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The present study investigates spatial properties of atrial fibrillation (AF) by analyzing VCG loops synthesized from 12-lead ECGs. During intervals with ventricular activity, the atrial signal is extracted using spatiotemporal QRST cancellation, thus making continuous f-wave analysis possible. Spatial properties are characterized through joint analysis of successive fixed-length signal segments,
A high-performance and flexible analog-to-digital converter (ADC), that can be integrated in deep-submicron CMOS technology, is a key building block for reduced size, cost and power consumption of digital communication systems. This dissertation concerns the investigation of particular problems associated with the design of such ADCs. The problem of increased clock jitter sensitivity of low-pass
Background Carrying the cyclin-dependent kinase inhibitor 2A (CDKN2A) germline mutations is associated with a high risk for melanoma. Penetrance of CDKN2A mutations is modified by pigmentation characteristics, nevus phenotypes, and some variants of the melanocortin-1 receptor gene (MC1R), which is known to have a role in the pigmentation process. However, investigation of the associations of both
OBJECTIVES: To determine the ability to correctly identify Cesarean section scars, to estimate the prevalence of defective scars, and to determine the size and location of scar defects by transvaginal ultrasound imaging. METHODS: Two hundred and eighty-seven women underwent transvaginal ultrasound examination 6-9 months after delivery: 108 had undergone one Cesarean section, 43 had had two Cesarea
OBJECTIVE: Imaging follow-up (FU) after endovascular aneurysm repair (EVAR) is usually performed by periodic contrast-enhanced computed tomography (CT) scans. This study aims to evaluate the effectiveness of CT-FU after EVAR. METHODS: In this study, 279 of 304 consecutive patients (261 male, aged 74 years (interquartile range (IQR): 70-79 years) with a median abdominal aortic aneurysm (AAA) diamet
Popular Abstract in Swedish Eftersom mer än 80% av världens samlade energianvändning är beroende av förbränning i någon form är vidare kunskap om förbränningsprocessen viktig. Fortsatt effektivisering av förbränningsprocessen är idag högaktuell för uppbyggnad av framtidens mer miljövänliga energisystem och för utvecklingen utnyttjas omfattande diagnostikarbeten. Inom området anses diagnostik med hThe thesis deals with the further development of pure rotational coherent anti-Stokes Raman spectroscopy (RCARS) for improving the capabilities of gas phase thermometry. The main effort has been to make the technique more robust when employed under a wide range of temperatures and operational conditions. A primary aim has been to investigate the impact of collisional broadening on N2 RCARS thermom
Popular Abstract in Swedish I en alltmer konkurrenskraftig omvärld är det av störst vikt att i ett högkostnadsland som Sverige att innovera och utveckla produkter så effektivt som möjligt. För att uppnå dessa mål finns det klara indikationer på att våra nuvarande produktutvecklings- och konstruktionstillvägagångssätt saknar väsentliga egenskaper för att uppnå önskvärd effektivitet. Den frekvent mIn an industrial context when the product development cycles are shortened and constraints on technical innovations are high, it is very important to provide a very efficient and effective engineering design activity. In the current engineering design literature, most methodologies are by and large based on the so-called systematic engineering design approach. This approach is characterized by an
Many vertebrate animals are known to have multiple sites for photoreception that are not involved in vision. Extraretinal photoreception is indicated to play a crucial role in early development, physiology and behavior, as well as in later biological processes. This thesis encompasses four studies investigating the neuromorphological, neurochemical and molecular basis for extraretinal photosensiti
To predict the service life of a structure, a model where the exposure of a structure is compared to its resistance can be used. Which exposure and resistance parameters that are relevant depend on which materials the structure consist of. This approach, with an exposure and a resistance parameter, is similar to the one used in structural engineering where a load (exposure) is compared to the bear
Spectral hole burning and photon echoes are the techniques for frequency-selective optical memories, which have the potential to increase areal data storage density by a factor 10**7. They also have the capability to perform in-memory data processing. In this thesis, several materials and techniques for optical memories in the frequency- and time domain have been investigated. In the frequency do
Bacillus subtilis can grow on glycerol or glycerol-3-phosphate (G3P) as the sole carbon and energy source. The glpD gene encodes G3P dehydrogenase which is required for the catabolism of glycerol and G3P. In the non-coding leader sequence of glpD there is an inverted repeat followed by a run of AT basepairs which has been shown to function as a Rho-independent terminator (a stem-loop structure fol
OBJECTIVE: To determine whether probiotic prophylaxes reduce the odds of Clostridium difficile infection (CDI) in adults and children. DESIGN: Individual participant data (IPD) meta-analysis of randomized controlled trials (RCTs), adjusting for risk factors. METHODS: We searched 6 databases and 11 grey literature sources from inception to April 2016. We identified 32 RCTs (n=8,713); among them, 18
Although a number of different medium access control (MAC) schemes are adopted for wireless multi-hop networks, time division multiple access (TDMA) approaches based on a periodic frame of time slots are the most common when very high efficiency is needed in terms of use of radio and energy resources. Efficient resource usage is typically based on parallel compatible transmissions from multiple no
Background: To assess the quality of life of people with dementia, measures are required for self-rating by the person with dementia, and for proxy rating by others. The Quality of Life in Alzheimer's Disease scale (QoL-AD) is available in two versions, QoL-AD-SR (self-rating) and QoL-AD-PR (proxy rating). The aim of our study was to analyse the inter-rater agreement between self- and proxy rating
Background: Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukoc
Background: Multimorbidity has already become common in primary care and will be a challenge in the future. Primary care in Sweden participates to a great extent in the care of patients with two severe, chronic conditions: chronic obstructive pulmonary disease (COPD) and heart failure. Both conditions are characterized by high mortality and often coexist. Age, sex, heart failure and other comorbid
The holotype (KUVP 1301) of Styxosaurus snowii—one of the earliest described elasmosaurid plesiosaurians—consists of a well-preserved cranium, mandible and articulated sequence of anterior–mid-series cervical vertebrae found in the lowermost Campanian strata of the Smoky Hill Chalk Member in the Niobrara Formation of Kansas, USA. This particular specimen has proven important for recent phylogenies
Context. Pismis 18 is a moderately populated, intermediate-Age open cluster located within the solar circle at a Galactocentric distance of about seven kpc. Few open clusters have been studied in detail in the inner disc region before the Gaia-ESO Survey. Aims. New data from the Gaia-ESO Survey allowed us to conduct an extended radial velocity membership study as well as spectroscopic metallicity
Background and Purpose- Psychosocial factors can have implications for ischemic stroke risk and recovery. This study investigated the effect of genetically determined risk of depression on these outcomes using the Mendelian randomization (MR) framework. Methods- Genetic instruments for risk of depression were identified in a discovery genome-wide association study of 246 363 cases and 561 190 cont
Anaplastic thyroid cancer (ATC) is a rare and highly aggressive thyroid malignancy, usually resistant to conventional therapeutic strategies. The prognosis of ATC is extremely poor with a median survival rate of 6 months. Current treatment therapy includes surgical resection in combination with external radiotherapy and chemotherapy. The underlying mechanisms involved in ATC tumorigenesis is under
