser chefskapets innebörd och förutsättningar, sett ur chefernas perspektiv. Det allra The present doctoral thesis aimed to explore what it means to be a first-level manages in a Swedish municipal social care administration, seen from the managers’ perspective. The empirical data derives from a participative, constructivist project which intended to contribute to new practice-based knowledge and to the learning and development of the participating managers. The participating manager
It is important to provide scientific knowledge of wheelchairs as occupant-protecting seats in motor vehicles. This study aimed at examining the situation in Special Transportation Services (STS), an important mode of transport for wheelchair users in Sweden. The perceived safety levels were assessed and examined, and extensive field experience was gained. During the study in three Swedish cities
With the exponential growth of the World Wide Web, automated subject classification of Web pages has become a major research issue in information and computer sciences. Organizing Web pages into a hierarchical structure for subject browsing is gaining more recognition as an important tool in information-seeking processes. In this thesis, different automated classification approaches, focusing on
Laparoscopic surgery was introduced to minimize patient trauma. However, fatal technique specific complications, due to major vascular or visceral injury, were at times seen related to blind abdominal access using the Veress technique. A modified open access technique was developed and evaluated in 100 patients and found to be fast and easy to learn with few associated complications. This open te
The colorimetric 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay was standardized for direct detection of rifampin-resistant Mycobacterium tuberculosis in sputum samples. The sensitivity and specificity of the direct MTT assay matched those of the standard indirect susceptibility assay on 7H10 medium, and interpretable results were obtained for 98.5% of the samples within
The interest for the design of life environments for persons with dementia is growing stronger among architects, engineers, social scientists and those responsible for housing and health care planning. This development is connected to the enlarged group of people that become afflicted by this disease and to the fact that a safe environment is proved to be very important for their well-being as wel
A new, cyclodextrin glycosyltransferase (CGTase) from an alkaliphilic B. agaradhaerens strain LS-3C, isolated front an Ethiopian soda lake. was purified up to 43-fold by starch adsorption with a yield of 50%. The enzyme was a monomer with an estimated molecular weight of 110 kDa, representing the largest Bacillus CGTase reported so far. The isoelectric point (pI) of the enzyme was 6.9. The CGTase
The question of whether very weak low frequency magnetic fields can affect biological systems, has attracted attention by many research groups for quite some time. Still, today, the theoretical possibility of such an interaction is often questioned and the site of interaction in the cell is unknown. In the present study, the influence of extremely low frequency (ELF) magnetic fields on the transpo
OBJECTIVE: To evaluate the activity of benzydamine, lidocaine, and bupivacaine, three drugs with local anesthetic activity, against Candida albicans and non-albicans strains and to clarify their mechanism of activity. METHODS: The minimal inhibitory concentration (MIC) was determined for 20 Candida strains (18 clinical isolates and two American Type Culture Collection strains). The fungistatic act
Behaviour management problems (BMP) are common among children (4-12%) and the prevalence seems to be rising. Persistent antisocial behaviour often leads to poor long-term psychosocial adjustment. Structured parent-training programmes have proven to be the most effective way of treating BMP in young children. The Incredible Years Series (IYS), which is a manual-based programme, was introduced in Sw
Many separate-sexed organisms have sex chromosomes controlling sex determination. Sex chromosomes often have reduced recombination, specialized (frequently sex-specific) gene content, dosage compensation and heteromorphic size. Research on sex determination and sex chromosome evolution has increased over the past decade and is today a very active field. However, some areas within the field have no
In recent years, newly arrived students have been in focus in Swedish education, for example, because of the large number of asylum seekers to Sweden which has become a challenge for the Swedish school system (Swedish Schools Inspectorate, 2015). But also because of recent changes in the Education act whereby time spent in reception classes was to be reduced for newly arrived students and they sha
Learning is often a central element of tourism. Tourists can learn actively, i.e. with a specific purpose, as well as passively through the comparison of values, norms and customs. It has been argued that travel supports active learning that has positive outcomes for sustainability, for instance, in the context of conservation. Yet, the complexity of active and passive learning processes and their
The objective of the study was to examine the changes in central nervous system (CNS) activity and physical behaviour during induction and awakening from CO2 anaesthesia. Two studies, each using pigs immersed into 90% CO2 gas for a period of 60s were performed. In study 1, we monitored middle latency auditory evoked potentials (changes in latencies, amplitudes and a depth of anaesthesia index), el
Anaerobic digestion (AD) of minimal nutrient-supplemented wheat straw and digestate liquor recycle was evaluated in semi-continuous processes using a novel BioReactor Simulator developed for easy accurate online normalised-gas measurement. Three scenarios (i) no recycle (NR), (ii) recycle of soluble nutrient (RSN), and (iii) recycle of nutrient and microbes (RNM) were investigated in order to eval
In northern peatlands the thawing of permafrost increasing the active layer depth and changing the hydrology may lead to feedbacks in the climate system through changes in the biogeochemistry of carbon. We are examining this association on the Stordalen peatland complex in subarctic Sweden by analyzing a DEM derived from LiDAR-data and the calculated TWI. The DEM, with a spatial resolution of 1 m,
