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The Bicoid (Bcd) protein gradient in Drosophila serves as a paradigm for gradient formation in textbooks. To explain the generation of the gradient, the ARTS model, which is based on the observation of a bcd mRNA gradient, proposes that the bcd mRNA, localized at the anterior pole at fertilization, migrates along microtubules (MTs) at the cortex to the posterior to form a bcd mRNA gradient which i
Background Susceptibility to parasite infection affects fitness-related processes, such as mate choice and survival, yet its genetic regulation remains poorly understood. Interleukin-4 (IL4) plays a central role in the humoral immune defence against nematode parasite infections, inducing IgE switch and regulation of worm expulsion from the intestines. The evolutionary and functional significance
Popular Abstract in Swedish Conodonter är en numera utdöd grupp havslevande djur vars systematiska ställning länge varit föremål för debatt. De var i det längsta kända enbart genom sina millimeterstora, kalciumfosfatiska element, vilka vi idag vet satt i djurens munhåla. Sådana conodontelement beskrevs för första gången 1856 av Christian Heinrich Pander, men det skulle dröja närmare 130 år innan dThis thesis deals with conodont biostratigraphy and palaeoecology in the Darriwilian (Middle Ordovician) of Baltoscandia, with focus on limestone strata showing traces of the ~ 470 Ma L-chondrite parent body break-up. The evidence for this cosmic event includes abundant centimeter to decimeter-sized fossil meteorites and elevated levels of sediment-dispersed extraterrestrial L-type chromite found
OBJECTIVE: To estimate the incremental cost-effectiveness of infliximab versus conventional combination treatment over 21 months in patients with methotrexate-refractory early rheumatoid arthritis. METHODS: In this multicentre, two-arm, parallel, randomised, active-controlled, open-label trial, rheumatoid arthritis patients with <1 year symptom duration were recruited from 15 rheumatology clini
Reduced membranous expression of the cytoskeleton-associated protein ezrin has previously been demonstrated to correlate with poor prognosis in urothelial bladder cancer in several independent studies. The present study provides a first description of clinicopathological characteristics of incident urothelial cancers, not only located to the bladder, in the prospective, population-based cohort stu
PURPOSE. To determine the cellular consequences of retinal detachment in retinoschisin knockout (Rs1-KO) mice, a model for retinoschisin in humans. METHODS. Experimental retinal detachments (RDs) were induced in the right eyes of both Rs1-KO and wild-type (wt) control mice. Immunocytochemistry was performed on retinal tissue at 1, 7, or 28 days after RD with antibodies to anti-GFAP, -neurofilament
Stroke causes life long disabilities where few therapeutic options are available. Using electrical and magnetic stimulation of the brain and physical rehabilitation, recovery of brain function can be enhanced even late after stroke. Animal models support this notion, and housing rodents in an enriched environment (EE) several days after experimental stroke stimulates lost brain function by multise
Tubular ceramic membranes with many, small-diameter feed flow channels have the advantage of being less costly per unit membrane area. For this reason, membranes with many small channels are often favored over those with fewer larger channels. We have theoretically studied how the diameter of the feed flow channels influences the frictional pressure drop, the membrane performance (flux and retenti
Background: Published associations between dietary carotenoids and vitamin C and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. Objective: We investigated the association between plasma carotenoids and vitamin C and risk of urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cance
Genetic anomalies on the JNK pathway confer susceptibility to autism spectrum disorders, schizophrenia, and intellectual disability. The mechanism whereby a gain or loss of function in JNK signaling predisposes to these prevalent dendrite disorders, with associated motor dysfunction, remains unclear. Here we find that JNK1 regulates the dendritic field of L2/3 and L5 pyramidal neurons of the mouse
The European Union’s identity as a normative power has long been examined and contested, most famously by Ian Manners' conceptualization in his 2002 work, Normative Power Europe. This study critically reassesses the EU's proposed identity through the lens of its responses to two pivotal crises: the Syrian conflict (2012-2015) and the 2016 EU-Türkiye Refugee Deal. The research interrogates
Current automated haematology systems lack the functionality of avian blood analysis using 10x magnification, which is an important feature as it allows for faster and more cost-effective blood analysis. The problem originates from the difference in red blood cell morphology in avian blood compared to mammalian blood, as the former are nucleated. The project was divided in two objectives, finding
Viktor Orbán’s FIDESZ is often referred to in academia as a right-wing populist political party. However, stemming from Hungary’s history of being dominated by outside powers and having been under communist rule for fifty years, this thesis argues that the nature of FIDESZ’s communication strategy could be heavily influenced by left-wing populist ideals. This thesis seeks to investigate populist a
The purpose of this paper is to gain an understanding into how a neoliberal environmentalist norm-complex can be used to understand the Swedish climate action plans published in 2019 and 2023. This was done through a mixed method approach, where the qualitative stage was allowed to take the most place. The quantitative stage of the analysis showed that the normative element of Green growth and sus
Artificial intelligence (AI) applications change the labour market for human workers. To establish if the applications are determined positive or not, they must be researched in a specified field. One field that is affected by AI applications is the field of economics. In this study, the anxiety towards AI and organisation-based self-esteem (OBSE) in (N = 79) accountants, auditors, and payroll cle
This research builds on the assertion that spirituality can be beneficial to human-wellbeing and in creating nature-connection. Applying that notion within the historical context of Christianity and its ties to the work-ethics of capitalism, the paper presents a case-study of the Threeclover Church, a Protestant Green Church in Denmark’s capital region. The aim is to gain further understanding of
With the projection of a growing amount of waste from photovoltaic (PV) panels in coming years, experts and researchers have highlighted the importance of the circular economy approach to face this challenge. With this approach, risks linked to the composition of PV panels, such as pollution and wastage of valuable materials, can be reduced. Therefore, this thesis aims to provide a systematic view
The present study represents an explorative analysis on women’s bodily expressions from the global south, more specifically women from five Latin American countries: México, Argentina, Paraguay, Chile, and Peru, in the context of mobilizations from the last International Women’s Day. From theoretical perspectives that interconnect epistemological aspects of feminism and resistance, this research p
