Filtyp
Introduction There has been a drastic increase in the reported number of people seeking help for gender dysphoria in many countries over the last two decades. Yet, our knowledge of gender dysphoria and related outcomes is restricted due to the lack of high-quality studies employing comprehensive approaches. This longitudinal study aims to enhance our knowledge of gender dysphoria; different aspect
Background: Neuropsychiatric symptoms (NPS) are prevalent in the early clinical stages of Alzheimer’s disease (AD) according to proxy-based instruments. Little is known about which NPS clinicians report and whether their judgment aligns with proxy-based instruments. We used natural language processing (NLP) to classify NPS in electronic health records (EHRs) to estimate the reporting of NPS in sym
Intimate partner violence against women (IPVAW) is a major public health problem in countries around the world, including the Nordic region. Contrary to what would be expected, as the Nordic countries are rated among the most gender equal in the world, survey data suggests that the lifetime prevalence rates of IPVAW in Sweden and neighboring Nordic countries are among the highest in the EU. This p
The causal association of NUDT1 (=MTH1) and OGG1 with hereditary colorectal cancer (CRC) remains unclear. Here, we sought to provide additional evidence for or against the causal contribution of NUDT1 and OGG1 mutations to hereditary CRC and/or polyposis. Mutational screening was performed using pooled DNA amplification and targeted next-generation sequencing in 529 families (441 uncharacterized M
Background Phenylketonuria (PKU) causes irreversible central nervous system damage unless a phenylalanine (PHE) restricted diet with amino acid supplementation is maintained. To prevent growth retardation, a protein/amino acid intake beyond the recommended dietary protein allowance is mandatory. However, data regarding disease and/or diet related changes in body composition are inconclusive and re
BACKGROUND: Increasing life expectancy for people with an intellectual disability (ID) is resulting in more persons with cancer and a greater need for end-of-life (EoL) care. There is a need for knowledge of health care utilisation over the last year of life to plan for resources that support a high quality of care for cancer patients with ID. Therefore, the aims of the study were to compare (1) h
Introduction: In 2011, a homozygous mutation in GOSR2 (c.430G > T; p. Gly144Trp) was reported as a novel cause of Progressive Myoclonus Epilepsy (PME) with early-onset ataxia. Interestingly, the ancestors of patients originate from countries bound to the North Sea, hence the condition was termed North Sea PME (NSPME). Until now, only 20 patients have been reported in literature. Here, we provide a
Introduction: The phase 3 EURIDIS and ADONIS studies evaluated dronedarone for atrial fibrillation (AF)/atrial flutter (AFL) recurrence in patients with nonpermanent AF. Here we assessed whether patient characteristics and/or treatment outcomes in these studies differed based on the need for cardioversion before randomization. Methods: Time to adjudicated first AF/AFL recurrence, symptomatic recur
Background and objective: This publication represents a summary of the updated 2024 European Association of Urology (EAU) guidelines for non–muscle-invasive bladder cancer (NMIBC), TaT1, and carcinoma in situ. The information presented herein is limited to urothelial carcinoma, unless specified otherwise. The aim is to provide practical recommendations on the clinical management of NMIBC with a fo
Several strategies can be used to mitigate flood risks, many of them involves construction of embankments around threatened locations or attempts to spread the flood wave in time and space. In this thesis, the effects of a mitigation strategy called eco-flooding are studied in the catchment of Lake Mälaren. The methodology involves a hypothetical storage in the terrain used as an off-line detentio
In this thesis I will study China's environmental policy process and the challenges of creating and implementing air pollution policies in China. The remarkable economic performance of China in the past 20 years has caused its environment a tremendous distress. The Chinese government have created a quite comprehensive legal framework in order to protect the environment, but the implementation
Free movement of goods is regulated by Article 28 of The EC Treaty. The most important judgments of European Court of Justice (ECJ) in this field are Dassonville, Cassis de Dijon and Keck. The interpretation of Article 28 was very broad in Dassonville and Cassis cases therefore the national rules which were designed for social policy reasons, but not for controlling the trade between Member States
Maternal mortality levels in most low middle income countries is not been the same over the past decades. Among these countries, some of them seem to have an improvement in reducing maternal mortality but the aggregate picture is indicated the regional progress as not that impressive. This is been the case because of the different social and economic policies that each low-middle income countries
This master thesis presents a framework, aimed at assessing fire risk in large automated warehouses. The International Electrotechnical Commission’s (IEC) framework, Risk analysis of technological systems, provides the base, as to the functions of a risk analysis framework and this is subsequently adopted and expanded to better suit the fire risk analysis in high-bay warehouses. The framework pres
Introduction: People with haemophilia (PwH) may experience symptoms of haemophilia-related pain, depression or anxiety, which can negatively impact health-related quality of life. Aim: To obtain the perspective of PwH and treaters from Sweden, Finland and Denmark on the management of haemophilia-related pain, depression and anxiety using cross-sectional survey data from the MIND study (NCT03276130
BACKGROUND: Data in national health care quality registries must be valid and reliable in order to enable open comparisons of results.AIM: To assess the reliability of data on percent consonants correct (PCC) and its associated quality indicator ≥86% correct consonants in the Swedish quality registry for patients born with cleft lip and palate (CLP) registry.METHODS: Six independent speech-languag
